The relationship of dermatomyositis and polymyositis to internal malignancy

Callen, Jeffrey P.

doi:10.1001/archderm.116.3.295

Cited by 66 publications

(52 citation statements)

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“…Dermatomyositis commonly has a subacute onset and is progressive over months to years (Callen et al 1980). The rapid onset and evolution of the disease in this patient is relatively unusual and, despite his response to corticosteroid therapy, permanent impairment of muscle power subsequently ensued.…”

Section: Discussionmentioning

confidence: 77%

“…The reported prevalence of malignancy in adults with dermatomyositis has varied from 15% to 50% (Barnes 1976, Callen et al 1980, Callen 1982), but using the more stringent criteria of Bohan & Peter (1975) the true figure is probably between 20% and 30% (Callen 1982). Dermatomyositis associated with oesophageal carcinoma appears to have been recorded only rarely in large reviews (Barnes 1976) and a small number of individual cases have been reported but none in English (Lombardo & Ferrari 1968, Gautier et al 1969, Francois et at.…”

Section: Discussionmentioning

confidence: 99%

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Acute Dermatomyositis Associated with Squamous Carcinoma of the Oesophagus

Karp

1985

J R Soc Med

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The case of a patient with dermatomyositis and squamous carcinoma of the oesophagus is reported. No previous individual case report in English of this association has been traced. The patient responded to high-dose steroid therapy. The importance of differentiating dysphagia due to malignancy from that due to dermatomyositis is discussed.Case report A 63-year-old advertising consultant presented in July 1983 with a three-month history of epigastric discomfort after meals, abdominal bloating, intermittent regurgitation of food and the loss of one stone (6.3 kg) in weight. He had a past medical history of hypertension and had suffered a transient ischaemic attack 7 months previously when he was noted to have early clubbing. He was taking atenolol and aspirin, was a pipe smoker and consumed moderate quantities of alcohol. Physical examination now revealed marked clubbing and he was also noted to have palmar erythema. Routine blood investigations were normal. An upper gastrointestinal endoscopy revealed an extensive, ulcerating polypoidal carcinoma of the oesophagus extending 25-35 cm from the incisor teeth. The endoscope could not be passed distally. Biopsies showed this to be a poorly differentiated squamous cell carcinoma.Following a small haematemesis he received a split course of radiotherapy, with an initial 3000 cGy being administered in 8 fractions over two weeks and the same dose again six weeks later. He tolerated this very well, with considerable improvement in his swallowing and weight gain. Three weeks after completion of his radiotherapy he suddenly developed pain and weakness in his proximal limb muscles, a generalized itchy desquamating skin rash and lethargy. These symptoms rapidly progressed and he was admitted to hospital three weeks later.Examination revealed marked finger clubbing and a florid magenta-coloured scaly eruption on his face including both upper eyelids, the nape of his neck, elbows, forearms, dorsal hands, interphalangeal joints and dorsal proximal phalanges. There was nail-fold telangiectasia and slight scarring of the fingers, particularly both little fingers.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Acute Dermatomyositis Associated with Squamous Carcinoma of the Oesophagus

Karp

1985

J R Soc Med

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“…The frequency of malignancy among adult patients with PM/DM varies from 7% to 24% [11,12,19]. This association is more maintained in patients with DM.…”

Section: Discussionmentioning

confidence: 98%

Pattern of Adult Onset of Polymyositis and Dermatomyositis and Association with Malignancy

et al. 1993

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“…It is very rare to present as paraneoplastic syndrome, like dermatomyositis (DM) as in our case. [6]. In Asia the most common malignancy associated with DM are nasopharyngeal cancer and breast cancer in male and female respectively, whereas lung and ovarian cancer are the main malignancies in the Western patients [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

Breast cancer associated with paraneoplastic dermatomyositis (DM); case report

Anter¹,

Alfotih²

2017

Hematol Med Oncol

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SummaryBreast cancer is the most common cancer in women. Dermatomyositis (DM) is an uncommon idiopathic inflammatory myopathy manifested by classic skin findings and proximal muscle weakness. However, DM may also manifest as a paraneoplastic syndrome of an underlying malignancy. Here, we report a case of a patient who presented with breast cancer and DM symptoms. The patient's rash and muscle weakness progressed during the first cycle of neoadjuvant chemotherapy, while she was already started on medical treatment of these symptoms with oral prednisone. Her cutaneous and musculoskeletal improved dramatically following the treatment of her breast cancer with surgery. Our case report describes the rapid progression and regression of her symptoms emphasizing the benefit of early diagnosis and treatment of DM as well as the underlying breast cancer.

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The relationship of dermatomyositis and polymyositis to internal malignancy

Cited by 66 publications

References 0 publications

Acute Dermatomyositis Associated with Squamous Carcinoma of the Oesophagus

Acute Dermatomyositis Associated with Squamous Carcinoma of the Oesophagus

Pattern of Adult Onset of Polymyositis and Dermatomyositis and Association with Malignancy

Breast cancer associated with paraneoplastic dermatomyositis (DM); case report

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