The Reparative Function of MMP13 in Tertiary Reactionary Dentinogenesis after Tooth Injury
Henry F. Duncan,
Yoshifumi Kobayashi,
Yukako Yamauchi
et al.
Abstract:MMP13 gene expression increases up to 2000-fold in mineralizing dental pulp cells (DPCs), with research previously demonstrating that global MMP13 deletion resulted in critical alterations in the dentine phenotype, affecting dentine–tubule regularity, the odontoblast palisade, and significantly reducing the dentine volume. Global MMP13-KO and wild-type mice of a range of ages had their molar teeth injured to stimulate reactionary tertiary dentinogenesis. The response was measured qualitatively and quantitative… Show more
“…MMP-9 is responsible for processing the translated protein products into their functional components [ 266 ]. In LPS-simulated pulpitis models, MMP-9 expression was recently found to be significantly upregulated alongside other members of the MMP family, alluding to their involvement in the native tooth injury response [ 267 ]. These findings suggest that modulating MMP-9 expression may present a novel avenue within regenerative solutions.…”
“…MMP-9 is responsible for processing the translated protein products into their functional components [ 266 ]. In LPS-simulated pulpitis models, MMP-9 expression was recently found to be significantly upregulated alongside other members of the MMP family, alluding to their involvement in the native tooth injury response [ 267 ]. These findings suggest that modulating MMP-9 expression may present a novel avenue within regenerative solutions.…”
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