The Relationship of Drug Therapy to Aplastic Anemia in Pakistan: A Hospital-Based Case Control Study

Syed, Muhammad Asif; Rahman, Aneela; Syed, Muhammad Nadeem Shah; Masood, Naveed

doi:10.2147/tcrm.s325742

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…AA may arise as a result of pharmacological drugs that have been found in a number of investigations. Avoiding suspicious medicines will reduce the prevalence of AA (8). To counteract drug-induced AA, it is imperative to remove the suspected substance as soon as possible.…”

Section: Discussionmentioning

confidence: 99%

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Oral Manifestations of Aplastic Anemia: A Case Report

Hedayati Panah,

Shahsavand Baghdadi,

Fatholahi

2023

Avicenna J Dent Res

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Aplastic anemia (AA) is a rare disease characterized by pancytopenia, susceptibility to infection, and difficulty maintaining hemostasis. Drugs are considered to be one of the most important risk factors associated with AA. Various studies have identified the pharmaceutical agents that may contribute to the development of AA. It is common for patients with severe periodontal disease and AA to experience spontaneous bleeding during brushing in terms of thrombocytopenia, which may further exacerbate dental problems. AA patients require comprehensive periodontal treatment that necessitates collaboration with a hematologist.

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Section: Discussionmentioning

confidence: 99%

“…The two primary therapeutic options are immunosuppressive therapy and allogeneic stem cell transplantation. The medications cyclosporine and antithymocyte globulin may also be used to treat AA (8,10). Among all antibiotics, cephalosporins are the safest.…”

Section: Discussionmentioning

confidence: 99%

Oral Manifestations of Aplastic Anemia: A Case Report

Hedayati Panah,

Shahsavand Baghdadi,

Fatholahi

2023

Avicenna J Dent Res

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“…Low-income countries still widely use chloramphenicol because it is cost effective and readily available. Bone marrow toxicity is the most serious and generally fatal adverse effect associated with chloramphenicol treatment [16].…”

Section: Chloramphenicolmentioning

confidence: 99%

"Exploring Novel Compounds from Soil Streptomyces: An Intervention for The Challenge of Drug Resistance and A Potential Avenue for New Drug Discovery"

Onisile

2022

BJSTR

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The increasing development of antimicrobial resistance among pathogenic microorganisms and the challenges it poses to the health sector requires an urgent need for investigation of natural products for novel bioactive compounds. New drugs are needed to alleviate the menace of antimicrobial resistance which is a global concern coupled with emerging strains of disease-causing organisms. Due to this resistance, clinicians and medical practitioners have shifted their focus to older antimicrobial agents such as tetracyclines and aminoglycosides isolated from Streptomyces spp. as a result of chemical modification to the existing antibiotic scaffold. The World Health Organisation recently updated the list of multidrug-resistant bacteria to which there is an urgent need for new antibiotics. Streptomyces produces large numbers of clinically important antibiotics and is readily available in natural sources such as soil and plants. This review explores old and effectively used antibiotics produced from Streptomyces and the potential of newly discovered antimicrobial agents from this source.

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“…Direct marrow damage most commonly occurs from chemotherapy and radiation. However, it can be less commonly caused by a variety of agents, including benzene-containing compounds as well as thiazide diuretics, anticonvulsant medications such as carbamazepine, antithyroid agents such as methimazole, chloramphenicol and trimethoprim/sulfamethoxazole 3 4. Here, we present a unique case of a female patient in her 70s who presented with aplastic anaemia following antibiotic treatment with ciprofloxacin and nitrofurantoin.…”

Section: Introductionmentioning

confidence: 97%

Aplastic anaemia following antibiotic use for urinary tract infection

Sharma,

Suresh,

Pirruccello

et al. 2024

BMJ Case Rep

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Aplastic anaemia is often associated with recent viral illnesses to include EBV and parvovirus along with certain medications such as anticonvulsants and sulfa containing antibiotics. We describe a case report of a female patient in her 70s who presented with pancytopenia after being treated with nitrofurantoin and ciprofloxacin for suspected urinary tract infection. She underwent an extensive workup to rule out alternative aetiologies of her pancytopenia to include a broad viral, autoimmune and malignancy evaluation which were unrevealing. Given her recent exposure to ciprofloxacin and nitrofurantoin and marrow recovery following removal of these agents, it was presumed that antibiotic exposure was the underlying cause of her aplastic anaemia.

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The Relationship of Drug Therapy to Aplastic Anemia in Pakistan: A Hospital-Based Case Control Study

Cited by 6 publications

References 27 publications

Oral Manifestations of Aplastic Anemia: A Case Report

Oral Manifestations of Aplastic Anemia: A Case Report

"Exploring Novel Compounds from Soil Streptomyces: An Intervention for The Challenge of Drug Resistance and A Potential Avenue for New Drug Discovery"

Aplastic anaemia following antibiotic use for urinary tract infection

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