The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus

Abstract

To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann–Whitney U test, or χ2 test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis.The values of triglyceride (TG), neutrophils, fasting insulin, urinary albumin, and 2 hour postglucose in DPN group were significantly higher than those of the DM group, whereas the number of lymphocytes of DPN group was considerably lower than that of the DM group (P < .05 respectively); NLR values were remarkably higher in DPN group compared with those of DM group (2.58 ± 0.50 vs 2.18 ± 0.61, P < .001); logistic regression analysis showed that NLR (P = .002, OR = 4.960, 95% CI = 1.843–13.349) was a risk factor of DPN. Multivariate logistic regression analysis showed that DPN was independently related to NLR (P = .002, OR = 4.960, 95% CI = 1.843–13.349). The ROC curve analysis confirmed that the optimal cut-off point, specificity, and sensitivity in diagnosing DPN by NLR were 2.13%, 48.1%, and 81.3% respectively.Our results showed that NLR is significantly correlated with DPN, which suggested that NLR may be an independent risk factor of DPN.

The effect of using tadalafil 5 mg/day on neutrophil–lymphocyte and platelet–lymphocyte ratios in mild‐medium and severe erectile dysfunction patients; and comparison of clinical response

“…For this purpose, the fasting blood glucose, lipid profile, complete blood count and total testosterone level that are requested by clinicians are among these tests (Burnett, ). Studies conducted on NLR and PLR values, which show the relation between systemic inflammation and many diseases in ED and aetiology, are increasing in the present literature (Furuncuoğlu et al, ; İdil Soylu et al, ; Meng et al, ; Tulgar et al, ; Varım et al, ; Xu et al, ). When we selected our study group, we included not only the pre‐treatment values, but also those who were asked for a CBC for any reason to determine the changes in the 1st month after PDE5i treatment, which is different from previous studies.…”

“…Xu et al conducted a study and compared 160 Type 2 DM patients with diabetic polyneuropathy (DPN) and 397 Type 2 DM patients without polyneuropathy and found that mean NLR value was higher at a significant level in DPN group (2.58 ± 0.50 vs. 2.18 ± 0.61, p < 0.001) and stated that it could be an independent risk factor ( p = 0.002, OR = 4.960, 95% CI = 1.843–13.349) (Xu et al, ). Horne et al conducted a study with 3,227 patients and found that NLR was an independent predictor of cardiovascular risk (HR 2.2, p < 0.001) (Horne et al, ).…”

“…In recent years, publications indicating that active inflammatory processes cause ED are increasing. In these studies where neutrophil–lymphocyte (NLR) and platelet–lymphocyte ratios (PLR) were used as signs of inflammation, a significant relationship was found between diseases with these proportions (Furuncuoğlu et al, ; İdil Soylu et al, ; Meng et al, ; Sambel et al, ; Tulgar et al, ; Varım et al, ; Xu et al, ).…”

Neutrophil‐lymphocyte ratio as a predictor of kidney function decline among individuals with diabetes and prediabetes: A 3‐year follow‐up study

“…Recent studies confirmed that the NLR is closely related to the risk of diabetes and diabetic complications . However, the predictive value of the NLR for the risk of diabetic nephropathy and kidney function decline is still not clear.…”

“…Recent studies confirmed that the NLR is closely related to the risk of diabetes and diabetic complications. 2,7,8 However, the predictive value of the NLR for the risk of diabetic nephropathy and kidney function decline is still not clear. Based on a large-scale prospective study, we found that NLR was an independent predictive factor for kidney function decline among individuals with diabetes and prediabetes.…”