The relationship between nitric oxide production and activity of the disease in patients with psoriasis

Örem, Asım; Aliyazıcıoğlu, Rezzan; Kiran, Emine; Vanizor, Birgül; Çimnocodeit, Gülseren

doi:10.1001/archderm.133.12.1606

Cited by 20 publications

(20 citation statements)

References 3 publications

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“…Increase in mRNA expression of iNOS in skin lesions as compared to uninvolved skin have been reported [29]. Orem Asim et al [30] observed that nitrite levels and nitrite-nitrate ratios appear to be good indicators for the increased NO • production in patients and also showed a significant correlation with PASI.…”

Section: Resultsmentioning

confidence: 84%

Role of Oxidative Stress in Various Stages of Psoriasis

et al. 2010

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Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently, it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects) and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects. As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and decreased antioxidant potential in psoriasis.

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Section: Resultsmentioning

confidence: 84%

Role of Oxidative Stress in Various Stages of Psoriasis

et al. 2010

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“…One of the reason for increased NO production is believed to be the association with inflammatory processes as observed in many previous studies [16, 17]and in psoriatic patients [18]. Increased NO production is thus expected in patients with Behçet’s disease in the acute inflammatory stage.…”

Section: Discussionmentioning

confidence: 81%

Decreased Nitric Oxide Production in Patients with Behçet’s Disease

Örem¹,

Vanizor²,

Çimşit

et al. 1999

Dermatology

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Background: Behçet’s disease is a chronic multisystemic disorder which is characterized by a relapsing systemic inflammatory process. One of the features of Behçet’s disease is endothelial dysfunction resulting from many factors. Objective and Methods: We conducted this study to show if there is any change of plasma nitrite and nitrate levels by using the enzymatic-spectrophotometric method as an indicator for nitric oxide (NO) production, considering the disease activity in patients with Behçet’s disease. The study group consisted 21 patients and 20 healthy control subjects. We measured plasma nitrite and nitrate levels, and some acute-phase reactants including erythrocyte sedimentation rate, alpha-1-antitrypsin, alpha-2-macroglobulin and the neutrophil count. Blood samples were drawn before and after treatment of the patients. Results: Nitrite, nitrate and nitrite + nitrate levels in the active period of the disease were found to be decreased compared to the inactive period and the control group. No significant differences were observed in plasma nitrite and nitrate levels between the inactive period and the control group. Conclusion: It was concluded that decreased NO production in patients with Behçet’s disease may have critical biological activities relevant to pathologic events in the active period of the disease.

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“…They showed that in healthy human skin, NO is released at relatively low levels, due mainly to chemical reactions occurring within the sweat layer that covers the skin. By contrast, NO is released from psoriatic plaques at a rate about 100 times greater (Orem et al, 1997;Weller and Ormerod, 1997;Ormerod et al, 1998).…”

Section: Introductionmentioning

confidence: 92%

Modelling Blood Flow Regulation by Nitric Oxide in Psoriatic Plaques

Sherratt

Weller

Savill

2002

Bulletin of Mathematical Biology

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Psoriasis is a common skin disease, with a clinical appearance of red, scaly lesions, known as plaques. Recent experimental research has shown that the ubiquitous cellsignalling molecule nitric oxide (NO) is actively synthesized within these plaques by the iNOS enzyme. In contrast, NO production from normal, healthy skin is a byproduct of the reduction of nitrite in sweat. Measurement of NO release rates at the skin surface are 100 times greater from psoriatic lesions than normal skin. We propose a mathematical model for the dynamics of NO within psoriatic plaques, that incorporates diffusion, production in the basal epidermis, decay within the plaque, and active scavenging by red blood cell haemoglobin; this last effect introduces a key nonlinearity into the model. We present numerical simulations of the model in two space dimensions, and then describe an approximation that reduces the model to two coupled ordinary differential equations. This reduced system can be solved exactly, giving an approximation for the NO release rate as an explicit function of model parameters. We use this approximation to explain some recent, surprising experimental results.

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The relationship between nitric oxide production and activity of the disease in patients with psoriasis

Cited by 20 publications

References 3 publications

Role of Oxidative Stress in Various Stages of Psoriasis

Role of Oxidative Stress in Various Stages of Psoriasis

Decreased Nitric Oxide Production in Patients with Behçet’s Disease

Modelling Blood Flow Regulation by Nitric Oxide in Psoriatic Plaques

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