The relationship between malnutrition risk and clinical outcomes in a cohort of frail older hospital patients

Slee, Adrian; Birch, Deborah; Stokoe, David

doi:10.1016/j.clnesp.2016.06.002

Cited by 24 publications

(19 citation statements)

References 28 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low BMI was significantly associated with ICU admission, but not to other outcomes. Previous studies have found low BMI to be a predictor of adverse events, including mortality among hospitalized patients . Low albumin was significantly associated with increased number of MET‐calls and length of stay, consistent with findings from previous studies with hospitalized patients …”

Section: Discussionsupporting

confidence: 90%

Clinical impact of frailty among patients with severe vital sign derangement: An observational study

Bech

Lindhardt

Meyhoff

2020

Acta Anaesthesiol Scand

View full text Add to dashboard

Background Frailty is associated with increased morbidity and mortality and frail patients may have reduced ability to tolerate severe vital sign derangement such as estimated by a high National Early Warning Score (NEWS). The clinical impact of frailty among patients that develop high NEWS during hospital admissions is sparsely studied. The aim of this study was to investigate the association between clinical frailty and admission to intensive care unit (ICU) among these patients. Methods We conducted a prospective observational study from November 2017 to January 2018. We included adult patients admitted to general wards that during hospitalization developed severe vital sign derangement defined as NEWS ≥7. Patients were without treatment restrictions at inclusion. Primary exposure was frailty as assessed by the Clinical Frailty Scale. Primary outcome was ICU admission within 90 days, which was analyzed using multivariate logistic regression. Results We included 109 patients with NEWS ≥7, of which 61 patients (56%) were frail. Ten of the 61 frail patients (16%) were admitted to ICU compared to 9 of the 48 non‐frail patients (19%), adjusted odds ratio (aOR) 0.92 (95% CI 0.32‐2.62). Frail patients were more likely to have new treatment restrictions (aOR 2.91; 95% CI 1.26‐6.71). Their aOR for mortality was 1.95 (95% CI 0.84‐4.55). Conclusion Frail patients with severe vital sign derangement during acute hospital admissions were not more likely to be admitted to ICU nor was mortality higher. Treatment restrictions were more frequent among frail patients after vital sign derangements developed.

show abstract

Section: Discussionsupporting

confidence: 90%

Clinical impact of frailty among patients with severe vital sign derangement: An observational study

Bech

Lindhardt

Meyhoff

2020

Acta Anaesthesiol Scand

View full text Add to dashboard

show abstract

“…Several previous studies supported the associations of serum albumin with physical functional capacity, sarcopenia, and frailty. [32][33][34] Taken together, these findings suggest that grip strength should be considered copyright.…”

Section: Discussionmentioning

confidence: 94%

Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength

Yokoyama¹,

Shiraiwa²,

Takahara

et al. 2020

BMJ Open Diab Res Care

View full text Add to dashboard

IntroductionProgression of muscle strength weakening will lead to a poor physical performance and disability. While this is particularly important in patients with diabetes, the associations of reduced muscle strength measured by grip strength with clinical features and physical performance remain unclear. We investigated clinical features and physical performance measures in association with grip strength in elderly people with diabetes in a primary care setting.Research design and methodsA cross-sectional study was conducted enrolling 634 male and 323 female Japanese patients with type 2 diabetes aged 60 years or older. First, grip strength was measured and the associations of gender-specific grip strength with clinical features were evaluated. Second, in patients with a grip strength below the gender-specific median, physical performance measures, including gait speed, timed chair stand speed, knee extension strength, standing balance, and short physical performance battery scores, were investigated. Patients with and without a low performance defined by Asian Working Group for Sarcopenia were compared in terms of clinical features and physical performance measures.ResultsGrip strength decreased according to aging and longer duration of diabetes and was independently related to body mass index, glycated hemoglobin A1c (HbA1c), serum albumin, albuminuria, neuropathy, and stroke in male patients, and to body mass index and albuminuria in female patients. The physical performance measures became worse proportionally to a decrease in the grip strength. Patients with a low performance exhibited a significantly older age, lower grip strength and serum albumin, higher albuminuria, and poorer physical performance measures than those without.ConclusionsReduced grip strength was associated with glycemic exposure indicators of age-related duration, HbA1c, and vascular complications. The physical performance measures became worse with decreasing grip strength. Measurements of grip strength and physical performance in patients with diabetes may help promote intervention to prevent frailty in future studies.

show abstract

“…However, there was a negative correlation between death and albumin levels in SDG (Table 6); therefore, in dogs with critical diseases, hypoalbuminemia indicates a higher chance of death. In the literature, reports of correlations between low concentrations of albumin and high mortality are extensive (Nakajima et al 2014, Wang et al 2014, Garwe et al 2016, Slee 2016).…”

Section: Mortalitymentioning

confidence: 99%

Determination of the reference interval of the C-reactive protein/albumin ratio and its efficiency, CRP and albumin as prognostic markers in dogs

Fabretti

Siqueira

Amaral³

et al. 2020

Pesq. Vet. Bras.

View full text Add to dashboard

The objective of this research was to creates a reference interval for C-reactive protein (CRP)/albumin ratio (CAR) in the canine species and to analyze the potential of CRP, albumin and the relationship between both, to serve as indicators of disease severity, length of hospital stay (LoS) and mortality in this species. For this, an outcome study was conducted in a Veterinary Teaching Hospital in southern Brazil. One hundred ninety dogs were included randomly, without distinction of gender, age, or breed, from June 2013 to November 2016. Plasma was collected from them and analyzed for assessment of CRP and albumin. The reference range stipulated for CAR in dogs was 0.36-0.60, as determined by the confidence interval of mean resamplings (in percentiles). The frequencies mean, and standard deviations of the variables, correlation analysis, and comparative analysis (Kruskal-Wallis in α = 5%) were calculated. Elevation (above reference) of CAR was determined to be proportional to the severity of the underlying disease, and CRP means were reasonable. Besides, hypoalbuminemia was indicative of systemic disease, but not of severity. Thus, CAR was a better marker of disease severity than were CRP and albumin, analyzed separately. Concerning LoS, there was a positive correlation with CAR (p<0.01) in patients, and the same was not observed with CRP and albumin. Concerning mortality, hypoalbuminemia was the only marker valid in animals with a critical illness (p=0.04). In conclusion, CAR is a better marker of disease severity and LoS in dogs than are CRP and albumin analyzed separately.

show abstract

The relationship between malnutrition risk and clinical outcomes in a cohort of frail older hospital patients

Abstract: 22

Cited by 24 publications

References 28 publications

Clinical impact of frailty among patients with severe vital sign derangement: An observational study

Clinical impact of frailty among patients with severe vital sign derangement: An observational study

Applications of physical performance measures to routine diabetes care for frailty prevention concept: fundamental data with grip strength, gait speed, timed chair stand speed, standing balance, and knee extension strength

Determination of the reference interval of the C-reactive protein/albumin ratio and its efficiency, CRP and albumin as prognostic markers in dogs

Contact Info

Product

Resources

About