The relationship between particle size and solubility

Buckton, Graham; Beezer, Anthony E.

doi:10.1016/0378-5173(92)90184-4

Cited by 120 publications

(76 citation statements)

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“…It has been well established that the particle size, shape and surface area of pharmaceutical compounds have an important impact on solubility, dissolution and in vivo bioavailability, as well as in helping the design of new drug delivery systems [50,51]. Reducing particle size and higher surface area would enhance the solubility of the solid particles and consequently, would increase the dissolution rate and bioavailability [52]. Thus, it is assumed that the Biofield Energy Treated magnesium gluconate might be dissolved and absorbed at a faster rate and may possibly have more bioavailability than normal magnesium gluconate.…”

Section: Particle Size Distribution (Psd) Analysismentioning

confidence: 99%

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect®) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

IJNFS

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Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect ® -Energy of Consciousness Healing Treatment on the physicochemical, thermal and behavioral properties of magnesium gluconate using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts -one part was control without any Biofield Energy Treatment, while another part was treated with the Biofield Energy Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as the Biofield Energy Treated sample. The PXRD analysis exhibited significant alteration of the crystal morphology of the treated sample compared with the control sample. The crystallite size of the treated sample was remarkably changed from range -33.33% to 66.65% compared with the control sample. The average crystallite size was increased in the treated sample by 6.13% compared with the control sample. Particle size analysis revealed that the particle size at d 10 value was significantly reduced in the treated sample by 13.20% compared with the control sample, although the particle size at d 50 and d 90 values were increased in the treated sample by 2.75% and 3.72%, respectively. The treated sample's surface area was significantly enhanced (6.96%) compared with the control sample. The FT-IR and UV-vis analysis showed that the structure of magnesium gluconate remained similar in both the treated and control samples. The TGA analysis revealed that the weight loss of the first and second degradation steps in the treated sample was significantly decreased by 2.89% and 8.43%, respectively compared with the control sample, whereas at the third degradation step, the weight loss was enhanced by 14.80% compared with the control sample. The DSC analysis revealed that the melting point of the control and treated samples were 170.23°C and 170.25°C, respectively. The latent heat of fusion was significantly decreased by 6.15% in the treated sample compared with the control sample. The current study infers that The Trivedi Effect ® -Energy of Consciousness Healing Treatment might lead to a new polymorphic form of magnesium gluconate, which could be more soluble and bioavailable compared with the untreated compound. Hence, the Biofield Energy

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Section: Particle Size Distribution (Psd) Analysismentioning

confidence: 99%

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect®) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

IJNFS

View full text Add to dashboard Cite

show abstract

“…Reduction in particle size and higher surface area enhance the solubility of the solid particles as well as increase the dissolution rate and bioavailability [46]. Thus, it is predicted that The Trivedi Effect ® -Biofield Energy Treated sodium selenate might be absorbed in faster rate from the gut and thus, can offer more bioavailability than the untreated sample.…”

Section: Particle Size Distribution (Psd) Analysismentioning

confidence: 99%

Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)

Trivedi¹

2017

AJLS

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect ® -Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts -one part was control without any treatment and another part was treated with The Trivedi Effect ® -Biofield Energy Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as The Trivedi Effect ® -Energy of Consciousness Healing Treated sample. The PXRD analysis showed the significant alteration of the crystallite size of the treated sample in the range of -36.36% to 133.24% as compared to the control sample. However, the average crystallite size of the treated sample was significantly decreased by 8.31% as compared to the control sample. Overall, the crystal morphology of the treated sample was different from the control sample. The particle sizes d 10 , d 50 , and d 90 values of the treated sample were significantly decreased by 3.40%, 9.75%, and 8.52%, respectively as compared to the control sample. Consequently, the surface area of the treated sample was significantly increased by 5.26% from the control sample. Both the control and treated FT-IR spectra indicated the presence of sharp and strong absorption bands at 887 cm -1 due to the Se=O stretching. The UV-vis spectroscopic analysis displayed that the wavelength for the maximum absorbance of both the control and treated samples were at 204.1 and 204.0 nm, respectively. TGA analysis revealed that the total weight loss of the treated sample was reduced by 1.24% as compared with the control sample. The DSC analysis showed that the treated sample (588.77°C) had higher melting point than the control sample (588.60°C). The latent heat of fusion was reduced in the treated sample by 8.01% compared to the control sample. Thus, The Trivedi Effect ® -Biofield Energy Healing might lead to generate a new polymorphic (enantiotropic) form of sodium selenate which would be more soluble, bioavailable, and thermally stable compared with the untreated sample. The Trivedi Effect treated sodium selenate would be very useful to design better nutraceutical and/or pharmaceutical formulations that might offer better therapeutic response against inflammatory diseases, immunological disorders, stress, aging, infectious diseases, cancer, diabetes, heart diseases, Alzheimer's disease, etc.

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“…It has been well established that the particle size, shape and surface area of pharmaceutical compounds have an important impact on solubility, dissolution and in vivo bioavailability, as well as supports the designing of new drug delivery systems [51,52]. Reducing the particle size and higher surface area would enhance the solubility of the solid particles, and consequently would increase the dissolution rate and bioavailability [53]. Thus, it is assumed that the Biofield Energy Treated zinc chloride might be dissolved and absorbed at a faster rate and may possibly have more bioavailability than untreated zinc chloride.…”

Section: Particle Size Distribution (Psd) Analysismentioning

confidence: 99%

Evaluation of the Physicochemical, Structural, Thermal, and Behavioral Properties of the Energy of Consciousness Healing Treated Zinc Chloride

Trivedi¹

2017

BIO

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Zinc chloride is a source of zinc used in various pharmaceutical/nutraceutical formulations. The objective of the current study was to investigate the impact of The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physical, structural, thermal, and behavioral properties of zinc chloride using PXRD, PSD, FT-IR, UVvis, and DSC analysis. Zinc chloride was divided into two parts -one part was control, while another part was treated with The Trivedi Effect ® remotely by twenty renowned Biofield Energy Healers and defined as The Trivedi Effect ® Treated sample. A significant alteration of the crystallite size and relative intensities of the PXRD peaks was observed in The Trivedi Effect ® treated sample compared with the control sample. The average crystallite size of the treated sample was significantly increased by 23.18% compared with the control sample. The particle size values at d 10 , d 50 , and d 90 values were significantly decreased by 3.70%, 4.13%, and 6.13%, respectively in the treated sample compared with the control sample. Therefore, the surface area of the treated sample was increased by 4.21% compared with the control sample. The FT-IR spectroscopic analysis revealed that Zn-Cl stretching in the control sample was found at 512 cm -1 , whereas it was significantly shifted upward to 520 cm -1 in the treated sample. The UV-vis analysis exhibited that wavelength of the maximum absorbance (λ max ) of the control and treated samples were at 197.6 nm and 197.1 nm, respectively. The DSC analysis exhibited that the melting temperature was decreased by 0.22%, while decomposition temperature was increased by 2.56% in the treated sample compared to the control sample. The latent heat of fusion of the treated sample (320.44 J/g) was significantly decreased by 16.70% compared with the control sample (284.67 J/g). Similarly, the enthalpy of decomposition of the treated sample (952.53 J/g) was significantly increased by 122.61% compared with the control sample (427.90 J/g). Thus, the results indicated that the thermal stability of the treated zinc chloride was improved compared with the control sample. The current study anticipated that The Trivedi Effect ® -Energy of Consciousness Healing Treatment might lead to produce a thermally stable new polymorphic form of zinc chloride, which would be more soluble and bioavailable compared with the untreated compound. Hence, the treated zinc chloride would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic response against American Journal of Bioscience and Bioengineering 2017; 5(2): 65-74 66 inflammatory diseases, immunological disorders, aging, stress, cancer, etc.

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The relationship between particle size and solubility

Cited by 120 publications

References 1 publication

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect<sup>®</sup>) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect<sup>®</sup>) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

Evaluation of the Physicochemical, Structural, Thermal, and Behavioral Properties of the Energy of Consciousness Healing Treated Zinc Chloride

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The relationship between particle size and solubility

Cited by 120 publications

References 1 publication

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;)

Evaluation of the Physicochemical, Structural, Thermal, and Behavioral Properties of the Energy of Consciousness Healing Treated Zinc Chloride

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Product

Resources

About

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect<sup>®</sup>) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect<sup>®</sup>) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate

Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)