The relationship of increased amniotic fluid volume to perinatal outcome

Varma, T.R.; Bateman, Samantha; Patel, R.H.; Chamberlain, Geoffrey; Pillai, Unnikrishnan

doi:10.1016/0020-7292(88)90108-7

Cited by 20 publications

(15 citation statements)

References 12 publications

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“…Varma et al 13 in a study of 135 pregnancies complicated with hydramnios between 32 and 36 weeks noted that pregnancies complicated by hydramnios had a higher incidence of preterm delivery, fetal distress, low Apgar score, macrosomia, fetal anomolies, perinatal mortality and admission to NICU. In the present study, we compared the pregnancy and perinatal outcome of 201 twin pregnancies with hydramnios diagnosed at less than 30 weeks' gestation, to 13,111 twin controls.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Hydramnios on Pregnancy Outcome in Twin Gestations

Orhan

Kurzel

Istwan³

et al. 2004

J Perinatol

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OBJECTIVE:To compare pregnancy outcome in twin pregnancies with and without hydramnios. STUDY DESIGN:A database of women receiving outpatient preterm labor surveillance services was studied for the period 1988 to 2002. Included were women with twin gestations under 30 weeks' gestation at start of outpatient services. We compared pregnancy outcomes for twin gestations with hydramnios (n ¼ 201) to twin gestations that had normal amniotic fluid volume (n ¼ 13,111). RESULTS:Obstetrical and perinatal outcomes in twin pregnancies were adversely affected by the presence of hydramnios. Delivery was shifted to earlier gestations in women with hydramnios (32.8 vs 35.1 weeks, p<0.001), especially under 32 weeks (38.3 vs 12.7%). Perinatal loss was notable in women with hydramnios: stillbirths (12.7 vs 1.1%, p<0.001) and neonatal mortality (7.5 vs 1.1%, p<0.001). CONCLUSIONS:Hydramnios in twin gestations negatively impacts gestational age at delivery. The incidence of perinatal mortality is significantly increased in the presence of hydramnios.

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Section: Discussionmentioning

confidence: 99%

The Impact of Hydramnios on Pregnancy Outcome in Twin Gestations

Orhan

Kurzel

Istwan³

et al. 2004

J Perinatol

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“…Numerous studies have linked polyhydramnios with preterm delivery [5,19,20]. Since our control group was matched for gestational age, it could not be used to evaluate the prematurity rate in the study group.…”

Section: Discussionmentioning

confidence: 99%

“…Since most reports use neonatal or pathologic data to determine their congenital malformation rate [5,6], differing levels of sonographic technical expertise cannot explain the wide range in the prevalence of congenital anomalies with polyhydramnios. Queenan et al [7] used a dye dilution technique to quantify amniotic fluid volume in normal pregnancies.…”

Section: Introductionmentioning

confidence: 99%

The Severity of Polyhydramnios, Estimated Fetal Weight and Preterm Delivery Are Independent Risk Factors for the Presenceof Congenital Malformation s

Lazebnik

Many

1999

Gynecol Obstet Invest

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Objective: To evaluate maternal and fetal factors associated with congenital malformations in patients with polyhydramnios. Study Design: The study group consisted of 275 singleton pregnancies with an amniotic fluid index (AFI) >25.0 cm. An equal number of controls were matched for maternal age, gravidity, parity and gestational age. The proportion of cases and controls with malformations was compared. Polyhydramnios cases were categorized into three groups by severity: mild (AFI 25–30 cm), moderate (AFI: 30.1–35.0 cm) and severe (AFI >35.1 cm). Among cases, logistic regression analysis was utilized to estimate the risk for fetal congenital malformations in relation to severity of polyhydramnios, estimated fetal weight, maternal diabetic status and gestational age at delivery. Results: Congenital malformations were detected in 40 of 275 cases (14.5%) with polyhydramnios and in 9 cases (3.3%) of the control group (p < 0.01). The relative risks of congenital malformations increased with the severity of polyhydramnios: 3.2 (95% CI 1.5–6.8), 5.7 (95% CI 2.4–13.3) and 13.1 (95% CI 5.8–29.5) for mild, moderate and severe polyhydramnios, respectively. Congenital malformations among polyhydramnios cases were present in 54.5% of small-for-gestational age fetuses, in contrast to 12.7% for average-for-gestational age fetuses and 10.8% for large-for-gestational age fetuses (p < 0.001). Maternal diabetic status did not significantly affect the fetal anomaly rate once polyhydramnios was detected. Premature newborns in the polyhydramnios group had a higher malformation rate (24%) than did term newborns (11.3%) (p < 0.02). In the study group, multiple logistic analysis confirmed the significance of severe polyhydramnios, small-for-gestational age status and preterm delivery as independent contributors to the malformation risk. Conclusions: Polyhydramnios (AFI >35 cm), small-for-gestational age fetus and preterm delivery are independent risk factors for congenital malformations.

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“…[3][4][5][6] The associa.ti. on between the severity of polyhydramnios and fetal size has not been specifically investigated.…”

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confidence: 99%

Severity of polyhydramnios does not affect the prevalence of large-for-gestational-age newborn infants.

Lazebnik

Hill

Guzick

et al. 1996

Journal of Ultrasound in Medicine

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The purpose of this study was to evaluate the relationship between the severity of polyhydramnios with or without maternal diabetes and the prevalence of large‐for‐gestational‐age newborn infants. A case control design was used. The study group consisted of 275 singleton pregnancies with an amniotic fluid index > or = 25.0 cm. An equal number of controls was matched for maternal age, gravidity, parity, and gestational age. Polyhydramnios was categorized into three groups by severity: mild (amniotic fluid index 25 to 30 cm.); moderate (amniotic fluid index, 30.1 to 35.0 cm); and severe (amniotic fluid index > or = 35.1 cm). Among our study group, 72.7%, 19.7%, and 7.6% of cases had mild, moderate, and severe polyhydramnios, respectively. Patients with polyhydramnios had a significantly higher prevalence of large‐for‐gestational‐age neonates (27%) than did controls (10%) (P < 0.001). No correlation was seen between the severity of polyhydramnios and neonatal delivery weight. The prevalence of gestational and class > or = B diabetes mellitus was significantly higher among patients with polyhydramnios (17.7%) than among controls (7%) (P < 0.003). Once polyhydramnios was diagnosed sonographically, however, maternal diabetic status did not affect the prevalence of large‐for‐gestational‐age newborn infants. We conclude that the prevalence of large‐for‐gestational‐age neonates is 2.7 times greater when polyhydramnios is present than when the amniotic fluid volume is normal. Neither the severity of polyhydramnios nor the presence of maternal diabetes mellitus strengthens the relationship between polyhydramnios and large‐for‐gestational‐age newborn infants.

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The relationship of increased amniotic fluid volume to perinatal outcome

Cited by 20 publications

References 12 publications

The Impact of Hydramnios on Pregnancy Outcome in Twin Gestations

The Impact of Hydramnios on Pregnancy Outcome in Twin Gestations

The Severity of Polyhydramnios, Estimated Fetal Weight and Preterm Delivery Are Independent Risk Factors for the Presenceof Congenital Malformation s

Severity of polyhydramnios does not affect the prevalence of large-for-gestational-age newborn infants.

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