The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients

Evans, Jovier D.; Heaton, Robert K.; Paulsen, Jane S.; Palmer, Barton W.; Patterson, Thomas L.; Jeste, Dilip V.

doi:10.1016/s0006-3223(02)01476-2

Cited by 143 publications

(102 citation statements)

References 34 publications

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“…Cognition has been established as a predictor of realworld community functioning in schizophrenia (Green et al, 2000;Evans et al, 2003) and 69% of our sample of psychotic cannabis users reported a social use of cannabis, a similar proportion as in controls. Thus, our findings are compatible with the view that, among psychotic patients, the better premorbid cognition of the group who had smoked cannabis is likely to have facilitated their use of the drug in a normal recreational way, sharing it with their friends.…”

Section: Why Is Lifetime Cannabis Use Associated With Better Premorbimentioning

confidence: 66%

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Ferraro

Russo

O’Connor

et al. 2013

Schizophrenia Research

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a b s t r a c t a r t i c l e i n f oBackground: A number of studies have reported that patients with psychosis who use cannabis have better cognitive performance than those who do not. This is surprising as cannabis can impair cognition in healthy subjects. An obvious question is whether the better current performance of psychotic patients who have used cannabis is a reflection of their having a higher premorbid IQ than those psychotic patients who haven't used cannabis. Aim: In a sample of patients at their first episode of psychosis, we tested the hypothesis that patients who smoked cannabis would have a higher premorbid IQ than patients who did not. Methodology: 279 participants (119 patients and 160 healthy controls) were assessed in order to obtain current and premorbid IQ measures and detailed information on cannabis use. We examined the association between cannabis use and both premorbid and current IQ in patients and controls. Results: Patients who had ever smoked cannabis had significantly higher current (p b .001) and premorbid IQ (p = .004) compared to patients who had never used cannabis. This difference was not found among controls. Conclusions: These findings suggest that the better cognitive performance of patients with their first episode of psychosis who have used cannabis compared with those who haven't is due to the better premorbid IQ of the former.

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Section: Why Is Lifetime Cannabis Use Associated With Better Premorbimentioning

confidence: 66%

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Ferraro

Russo

O’Connor

et al. 2013

Schizophrenia Research

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“…Patients in this study were relatively high functioning and had good personal care skills, suggesting that they are able to rate functional ability areas that were relatively more intact. Previous research (Evans et al, 2003) found that this ability area was not related to cognitive impairments as well, probably due to ceiling effects on measures of personal care. Further, external standards for personal care may be more easily discernable than, for instance, social skills to people with schizophrenia, leading to more accurate appraisals.…”

Section: Discussionmentioning

confidence: 81%

Self-assessment of functional status in schizophrenia

Bowie

Twamley

Anderson

et al. 2007

Journal of Psychiatric Research

245

172

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With new treatments targeting features of schizophrenia associated with functional disability, there is a need to evaluate the validity of ratings of everyday outcomes. It is unknown whether patients can validly self-report on aspects of their functional status, which would be a potentially economical method for obtaining outcome data. In this study, 67 older schizophrenia outpatients provided self-ratings of everyday real-world functioning using the specific levels of functioning scale (SLOF). They were also administered assessments of neuropsychological performance, performance-based measures of functional capacity and social skills, clinical symptoms, and quality of life. Case managers, unaware of other ratings, also generated SLOF ratings. Based on discrepancy scores, participants were categorized as accurate raters (n = 24), underestimators (n = 16), or overestimators (n = 27) of their functional status as compared to case managers' ratings. Patients' self-rated functional status was correlated with their subjective quality of life, but remarkably unassociated with case manager ratings of functional status or their own performance on functional capacity or social skills measures. Case manager ratings, however, were highly correlated with performance on functional capacity and social skills measures. Patients who underestimated their real world performance had better cognitive skills and greater self-rated depression than those who overestimated. Accurate raters demonstrated greater social skills than both overestimators and underestimators, while overestimators were most cognitively and functionally impaired. Accurate ratings of everyday outcomes in schizophrenia may require systematic observation of real world outcomes or performance-based measures, as self-reports were inconsistent with objective information.

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“…Cognitive abilities are associated with functional capacity and community outcomes (Evans et al, 2003;Twamley et al, 2002;Patterson et al, 2001;Green and Nuechterlein, 1999;Green, 1996;Green et al, 2000), and may also affect life satisfaction. Poorer cognitive performance and self-reported functional status (e.g., unmarried, lower social functioning, smaller social support network) are correlated with lower subjective QOL (Corrigan and Buican, 1995;Norman et al, 2000;Lehman et al, 1983a).…”

Section: Predictors Of Subjective Qolmentioning

confidence: 99%

Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

225

139

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Objective-Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually defined as participation in activities and relationships). We examined separately the clinical, functional, and cognitive predictors of subjective and objective QOL in outpatients with schizophrenia. We hypothesized that better subjective QOL would be associated with less severe negative and depressive symptoms, better objective QOL, and greater everyday functioning capacity, and that better objective QOL would be associated with less severe negative and depressive symptoms, better cognitive performance, and greater functional capacity.Method-Participants included 88 outpatients with schizophrenia or schizoaffective disorder who completed a comprehensive series of assessments, including measures of positive, negative, and depressive symptoms; performance-based functional skills; a neuropsychological battery; and an interview measure of subjective and objective QOL.Results-In the context of multiple predictor variables, more severe depressive symptoms and better neuropsychological functioning were independent predictors of worse subjective QOL. More severe negative symptoms predicted worse objective QOL. Functional capacity variables were not associated with subjective or objective QOL.Conclusion-Treatments to improve QOL in schizophrenia should focus on negative symptoms and depressive symptoms.

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The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients

Cited by 143 publications

References 34 publications

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Cannabis users have higher premorbid IQ than other patients with first onset psychosis

Self-assessment of functional status in schizophrenia

Subjective and objective quality of life in schizophrenia

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