The relevance of complement to virus biology

Blue, Clare; Spiller, O. Brad; Blackbourn, David J.

doi:10.1016/j.virol.2003.11.029

Cited by 93 publications

(105 citation statements)

References 81 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…Complement is a critical component of the innate immune response and contributes to defenses against multiple viral pathogens, including poxviruses (5,40). In response to the antiviral effects of complement, viruses have developed strategies to evade complement activation (4,9,27,35).…”

mentioning

confidence: 99%

“…Complement activation by the classical, lectin, and alternative pathways results in production of fragments with distinct antiviral properties (5,58,59). These include the proinflammatory peptides C3a and C5a, as well as C3b and C4b, which can mediate direct virus neutralization by opsonizing viral particles.…”

mentioning

confidence: 99%

“…These include the proinflammatory peptides C3a and C5a, as well as C3b and C4b, which can mediate direct virus neutralization by opsonizing viral particles. Production of C3b also leads to downstream activation of C5 and formation of the membrane attack complex, which lyses infected cells and enveloped viral particles (5). Complement activation can also contribute to defense against viral infection by enhancing adaptive antibody (Ab) and T cell responses.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection

Girgis

DeHaven

Xiao

et al. 2011

J Virol

View full text Add to dashboard Cite

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection

Girgis

DeHaven

Xiao

et al. 2011

J Virol

View full text Add to dashboard Cite

“…It is possible that replication of HSV in the lower respiratory tract may have subtle effects on lung function and gas exchange without there necessarily being overt cytopathic effects visible by histochemistry. HSV encodes a range of proteins which modify the immune response including modification of the cytokine response [Blue et al, 2004]. Such subtle modifications may impair recovery from the primary cause of lung dysfunction in ways to become evident only in ways such as the increase in mortality at lower admission APACHE II scores shown in this study.…”

Section: Discussionmentioning

confidence: 81%

“…It has been recognised that altered cytokine levels are associated with acute respiratory distress syndrome [Bhatia and Moochhala, 2004]. Also, many herpes viruses interfere with the complement cascade [Blue et al, 2004].…”

mentioning

confidence: 99%

Detection of herpes viruses in respiratory secretions of patients undergoing artificial ventilation

Smith

Conroy

Pollock

et al. 2010

Journal of Medical Virology

View full text Add to dashboard Cite

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 AbstractThe significance of detection of herpes viruses in respiratory secretions of critically ill patients is controversial. The study aim was to determine the prevalence of herpes virus DNA in respiratory secretions in patients on artificial ventilation. Respiratory secretions taken thrice weekly from 174 patients in a tertiary centre Intensive Therapy Unit (ITU) were tested for Herpes Simplex Virus (HSV) by nested PCR. Samples from 61 patients in ITU for 4 days or more were also tested for Epstein Barr Virus (EBV) and Cytomegalovirus (CMV) using real-time PCR.HSV positivity increased with ITU stay with 18.6% admission samples positive, 32.5 % day 2-5 samples, and 65.9% day 6-39 samples. Being HSV positive on admission did not influence mortality (9/27, 33.3% v 38/118, 32.2%) however, subsequently, mortality of those negative but becoming positive was higher than in those remaining negative (10/35, 29% v 5/24 21%). At least one sample was EBV positive in 61% and CMV positive in 19% of patients tested. Of 63 patients tested for all three viruses, 4 were positive for three viruses, 23 patients for two viruses, 24 for one virus and 12 were negative for all the above viruses.Detection of HSV, EBV and CMV is common in ITU patients. Becoming HSV positive while in ITU may increase mortality. Word count 204

show abstract

Expression of Concern: The pathophysiological and immunological background of the monkeypox virus infection: An update

Mukherjee

Wanjari

Kannampuzha

et al. 2022

Journal of Medical Virology

View full text Add to dashboard Cite

In addition to the COVID‐19 waves, the globe is facing global monkeypox (MPX) outbreak. MPX is an uncommon zoonotic infection characterized by symptoms similar to smallpox. It is caused by the monkeypox virus (MPXV), a double‐stranded DNA virus that belongs to the genus Orthopoxvirus (OPXV). MPXV, which causes human disease, has been confined to Africa for many years, with only a few isolated cases in other areas. Outside of Africa, the continuing MPXV outbreak in multiple countries in 2022 is the greatest in recorded history. The current outbreak, with over 10 000 confirmed cases in over 50 countries between May and July 2022, demonstrates that MPXV may travel rapidly among humans and pose a danger to human health worldwide. The rapid spread of such outbreaks in recent times has elevated MPX to the status of a rising zoonotic disease with significant epidemic potential. While the MPXV is not as deadly or contagious as the variola virus that causes smallpox, it poses a threat because it could evolve into a more potent human pathogen. This review assesses the potential threat to the human population and provides a brief overview of what is currently known about this reemerging virus. By analyzing the biological effects of MPXV on human health, its shifting epidemiological footprint, and currently available therapeutic options, this review has presented the most recent insights into the biology of the virus. This study also clarifies the key potential causes that could be to blame for the present MPX outbreak and draw attention to major research questions and promising new avenues for combating the current MPX epidemic.

show abstract

The relevance of complement to virus biology

Cited by 93 publications

References 81 publications

The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection

The Vaccinia Virus Complement Control Protein Modulates Adaptive Immune Responses during Infection

Detection of herpes viruses in respiratory secretions of patients undergoing artificial ventilation

Expression of Concern: The pathophysiological and immunological background of the monkeypox virus infection: An update

Contact Info

Product

Resources

About