The remyelination effect of DNA framework nucleic acids on demyelinating diseases

Yang, Yuting; Zhu, Jianwei; Ma, Wenjuan; Zhang, Wenqing; Yu, Xianzhong; Chen, Xingyu; Zhu, Junyao; Wang, Kun; Xin, Qin; Lin, Yunfeng

doi:10.1016/j.apmt.2021.101098

Cited by 11 publications

(16 citation statements)

References 49 publications

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“… 9 Our results corroborated with the regulatory effect of tFNAs in cellular biological functions such as migration, proliferation, differentiation, and autophagy and further suggest potent biological functions with practical importance for critically injured terminally differentiated cells such as BMECs. 11 , 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

“… 14 Furthermore, abundant evidence has confirmed that tFNAs successfully alleviate apoptosis of various cell types by restoring normal nuclear morphology, reversing cell cycle abnormalities, and affecting apoptosis mediators. 12 , 15 , 16 …”

Section: Introductionmentioning

confidence: 99%

“…Among these DNA nanomaterials, tetrahedral framework nucleic acids (tFNAs), which can be easily synthesized and edited, have become a major research focus owing to their 3D polyhedral structure and broad biological features 10 . Extensive studies have revealed that tFNAs alone can regulate several cellular processes, such as migration, proliferation, differentiation, and autophagy 11‐13 . Our previous research reported that tFNAs have beneficial effects on normal endothelial cells under physiological conditions, regulating cell viability and promoting angiogenesis 14 .…”

Section: Introductionmentioning

confidence: 99%

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Treatment effect of DNA framework nucleic acids on diffuse microvascular endothelial cell injury after subarachnoid hemorrhage

Chen

Wen

et al. 2022

Cell Proliferation

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Objectives The purpose of this study was to investigate the treatment effect and molecular mechanism of tetrahedral framework nucleic acids (tFNAs), novel self‐assembled nucleic acid nanomaterials, in diffuse BMEC injury after SAH. Materials and Methods tFNAs were synthesized from four ssDNAs. The effects of tFNAs on SAH‐induced diffuse BMEC injury were explored by a cytotoxicity model induced by hemin, a breakdown product of hemoglobin, in vitro and a mouse model of SAH via internal carotid artery puncture in vivo. Cell viability assays, wound healing assays, transwell assays, and tube formation assays were performed to explore cellular function like angiogenesis. Results In vitro cellular function assays demonstrated that tFNAs could alleviate hemin‐induced injury, promote angiogenesis, and inhibit apoptosis in hemin cytotoxicity model. In vivo study using H&E and TEM results jointly indicated that the tFNAs attenuate the damage caused by SAH in situ, showing restored number of BMECs in the endothelium layer and more tight intercellular connectivity. Histological examination of SAH model animals confirmed the results of the in vitro study, as tFNAs exhibited treatment effects against diffuse BMEC injury in the cerebral microvascular bed. Conclusions Our study suggests the potential of tFNAs in ameliorating diffuse injury to BMECs after SAH, which laid theoretical foundation for the further study and use of these nucleic acid nanomaterials for tissue engineering vascularization.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Treatment effect of DNA framework nucleic acids on diffuse microvascular endothelial cell injury after subarachnoid hemorrhage

Chen

Wen

et al. 2022

Cell Proliferation

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“…First, tFNA reduces the level of reactive oxygen species (ROS), thereby reducing the activation of caspases, inhibiting the apoptosis-related signaling pathway, and finally inhibiting apoptosis. Similarly, to explore potential alternative therapies for multiple sclerosis, Yang et al characterized the effects of tFNA on remyelination [126]. They reported that these nucleic acids could accelerate remyelination and enrich myelinated axons by restoring the expression of myelin-related proteins.…”

Section: Tetrahedral Framework Nucleic Acids As Therapeutic Agentsmentioning

confidence: 99%

Therapeutic Applications of Programmable DNA Nanostructures

Aye

Sato

2022

Micromachines

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Deoxyribonucleic acid (DNA) nanotechnology, a frontier in biomedical engineering, is an emerging field that has enabled the engineering of molecular-scale DNA materials with applications in biomedicine such as bioimaging, biodetection, and drug delivery over the past decades. The programmability of DNA nanostructures allows the precise engineering of DNA nanocarriers with controllable shapes, sizes, surface chemistries, and functions to deliver therapeutic and functional payloads to target cells with higher efficiency and enhanced specificity. Programmability and control over design also allow the creation of dynamic devices, such as DNA nanorobots, that can react to external stimuli and execute programmed tasks. This review focuses on the current findings and progress in the field, mainly on the employment of DNA nanostructures such as DNA origami nanorobots, DNA nanotubes, DNA tetrahedra, DNA boxes, and DNA nanoflowers in the biomedical field for therapeutic purposes. We will also discuss the fate of DNA nanostructures in living cells, the major obstacles to overcome, that is, the stability of DNA nanostructures in biomedical applications, and the opportunities for DNA nanostructure-based drug delivery in the future.

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“…Yang showed that, through regulation of mitochondrial apoptotic related proteins such as caspase 3, bcl2 and bax, 250 × 10 -9 M tFNA rescued oligodendroglia progenitor cells from interferon-γ mediated cell death in vitro (Yang et al, 2021). Subsequent in vivo experiments used cuprizone diet for demyelination to establish a mouse model of MS.…”

Section: Multiple Sclerosismentioning

confidence: 99%

Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects

Chen

Liu

et al. 2021

Front. Bioeng. Biotechnol.

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Tetrahedral framework nucleic acid (tFNA), a special DNA nanodevice, is widely applied in diverse biomedical fields. Due to its high programmability, biocompatibility, tissue permeability as well as its capacity for cell proliferation and differentiation, tFNA presents a powerful tool that could overcome potential barriers in the treatment of neurological disorders. This review evaluates recent studies on the use and progress of tFNA-based nanomaterials in neurological disorders.

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The remyelination effect of DNA framework nucleic acids on demyelinating diseases

Cited by 11 publications

References 49 publications

Treatment effect of DNA framework nucleic acids on diffuse microvascular endothelial cell injury after subarachnoid hemorrhage

Treatment effect of DNA framework nucleic acids on diffuse microvascular endothelial cell injury after subarachnoid hemorrhage

Therapeutic Applications of Programmable DNA Nanostructures

Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects

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