The relationship between red cell distribution width and cardiac autonomic function in heart failure

Yamada, Shuichi; Yoshihisa, Akiomi; Kaneshiro, Takashi; Amami, Kazuaki; Hijioka, Naoko; Oikawa, Masayoshi; Takeishi, Yasuchika

doi:10.1002/joa3.12442

Cited by 10 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It seems hence rational that this simple parameter may reflect the adverse prognosis in many clinical conditions. There are several studies indicating the prognostic performance of advanced RDW level in coronary artery disease ( 11 , 12 ), heart failure ( 13 , 14 ), atrial fibrillation ( 15 , 16 ), and new-onset stroke ( 17 , 18 ). Existing reports on the relationship between RDW and CKD are comparatively sparse.…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Distribution Width Is Associated With Adverse Kidney Outcomes in Patients With Chronic Kidney Disease

et al. 2022

View full text Add to dashboard Cite

BackgroundChronic kidney disease (CKD) is a global public health issue. Red blood cell distribution width (RDW) is a recently recognized potential inflammatory marker, which mirrors the variability in erythrocyte volume. Studies indicate that elevated RDW is associated with increased risk of mortality in CKD patients, while evidence regarding the impact of RDW on kidney outcome is limited.MethodsAltogether 523 patients with CKD stage 1–4 from a single center were enrolled. We identified the cutoff point for RDW level using maximally selected log-rank statistics. The time-averaged estimated glomerular filtration rate (eGFR) slope was determined using linear mixed effects models. Rapid CKD progression was defined by an eGFR decline >5 ml/min/1.73 m2/year. The composite endpoints were defined as doubling of serum creatinine, a 30% decline in initial eGFR or incidence of eGFR < 15 ml/min/1.73 m2, whichever occurred first. Multivariable logistic regression or Cox proportional hazards regression was performed, as appropriate.ResultsDuring a median follow-up of 26 [interquartile range (IQR): 12, 36] months, 65 (12.43%) patients suffered a rapid CKD progression and 172 (32.89%) composite kidney events occurred at a rate of 32.3/100 patient-years in the high RDW group, compared with 14.7/100 patient-years of the remainder. The annual eGFR change was clearly steeper in high RDW group {−3.48 [95% confidence interval (CI): −4.84, −2.12] ml/min/1.73 m2/year vs. −1.86 [95% CI: −2.27, −1.45] ml/min/1.73 m2/year among those with RDW of >14.5% and ≤14.5%, respectively, P for between-group difference <0.05}. So was the risk of rapid renal function loss (odds ratio = 6.79, 95% CI: 3.08–14.97) and composite kidney outcomes (hazards ratio = 1.51, 95% CI: 1.02–2.23). The significant association remained consistent in the sensitivity analysis.ConclusionIncreased RDW value is independently associated with accelerated CKD deterioration. Findings of this study suggest RDW be a potential indicator for risk of CKD progression.

show abstract

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Distribution Width Is Associated With Adverse Kidney Outcomes in Patients With Chronic Kidney Disease

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Recently, more studies have shown that the RDW value can be useful in predicting the poor prognosis in patients with cardiovascular diseases including atrial brillation [15], heart failure [16], and cardiogenic shock, etc. [17].…”

Section: Discussionmentioning

confidence: 99%

Association of red cell distribution width with mortality in cardiac arrest patients: a retrospective analysis based on the MIMIC-IV database

Zhong

Jin

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background There is a scarcity of studies that covers the relationship between the red cell distribution width (RDW) and the prognosis of cardiac arrest (CA) patients. Moreover, the prognostic value of the changes in RDW during intensive care unit (ICU) hospitalization for CA patients is not investigated. This study focuses on the correlation between RDW measures at ICU admission and RDW changes during ICU hospitalization and the prognosis of CA patients. Methods A retrospective cohort study is used to collect clinical characteristics of CA patients (>18years) that are on their first admission to ICU with RDW data measured from the Medical Information Mart for Intensive Care-IV database. The primary outcomes are 30- and 90-day all-cause mortality. A multivariate Cox regression model is applied to test whether the RDW represents an independent risk factor that affects the all-cause mortality of these patients. Meanwhile, the dose-response relationship between the RDW and the mortality is described by the restricted cubic spine (RCS). Results A total of 1138 adult CA patients are included in this study. Compared to the survivor group, non-survivors show higher level of RDW. The Kaplan-Meier survival curve indicates that the cumulative survival rate of CA patients at 30 and 90 days decreases gradually as the RDW on ICU admission increases (log-rank test, χ 1 2 =46.460,χ 2 2 =47.210, both p-values<0.001), and rising RDW during ICU hospitalization (ΔRDW>=0.4%) is associated with decreased the 30 and 90 days cumulative survival rates (χ 1 2 =23.700,χ 2 2 =25.390, both p-values<0.001). The multivariate Cox regression analysis shows that increasing RDW at ICU admission (≥13.89%) and rising RDW during ICU hospitalization (ΔRDW>=0.4%) are independent risk factors for death at 30- and 90-day on CA patients. RCS illustrates that there is a non-linear relationship between the RDW on ICU admission and the increased risk of mortality of CA patients at 30 (χ 1 2 =11.990, p-value=0.007) and 90 days (χ 2 2 =12.340, p-value=0.006). Conclusions Elevated RDW levels on ICU admission and rising RDW during ICU hospitalization are powerful predictors of all-cause mortality for CA patients at 30 and 90 days, and they can be used as potential clinical biomarkers to predict the bad prognosis of these patients.

show abstract

“…12 In literature reviews, it is recommended to be cautious in terms of nutritional deficiencies, renal failure, stress, increased neurohormonal activity, cardiac events and heart failure in case of high RDW. [22][23][24] It is not certain that the above-mentioned problems are caused by high RDW alone, it suggests that high RDW may indicate important problems.…”

Section: Itemsmentioning

confidence: 99%

Investigation of red cell distribution width as a prognostic criterion in severe burns

Akkoç

Bülbüloğlu

2021

International Wound Journal

View full text Add to dashboard Cite

This study was conducted to examine red cell distribution width (RDW) as a prognostic criterion in severe burns. The study is a descriptive correlational study and was carried out retrospectively. Patients with high RDW and low albumin values among severe burn injuries in the burn unit of a university hospital constituted half of the sample. Severe burns with RDW within normal range and a prognostic criterion for which albumin level normal and closest to normal accounted for the other half. RDW and albumin values were compared with the clinical results of patients with severe burns. IBM SPSS (Statistical Package for the Social Sciences) Statistics 25 was used for data analysis. Of the burn patients, 38.33% were between the age of 65-80, 51.67% were men, and 92.5% had third-degree burns. The mean albumin level of the patients was 2.39 ± 0.34 g/dL, and the mean RDW level was 18.47 ± 6.15%. The length of the stay in the intensive care unit was 13.45 ± 7.83 days, and the duration of central venous catheter use was 23.41 ± 8.25 days. High RDW and low albumin values were found to be associated with death, length of stay in the intensive care unit, and more blood transfusion. High RDW and hypoalbuminemia significantly affect the clinical results of severe burns. Both parameters are effective in determining the clinical course of burn patients, the length of hospital stay, presence of catheters and medication treatment protocol.

show abstract

The relationship between red cell distribution width and cardiac autonomic function in heart failure

Cited by 10 publications

References 29 publications

Red Blood Cell Distribution Width Is Associated With Adverse Kidney Outcomes in Patients With Chronic Kidney Disease

Red Blood Cell Distribution Width Is Associated With Adverse Kidney Outcomes in Patients With Chronic Kidney Disease

Association of red cell distribution width with mortality in cardiac arrest patients: a retrospective analysis based on the MIMIC-IV database

Investigation of red cell distribution width as a prognostic criterion in severe burns

Contact Info

Product

Resources

About