The Relationship between Sleep Apnea Syndrome and Hypothyroidism

Lin, Ching-Chi; Tsan, Kun-Wu; Chen, Pei-Jan

doi:10.1378/chest.102.6.1663

Cited by 124 publications

(81 citation statements)

References 14 publications

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“…2 The distribution of thyroid disorder frequencies in control group Fig. 3 The distribution of thyroid disorder frequencies in obstructive sleep apnea patients symptoms such as fatigue, decreased libido, depressed mood, impaired concentration, obesity and edema [3,5,[22][23][24]. Recently it was suggested that these symptoms might also be related to serum antibody levels of patients with thyroiditis, even if the patient was euthyroid [25].…”

Section: Discussionmentioning

confidence: 99%

The association between severity of obstructive sleep apnea and prevalence of Hashimoto’s thyroiditis

et al. 2012

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Section: Discussionmentioning

confidence: 99%

The association between severity of obstructive sleep apnea and prevalence of Hashimoto’s thyroiditis

et al. 2012

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“…11 Nevertheless, replacement therapy of cortisol and/or thyroxine deficiencies should reverse all of the clinical manifestations, including sleepiness, unless additional causes for sleepiness, such as sleep apnea, are present. [12][13][14][15] Thus, well-treated patients would not be expected to display sleepiness, and if they do, other causes should be sought.…”

mentioning

confidence: 99%

Severe Hypersomnolence After Pituitary/Hypothalamic Surgery in Adolescents: Clinical Characteristics and Potential Mechanisms

Snow¹,

Gozal

Malhotra

et al. 2002

Pediatrics

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ABSTRACT. Objectives. After resection of hypothalamic/pituitary tumors, children are at risk for development of hormonal deficiencies, obesity, and hypersomnolence. However, the prevalence and pathophysiology of these complications are unclear. The purpose of this study was to assess the prevalence and severity of hypersomnolence in children after resection of pituitary tumors and to study the potential factors that contribute to this sleepiness if present. We further hypothesized that decrements in orexin levels may contribute to the sleepiness.Methods. Six children who underwent hypothalamic/ pituitary surgery were identified. Five of these patients and 5 matched control subjects underwent overnight polysomnography followed by a multiple sleep latency test. Children who had a primary sleep disorder (eg, obstructive sleep apnea) underwent treatment and were restudied subsequently (n ‫؍‬ 2). Blood levels of pituitary hormones were measured. Blood and cerebrospinal fluid (CSF) were drawn from 4 patients and 3 control subjects to measure orexin levels.Results. Endocrine control was appropriate in all children. Although patients had longer sleep duration but similar sleep efficiency than control subjects, relatively severe daytime somnolence was present (mean sleep latency: 10.3 ؎ 5.3 minutes vs 26.2 ؎ 1.1 minute in control subjects). Sleepiness did not correlate with body mass index or age. Furthermore, serum and CSF orexin levels did not differ between patients and control subjects.Conclusions. Severe daytime sleepiness is frequent among children who undergo pituitary/hypothalamic surgery and does not seem to result from inappropriate cortisol or thyroxine replacement, disturbed nocturnal sleep, or low levels of orexin in the serum or CSF. We therefore speculate that other, unidentified neurohormonal mechanisms may mediate the excessive sleepiness of these patients. Pediatrics 2002;110(6). URL: http:// www.pediatrics.org/cgi/content/full/110/6/e74; sleep, excessive daytime sleepiness, adolescents, orexin (hypocretin), brain tumors, craniopharyngioma.

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“…33 However, the prevalence of hypothyroidism was only 3% in 65 consecutive patients diagnosed to have OSA. 34 CPAP therapy may be started in patients with severe hypothyroidism and severe OSA and in patients with an urgent need to treat OSA in combination with thyroid hormone replacement therapy.…”

Section: Pharmacological Therapy:-mentioning

confidence: 99%