The relationship between subclinical cardiovascular disease and lipocalin-2 levels in women with PCOS

Gencer, Meryem; Gazı, Emıne; Hacıvelioğlu, Servet; Binnetoğlu, Emine; Barutçu, Ahmet; Türkön, Hakan; Temız, Ahmet; Altun, Burak; Vural, Ahmet; Cevızcı, Sibel; Kumcular, Tuncer; Çoşar, Emine

doi:10.1016/j.ejogrb.2014.07.032

Cited by 16 publications

(17 citation statements)

References 33 publications

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“…We found high lipocalin-2 levels in women with PCOS and did not find any significant association between lipocalin-2 and cardiovascular marker hs-CRP or HOMA-IR. There were no significant differences in circulating lipocalin-2 levels in overweight women versus lean women in both PCOS and healthy controls [10]. In our study, lipocalin-2 levels and body fat percentages were higher in PCOS than in BMI-matched controls -still lipocalin-2 was not associated with body fat percentage.…”

Section: Prace Oryginalnecontrasting

confidence: 70%

“…Gencer et al found that lipocalin-2 concentrations were significantly lower in women with PCOS. Moreover, lipocalin-2 was not associated with cardiovascular risk indicators as defined by echocardiographic examination [10]. Diamanti-Kandarakis et al demonstrated that circulating lipocalin-2 levels were significantly lower in women with PCOS and were not associated with obesity, insulin resistance, and estradiol concentrations [3].…”

Section: Prace Oryginalnementioning

confidence: 99%

“…Although women with PCOS have numerous risk factors that can cause cardiovascular disease, it was reported that the incidence of cardiovascular events was not elevated in PCOS [29]. Therefore, the results of Diamanti-Kandarakis highlighted that lipocalin-2 is related to cardiovascular events rather than atherosclerotic heart disease; lipocalin-2 may have a protective role in PCOS [3,10].…”

Section: Prace Oryginalnementioning

confidence: 99%

“…Lipocalin-2 binds to bacterial iron-laden siderophores to inhibit bacterial growth [9]. Several studies have been published reporting either increased, decreased, or unchanged lipocalin levels in both PCOS and other insulin resistance-related disorders, but the potential mechanism underlying these inconsistent results has not been wholly elucidated [3,[6][7][8][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Związek między stężeniami lipokaliny-2 i testosteronu wolnego w zespole policystycznych jajników

Yılmaz¹,

Temür²,

Çalan

et al. 2017

Endokrynologia Polska

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Introduction: Lipocalin-2 is an adipokine that is mainly produced from adipocytes and macrophages. Data related to PCOS and other obesity-associated disorders have shown divergent results. Here, we studied lipocalin-2 concentrations in women with PCOS and in healthy women, and investigated the potential contributors underlying lipocalin association with PCOS. Material and methods: Forty-four women with PCOS and 47 age-and BMI-matched healthy women were enrolled. Fasting serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP), and free testosterone levels were measured. The body fat percentage was measured by bioelectrical impedance. Results: Lipocalin-2 concentrations were significantly higher in the PCOS group than in the control group (55.74 ± 17.54 ng/mL vs. 36.46 ± 19.62 ng/mL, p = 0.011). There was a correlation between lipocalin-2 levels and free testosterone. In a multiple regression model, the body fat percentage, HOMA-IR, and hs-CRP were not associated with lipocalin-2. However, only free testosterone was associated with lipocalin-2. A "lipocalin-2 = 11.214 + (1.943 × free-testosterone)" equation was obtained. Conclusions: Serum lipocalin-2 levels were higher in women with PCOS, and only free testosterone was associated with lipocalin-2. Lipocalin-2 levels and their influencing factors have discrepant results in both PCOS and other obesity-or insulin resistance-related metabolic disorders. Thus, the potential role of lipocalin-2 in PCOS should be clarified. (Endokrynol Pol 2017; 68 (1): 7-12)

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Section: Prace Oryginalnecontrasting

confidence: 70%

Section: Prace Oryginalnementioning

confidence: 99%

Section: Prace Oryginalnementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Związek między stężeniami lipokaliny-2 i testosteronu wolnego w zespole policystycznych jajników

Yılmaz¹,

Temür²,

Çalan

et al. 2017

Endokrynologia Polska

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“…cIMT is a good and cheap indicator for subclinical atherosclerosis (23). A strong correlation has also been found between NGAL and cIMT (28,29). Because of increased cytokine expression and infl ammation in combination with HP-infection it is known that cardiac insuffi ciency and coronary heart disease develop (30,31).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori can be related to carotid intima-media thickness, epicardial adipose tissue thickness and serum neutrophil gelatinase-associated lipocalin (NGAL) levels

Karadağ¹,

Sehitoglu²,

Cüre³

et al. 2018

BLL

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Comprehensive Meta-Analysis of Functional and Structural Markers of Subclinical Atherosclerosis in Women with Polycystic Ovary Syndrome

Sun

Ding

et al. 2022

Angiology

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The relationship between polycystic ovary syndrome (PCOS) and subclinical atherosclerosis remains unclear. We performed a comprehensive systematic review and meta-analysis to evaluate the effect of PCOS on functional and structural markers of subclinical atherosclerosis as measured by carotid intima-media thickness (cIMT), flow-mediated vasodilation (FMD), nitroglycerin-mediated vasodilation (NMD), pulse wave velocity (PWV), and coronary artery calcium (CAC). Standard mean differences (SMDs) or odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. Ninety-six articles involving 5550 PCOS patients and 5974 controls were included. Compared with controls, PCOS patients showed significantly thicker cIMT (SMD (95% CI) = .587 (.398, .776), P < .001), lower FMD (SMD (95% CI) = −.649 (−.946, −.353), P < .001) and NMD (SMD (95% CI) = −.502 (−.686, −.317), P < .001), as well as higher PWV (SMD (95% CI) = .382 (.019, .746), P = .039), and increased CAC incidence (OR (95% CI) = 2.204 (1.687, 2.879), P < .001). When analyzing subgroups by age and body mass index (BMI), results were still significant ( P < .05) except for PWV in the BMI subgroup. There was no significant result on sensitivity analysis, and Begg’ test or Egger’s test. PCOS contributes to subclinical atherosclerosis, resulting in functional and structural changes in cIMT, FMD and NMD, PWV, and CAC incidence.

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The relationship between subclinical cardiovascular disease and lipocalin-2 levels in women with PCOS

Cited by 16 publications

References 33 publications

Związek między stężeniami lipokaliny-2 i testosteronu wolnego w zespole policystycznych jajników

Związek między stężeniami lipokaliny-2 i testosteronu wolnego w zespole policystycznych jajników

Helicobacter pylori can be related to carotid intima-media thickness, epicardial adipose tissue thickness and serum neutrophil gelatinase-associated lipocalin (NGAL) levels

Comprehensive Meta-Analysis of Functional and Structural Markers of Subclinical Atherosclerosis in Women with Polycystic Ovary Syndrome

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