The Relationship Between Pulse Pressure, the Estimated Glomerular Filtration Rate, and Urine Microalbumin/Creatinine Ratio in Korean Adults

Abstract

Background/Aims: Pulse pressure (PP) is a predictor of adverse outcomes in patients on haemodialysis. Thus, the present study was conducted to assess the relationship between PP, estimated glomerular filtration rate (eGFR), and urine microalbumin/creatinine ratio (uACR) in Korean adults. Methods: Data of 9,409 adults (4,206 men and 5,203 women) aged ≥ 20 years from the Sixth Korean National Health and Nutrition Examination Survey (2013–2014) were analyzed. Results: A multivariate analysis revealed that systolic blood pressure (SBP) (β = -0.170, 95% confidence interval [CI], -0.216 to -0.159), diastolic blood pressure (DBP) (β = 0.088, 95% CI 0.108–0.200; p < 0.001), and PP (β = -0.134, 95% CI -0.215 to -0.157) were significant factors determining eGFR. In contrast, SBP (β = 0.152, 95% CI, 0.985–1.456; p < 0.001), DBP (β = -0.062, 95% CI -1.141 to -0.442; p < 0.001), and PP (β = 0.118, 95% CI 0.965–1.436; p < 0.001) were the significant factors determining uACR. The odds ratios (ORs) of a high PP (PP ≥ 60 mmHg) with a normal group [eGFR ≥ 60 ml/min/1.73 m² and uACR < 30 mg/g] as a reference were significant for decreased eGFR [eGFR < 60 ml/min/1.73 m², 1.484 (95% CI, 1.003–2.196)], elevated uACR [uACR ≥ 30 mg/g, 2.592 (95% CI, 2.085–3.223)], and decreased eGFR plus elevated uACR [eGFR < 60 ml/min/1.73 m² and uACR ≥ 30 mg/g, 3.889 (95% CI, 2.519–6.004)]. Conclusion: Enhanced PP was associated with a decreased eGFR and an increase in uACR in Korean adults. In addition, the PP increased greatly when a decrease in eGFR and an increase in uACR appeared simultaneously.

Development and Validation of Prediction Models for Hypertensive Nephropathy, the PANDORA Study

“…The early pathological changes of hypertension-related renal damage entail remodeling of small renal arteries that may be a response to a persistent increase in BP with elevated PP (52). Indeed, PP is an established marker of hypertensive target-organ damage whose correlation with damage was further confirmed in a Korean adult study (53) and the LOD-RISK study (54). Our model predicts that the ideal management of hypertension may require not only lowering SBP and DBP but also maintaining PP in a lower range to protect the kidneys from HN.…”

Gender Influence on XOR Activities and Related Pathologies: A Narrative Review

“…The difference between systolic and diastolic blood pressure is called the pulse pressure and is a predictor of arterial stiffness, which is a risk factor for CVD [38] and CKD [39]. The analysis of data from the seventh Korean National Health and Nutrition Examination Survey, including 2800 men and 3510 women, indicates that both the systolic and pulse pressures are positively associated with the level of uricemia in women, but not in men [40].…”

Relationship between Albuminuria and Uric Acid to High-Density Lipoprotein Cholesterol Ratio in Korean Adults

“…알부민뇨(albuminuria)는 신장에서 알부민이 여과되지 않 고 소변으로 나타나는 현상으로 요 미세알부민/요 크레아티닌 비율(urine microalbumin to urine creatinine ratio, uACR) 로 측정한다 [1]. 알부민뇨는 심장 및 신장의 혈관 내피 손상에 대 한 초기 징후를 나타내기 때문에 [2] 심혈관질환 및 만성신장질 환의 예측인자라고 알려져 있다 [3].…”