The relationship between postnatal skin maturation and electrical skin impedance

Mize, M. M.

doi:10.1001/archderm.125.5.647

Cited by 9 publications

(9 citation statements)

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“…we found to our surprise that the skin surface hydration of newborns is much lower than that of adults. This phenomenon was suggested by electrical skin impedance measurements (low-frequency method) that were highest in newborn infants (3). This method, however, refiects water contained in the living tissues ofthe skin, which is also lower in newborns (3).…”

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confidence: 98%

Dry Skin of Newborn Infants: Functional Analysis of the Stratum Corneum

Saijo

Tagami

1991

Pediatric Dermatology

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Our clinical observations disclosed that most newborn infants showed scaling on at least some parts of the body. To clarify the mechanism for such xerosis, we performed measurements of high-frequency conductance (Gx), which assesses the skin surface hydration and evaporative water loss from the skin. The skin of newborns showed surprisingly lower Gx values and evaporative water loss than those of adults or 1- to 6-month-old infants in a warm environment. These findings may be explained partly by low eccrine activity, which has been reported as characteristic of newborn skin. However, defective stratum corneum function, such as reduced water-holding capacity as demonstrated by the in vivo water sorption-desorption test, also seems to be responsible for the development of dry skin in newborns.

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confidence: 98%

Dry Skin of Newborn Infants: Functional Analysis of the Stratum Corneum

Saijo

Tagami

1991

Pediatric Dermatology

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“…It is worthy to note that the use of these two indices in model design has been revealed in previous research, though relating neither to clavus nor to verruca. Impedance magnitude is found to be one of the important indices in analyzing electrical impedance spectra [6], [10], [12], [18]–[20], [26], [27]. While, phase angle is in association with the studies concerning cancers, chronic obstructive pulmonary disease, HIV, hospital mortality of geriatric patients, and skin condition test [10], [12], [26], [28], [29].…”

Section: Discussionmentioning

confidence: 99%

“…Thickness parameter, although showing capabilities in distinguishing between clavus and verruca, is observed to pose problems in impedance analysis, due partly to the difficulties in specifying measured locations, and due partly to its variations caused by biological factors and environmental conditions [10], [27]. In addition to this, the thickness of the sample, unlike all the other indices acquired by LCR-meter, is measured manually.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Differential Diagnosis of Clavus and Verruca by a Predictive Model Generated from Electrical Impedance

et al. 2014

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BackgroundSimilar clinical appearances prevent accurate diagnosis of two common skin diseases, clavus and verruca. In this study, electrical impedance is employed as a novel tool to generate a predictive model for differentiating these two diseases.Materials and MethodsWe used 29 clavus and 28 verruca lesions. To obtain impedance parameters, a LCR-meter system was applied to measure capacitance (C), resistance (Re), impedance magnitude (Z), and phase angle (θ). These values were combined with lesion thickness (d) to characterize the tissue specimens. The results from clavus and verruca were then fitted to a univariate logistic regression model with the generalized estimating equations (GEE) method. In model generation, log ZSD and θSD were formulated as predictors by fitting a multiple logistic regression model with the same GEE method. The potential nonlinear effects of covariates were detected by fitting generalized additive models (GAM). Moreover, the model was validated by the goodness-of-fit (GOF) assessments.ResultsSignificant mean differences of the index d, Re, Z, and θ are found between clavus and verruca (p<0.001). A final predictive model is established with Z and θ indices. The model fits the observed data quite well. In GOF evaluation, the area under the receiver operating characteristics (ROC) curve is 0.875 (>0.7), the adjusted generalized R 2 is 0.512 (>0.3), and the p value of the Hosmer-Lemeshow GOF test is 0.350 (>0.05).ConclusionsThis technique promises to provide an approved model for differential diagnosis of clavus and verruca. It could provide a rapid, relatively low-cost, safe and non-invasive screening tool in clinic use.

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“…Likewise Rutter et al stated that in term babies the water loss from the palms and soles measured in terms of the water vapor pressure gradient increased from birth up to the age of 4 weeks, and explained this increase by the onset of emotional sweating (16). The skin impedance, which is the "resistance" to an alternating current, has been shown to drop during the 1st postnatal months, and this is explained by increased skin hydration, again the product of greater functional maturity of the eccrine sweat glands (17). Emery states that the highest level of impedance is present at term, and then drops over the next 4 months (18).…”

Section: Discussionmentioning

confidence: 99%

Skin Conductance Changes During the First Year of Life in Full-Term Infants

Hernes

Mørkrid²,

Fremming

et al. 2002

Pediatr Res

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Skin conductance changes (SCC) reflect the activity in the sympathetic postganglionic cholinergic fibers, which innervate the sweat glands located in the palm of the hand and the sole of the foot. The purpose of this study was to measure the changes in the number of waves per second, the wave amplitude, and the mean skin conductance level during the 1st year of life. During SCC elicited by an auditory stimulus we measured the percentage of infants that responded, the amplitude, latency and recovery times, and any habituation pattern. Thirty-nine full-born, healthy infants were investigated during their 1st and 3rd days of life, at 3 and 10 wk of life, and at 6 and 12 mo of life. The mean skin conductance level (p < 0.001), the number of waves with an amplitude threshold higher than 0.5 and 1.0 micro siemens (p < 0.001), and the amplitude of the waves (p < 0.001) all increased during the first 10 wk of life. The percentage that responded to stimuli increased from 8% to 50%, and the amplitude of the response increased during the first 10 wk of life (p < 0.001). The level of arousal influenced the mean skin conductance level, the number of waves per second, and the amplitude of the waves during the 1st year of life. In conclusion, these results indicate that the part of the sympathetic nervous system associated with arousal develops during the first 10 wk of life.

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The relationship between postnatal skin maturation and electrical skin impedance

Cited by 9 publications

References 0 publications

Dry Skin of Newborn Infants: Functional Analysis of the Stratum Corneum

Dry Skin of Newborn Infants: Functional Analysis of the Stratum Corneum

In Vitro Differential Diagnosis of Clavus and Verruca by a Predictive Model Generated from Electrical Impedance

Skin Conductance Changes During the First Year of Life in Full-Term Infants

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