The relationship between the metabolic syndrome and energy-utilization deficit in the pathogenesis of obesity-induced osteoarthritis

Rojas-Rodriguez, Jorge; Escobar-Linares, Luis E.; Garcı́a-Carrasco, Mario; Escárcega, Ricardo O.; Fuentes-Alexandro, Salvador; Zamora-Ustaran, Alfonso

doi:10.1016/j.mehy.2007.01.075

Cited by 43 publications

(25 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sowers et al suggested that leptin and adiponectin levels influenced OA development 29 . Another hypothesis suggests that in obese subjects, metabolic changes in the striated muscles induced by interactions between insulin resistance and systemic inflammation may lead to fatigue and muscle weakness, influencing the balance between damage and repair mechanisms and ultimately leading to OA 42,43 . Inflammatory factors are suggested to be associated with both obesity and KOA 44,45 .…”

Section: Discussionmentioning

confidence: 99%

Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study

Yoshimura

Muraki

Oka

et al. 2012

Osteoarthritis and Cartilage

293

206

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study

Yoshimura

Muraki

Oka

et al. 2012

Osteoarthritis and Cartilage

293

206

View full text Add to dashboard Cite

show abstract

“…This may constitute a pathogenic mechanism by which conditions such as DM could promote degenerative changes that facilitate the progression of OA [24]. Rojas-Rodríguez et al reported that pathogenesis of obesity-induced OA may be explained by the metabolic changes in the striated muscle induced by the interaction of insulin resistance and systemic inflammation in obese individuals [25]. It is also known that pro-inflammatory molecules are among critical mediators of the disturbed processes implicated in OA pathophysiology [26].…”

Section: Discussionmentioning

confidence: 99%

Association of Hand or Knee Osteoarthritis With Diabetes Mellitus in a Population of Hispanics From Puerto Rico

Nieves-Plaza¹,

Castro-Santana²,

Font³

et al. 2013

JCR: Journal of Clinical Rheumatology

View full text Add to dashboard Cite

Background Although a higher prevalence of osteoarthritis (OA) has been reported among diabetes mellitus (DM) patients, inconsistencies and limitations of observational studies have precluded a conclusive association. Objective To evaluate the association of hand or knee OA with DM in a population of Hispanics from Puerto Rico. Methods A cross-sectional study was performed in 202 subjects (100 adult DM patients as per the National Diabetes Data Group Classification, and 102 non-diabetic subjects). OA of hand and knee was ascertained using the American College of Rheumatology classification criteria. Sociodemographic characteristics, health-related behaviors, comorbidities, pharmacotherapy and DM clinical manifestations were determined. Multivariable logistic regression was used to evaluate the association of DM with hand or knee OA, and to evaluate factors associated with hand or knee OA among DM patients. Results The mean (standard deviation, SD) age for DM patients was 51.6 (13.1) years; 64.0% were females. The mean (SD) DM duration was 11.0 (10.4) years. The prevalence of OA in patients with DM and non-diabetics subjects was 49.0% and 26.5%, respectively (p<0.01). In the multivariable analysis, patients with DM had 2.18 the odds of having OA when compared to non-diabetic subjects (95% CI: 1.12–4.24). In a sub-analysis among DM patients, female patients were more likely to have hand or knee OA (OR [95% CI]: 5.06 [1.66–15.66]), whereas patients who did not use insulin alone for DM therapy were more likely to have OA (OR [95% CI]: 4.44 [1.22–16.12]). Conclusion In this population of Hispanics from Puerto Rico, DM patients were more likely to have OA of hands or knees than non-diabetic subjects. This association was retained in multivariable models accounting for established risk factors for OA. Among DM patients, females were at greater risk for OA, whereas the use of insulin was negatively associated.

show abstract

“…Adipose tissue is known as a source of proinflammatory and anti-inflammatory adipokines, which have been suggested to play a role in OA pathogenesis 4–7. Furthermore, hyperglycaemia and diabetes have been related to OA,8–12 possibly via insulin-like growth factor I resistance of chondrocytes,13 via changes in striated muscles due to insulin resistance,14 or via formation of advanced glycation end products 15 16. The association of OA with measures of atherosclerosis suggests another systemic link with OA,17 18 possibly via systemic inflammation or pathology of subchondral bone vasculature 19…”

Section: Introductionmentioning

confidence: 99%

The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study

et al. 2014

View full text Add to dashboard Cite

show abstract

The relationship between the metabolic syndrome and energy-utilization deficit in the pathogenesis of obesity-induced osteoarthritis

Cited by 43 publications

References 41 publications

Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study

Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study

Association of Hand or Knee Osteoarthritis With Diabetes Mellitus in a Population of Hispanics From Puerto Rico

The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study

Contact Info

Product

Resources

About