The reliability and validity of the Alzheimer's diseases assessment scale cognitive subscale (ADAS-COG) among chinese elderly people in Hong Kong

Chu, Leung‐Wing; Chiu, PW; Tsui, Wilson; Hui, S.L.; Lee, Peter

doi:10.1016/s0197-4580(00)83371-0

Cited by 75 publications

(97 citation statements)

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“…Every subject also received full physical and neurological examination. Standardized cognitive assessment tools including the Chinese versions of Mini-Mental State Examination (MMSE) [16], Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) [17] and Delayed Word Recall Test (DWRT) were performed for all subjects. The DWRT was modified from the Luria Memory Words Test [18] and consisted of 10 Chinese words.…”

Section: Methodsmentioning

confidence: 99%

Increased Alpha 7 Nicotinic Acetylcholine Receptor Protein Levels in Alzheimer’s Disease Patients

Chu

S.K.²,

Lam³

et al. 2005

Dement Geriatr Cogn Disord

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We compared the intact α7 nicotinic acetylcholine receptor (α7nAChR) protein levels in the peripheral blood leukocytes in 15 Alzheimer’s disease (AD) patients and 13 normal elderly control subjects. Demographic data and Mini-Mental State Examination (MMSE) scores were obtained. Western blot analysis for α7nAChR protein levels in peripheral blood leukocytes was performed. There were no significant differences in sex and age between the AD and control groups. The mean MMSE score of the AD subjects was significantly lower than that of the normal control subjects (15.4 ± 5.5 vs. 28.5 ± 1.9 respectively; p < 0.001). The median value of normalized α7nAChR protein levels (optical density, arbitrary unit) of the AD group was significantly higher than that of the normal control group (0.6923 vs. 0.4803 respectively; p = 0.045, Mann-Whitney U test). The normalized α7nAChR protein levels showed a significant inverse correlation with the MMSE scores (Spearman rho = –0.45; p = 0.016; n = 28). Receiver Operating Characteristic curve analyses showed that the area under curve was 0.72 (95% CI 0.52– 0.87). If the cut-off of the α7nAChR protein level was >0.312, the sensitivity, specificity, positive predictive value and negative predictive value would be 80, 39, 60 and 63%, respectively. These findings showed that the α7nAChR protein levels would be a potentially useful diagnostic marker for AD.

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Section: Methodsmentioning

confidence: 99%

Increased Alpha 7 Nicotinic Acetylcholine Receptor Protein Levels in Alzheimer’s Disease Patients

Chu

S.K.²,

Lam³

et al. 2005

Dement Geriatr Cogn Disord

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“…These subjects underwent full physical and neurological examination, standardized cognitive assessments, and a 1-hour battery of neuropsychological tests, as reported in our previous studies (Chu et al 2009). Standardized cognitive assessment tools including the Chinese versions of the MMSE (Chiu et al 1994), Alzheimer's Disease Assessment Scale-cognitive subscale (Chu et al 2000), and Delayed 10-Word Recall Test were used. For verbal memory, the Logical Memory subtest from the Wechsler Memory Scale-third edition and the Free and Cued Selective Reminding Test were administered (Petersen et al 1992;Weschler 1997).…”

Section: Subjectsmentioning

confidence: 99%

Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T

Chiu

Mak

Yau

et al. 2013

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Magnetic resonance spectroscopy (MRS) can explore aging at a molecular level. In this study, we investigated the relationships between regional concentrations of metabolites (such as choline, creatine, myo-inositol, and N-acetyl-aspartate) and normal aging in 30 cognitively normal subjects (15 women and 15 men, age range 22-82, mean=49.9±18.3 years) using quantitative proton magnetic resonance spectroscopy. All MR scans were performed using a 3 T scanner. Point resolved spectroscopy was used as the volume selection method for the region-of-interest and the excitation method for water suppression. Single voxel spectroscopy with short echo time of 39 ms and repetition time of 2,000 ms was employed.Single voxels were placed in the limbic regions, i.e., anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and left and right hippocampi. Cerebrospinal fluid normalization and T1 and T2 correction factors were implemented in the calculation of absolute metabolite concentrations. A standardized T1W 3D volumetric fast field echo and axial T2-weighted fast spin-echo images were also acquired. Our results showed significant positive correlation of choline (r=0.545, p=0.002), creatine (r=0.571, p=0.001), and N-acetyl-aspartate (r= 0.674, p<0.001) in the ACC; choline (r=0.614, p< 0.001), creatine (r=0.670, p<0.001), and N-acetyl-aspartate (r=0.528, p=0.003) in the PCC; and NAA (r=0.409, p=0.025) in the left hippocampus, with age. No AGE (2014) significant gender effect on metabolite concentrations was found. In aging, increases in choline and creatine might suggest glial proliferation, and an increase in Nacetyl-aspartate might indicate neuronal hypertrophy. Such findings highlight the metabolic changes of ACC and PCC with age, which could be compensatory to an increased energy demand coupled with a lower cerebral blood flow.

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“…The total possible score is 70, with increasing scores indicating a greater severity of impairment. A locally validated Chinese version for the screening of subjects with AD has been developed [17] .…”

Section: Semantic Fluency In Questionable Dementiamentioning

confidence: 99%

Reduced Semantic Fluency as an Additional Screening Tool for Subjects with Questionable Dementia

Lam

Lui

et al. 2006

Dement Geriatr Cogn Disord

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Background: Subjective memory complaints in subjects with mild cognitive impairment may represent a genuine decline in episodic memory. This paper evaluates the neuropsychological correlates of the semantic fluency test in subjects with questionable dementia (QD). Methods: A total of 331 Chinese subjects (118 normal controls, NC, 150 with QD and 63 with mild Alzheimer’s disease, AD) were assessed with the Category Verbal Fluency Test (CVFT), the AD Assessment Scale – cognitive subscale (ADAS-Cog), and digit and verbal span tests. CVFT performance was evaluated in each Clinical Dementia Rating (CDR) group. The total number of exemplars, the subcategory and the category size generated were evaluated. Neuropsychological correlates of CVFT scores were computed. Results: Significant differences in CVFT performance were found between the different CDR groups. The subjects with QD had intermediate scores compared to the NC and AD subjects (1-way ANOVA, p < 0.001, post-hoc Bonferroni comparisons). In NC the CVFT scores were significantly associated with ADAS-Cog total, and immediate and delayed recall scores (partial correlations controlled for age and education, p < 0.005). In the QD group the CVFT scores were correlated with ADAS-Cog total, and immediate recall and object naming scores (partial correlation controlled for age and education, p < 0.005). Regression analysis revealed that age and delayed recall were significant predictors of CVFT performance in NCs. In the QD group, age, ADAS-Cog immediate recall and object naming scores predicted the CVFT performance. Conclusions: The CVFT was impaired in the subjects with QD. Apart from episodic memory, semantic memory deficits also occur early in AD. The different cognitive predictors of CVFT scores in the NC and QD groups suggest that the test is associated with specific psychological functions at different stages of cognitive impairment.

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The reliability and validity of the Alzheimer's diseases assessment scale cognitive subscale (ADAS-COG) among chinese elderly people in Hong Kong

Cited by 75 publications

References 0 publications

Increased Alpha 7 Nicotinic Acetylcholine Receptor Protein Levels in Alzheimer’s Disease Patients

Increased Alpha 7 Nicotinic Acetylcholine Receptor Protein Levels in Alzheimer’s Disease Patients

Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T

Reduced Semantic Fluency as an Additional Screening Tool for Subjects with Questionable Dementia

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