The Relationship between Type II Diabetes and Alzheimer’s Disease

Abstract

Alzheimer’s disease (AD) currently stands as a prominent focal point in contemporary research, ranking among the top ten causes of death worldwide. At the same time, diabetes has also secured its position as the third most prevalent ailment in developed countries. While more and more people are paying attention to these two diseases, it is worth noting that certain researchers have posited that type 2 diabetes (T2D) has a substantial influence on the development of AD. However, there is still a lack of unified explanation of underlying mechanics framework and extent of its influence remains elusive. This review will explore the risk factors, shared mechanisms, and convergent signaling pathways that contribute to AD and T2D, with an emphasis on the participation of mitochondrial dysfunction, abnormal glucose metabolism, inflammation, oxidative stress and insulin resistance. The relationship between AD and T2D is still unknown. Nonetheless, understanding the common mechanisms and signaling pathways of this harmful interchange between AD and T2D may offer new avenues for identifying potential therapeutic targets and devising effective treatment strategies.