The Relationship between Population Iodine Statistics and Iodine Status of Individuals

Brauer, V. F. H.; Paschke, Ralf

doi:10.1016/b978-0-12-374135-6.00043-1

Comprehensive Handbook of Iodine 2009

DOI: 10.1016/b978-0-12-374135-6.00043-1

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The Relationship between Population Iodine Statistics and Iodine Status of Individuals

V. F. H. Brauer

Ralf Paschke

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2014

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“…Therefore, continuous monitoring of iodine status is an essential part of universal salt iodization programs ,, with dietary iodine intake recommended to be 150 μg/day for adults and 250 μg/day for pregnant women . The best single measurement to evaluate median iodine intake in the population is via excreted urinary iodide, which represents more than 90% of the iodine recently ingested. ,,, For this reason, iodide concentrations from random spot urine samples are often used in epidemiological studies for iodine status assessment. However, simple, selective, and cost-effective assays are needed to analyze submicromolar levels of urinary iodide for population health …”

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A Robust Method for Iodine Status Determination in Epidemiological Studies by Capillary Electrophoresis

et al. 2014

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Iodine deficiency is the most common preventable cause of intellectual disabilities in children. Global health initiatives to ensure optimum nutrition thus require continuous monitoring of population-wide iodine intake as determined by urinary excretion of iodide. Current methods to analyze urinary iodide are limited by complicated sample pretreatment, costly infrastructure, and/or poor selectivity, posing restrictions to large-scale epidemiological studies. We describe a simple yet selective method to analyze iodide in volume-restricted human urine specimens stored in biorepositories by capillary electrophoresis (CE) with UV detection. Excellent selectivity is achieved when using an acidic background electrolyte in conjunction with dynamic complexation via α-cyclodextrin in an unmodified fused-silica capillary under reversed polarity. Sample self-stacking is developed as a novel online sample preconcentration method to boost sensitivity with submicromolar detection limits for iodide (S/N ≈ 3, 0.06 μM) directly in urine. This assay also allows for simultaneous analysis of environmental iodide uptake inhibitors, including thiocyanate and nitrate. Rigorous method validation confirmed good linearity (R(2) = 0.9998), dynamic range (0.20 to 4.0 μM), accuracy (average recovery of 93% at three concentration levels) and precision for reliable iodide determination in pooled urine specimens over 29 days of analysis (RSD = 11%, n = 87).

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A Robust Method for Iodine Status Determination in Epidemiological Studies by Capillary Electrophoresis

et al. 2014

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The Relationship between Population Iodine Statistics and Iodine Status of Individuals

Cited by 1 publication

References 44 publications

A Robust Method for Iodine Status Determination in Epidemiological Studies by Capillary Electrophoresis

A Robust Method for Iodine Status Determination in Epidemiological Studies by Capillary Electrophoresis

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