The Relationship of Birth Size and Postnatal Growth with Cellular Senescence in Adults: Data from the New Delhi Birth Cohort

Tarik, Mohamad; Sinha, Sukesh Narayan; Sachdev, H. P. S.; Tandon, Nikhil; Roy, Ambuj; Bhargava, Santosh K.

doi:10.1007/s12098-022-04174-4

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In human adults with a mean age of 43.04 years, birth weight was inversely associated with p21 gene expression but not with p16 expression, markers of cellular senescence. What is interesting, the expression of p21 but not p16, was positively correlated with BMI gain at 29 years and current BMI [93]. In men, lower birth weight predicted advanced biological aging based on epigenetic clocks [94].…”

Section: Discussionmentioning

confidence: 94%

Birth size and the pace of aging in men

Żelaźniewicz

Nowak-Kornicka

Pawłowski

2023

Preprint

View full text Add to dashboard Cite

Previous studies showed that intrauterine growth restrictions, resulting in smaller body size at birth, are associated with altered development and the risk of age-related diseases in adult life. Thus, prenatal development may predict aging trajectories in humans. The study aimed to verify if body size at birth is related to biological age in adult men. The study sample consisted of 159 healthy, non-smoking men with a mean age of 35.24 (SD = 3.44) years. Birth weight and length were taken from medical records. The ponderal index at birth was calculated. Biological age was evaluated based on serum levels of s-Klotho, hsCRP, DHEA/S, and oxidative stress markers. Pregnancy age at birth, lifestyle, weight, cortisol, and testosterone levels were controlled. The results showed no relationship between birth size and s-Klotho, DHEA/S level, inflammation, or oxidative stress. Also, men born as small-for-gestational-age (N = 49) and men born as appropriate-for-gestational-age (N = 110) did not differ in terms of biological age markers levels. The results were similar when controlled for pregnancy week at birth, chronological age, BMI, testosterone, or cortisol level. The results suggest that there is no relationship between intrauterine growth and biomarkers of aging in men aged 30–45 years from the affluent population.

show abstract

Section: Discussionmentioning

confidence: 94%

Birth size and the pace of aging in men

Żelaźniewicz

Nowak-Kornicka

Pawłowski

2023

Preprint

View full text Add to dashboard Cite

show abstract

Birth size and the serum level of biological age markers in men

Żelaźniewicz,

Nowak-Kornicka,

Pawłowski

2023

Sci Rep

View full text Add to dashboard Cite

Previous studies showed that intrauterine growth restrictions, resulting in smaller body size at birth, are associated with altered development and the risk of age-related diseases in adult life. Thus, prenatal development may predict aging trajectories in humans. The study aimed to verify if body size at birth is related to biological age in adult men. The study sample consisted of 159 healthy, non-smoking men with a mean age of 35.24 (SD 3.44) years. Birth weight and length were taken from medical records. The ponderal index at birth was calculated. Biological age was evaluated based on serum levels of s-Klotho, hsCRP, DHEA/S, and oxidative stress markers. Pregnancy age at birth, lifestyle, weight, cortisol, and testosterone levels were controlled. The results showed no relationship between birth size and s-Klotho, DHEA/S level, inflammation, or oxidative stress. Also, men born as small-for-gestational-age (N = 49) and men born as appropriate-for-gestational-age (N = 110) did not differ in terms of biological age markers levels. The results were similar when controlled for pregnancy week at birth, chronological age, BMI, testosterone, or cortisol level. The results suggest that there is no relationship between intrauterine growth and biomarkers of aging in men aged 30–45 years from the affluent population.

show abstract

The Relationship of Birth Size and Postnatal Growth with Cellular Senescence in Adults: Data from the New Delhi Birth Cohort

Cited by 2 publications

References 22 publications

Birth size and the pace of aging in men

Birth size and the pace of aging in men

Birth size and the serum level of biological age markers in men

Contact Info

Product

Resources

About