The Relationship between Leukocyte Mitochondrial DNA Copy Number and Telomere Length in Community-Dwelling Elderly Women

Kim, Jung‐Ha; Kim, Hye Kyung; Ko, Jae‐Hong; Bang, Hyoweon; Lee, Duk Chul

doi:10.1371/journal.pone.0067227

Cited by 85 publications

(85 citation statements)

References 46 publications

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“…The present study identified that TL is positively correlated with mtCN in GC tissues and paired normal tissues; this was consistent with the results of previous studies conducted on healthy volunteers (15)(16)(17). A correlation between TL and mtCN was initially identified in a study of 129 healthy elderly females (15); in a further study, it was also demonstrated in healthy adults and pregnant females (16,17).…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, TL was marginally shorter in intestinal type GC, as compared with in diffuse type GC, whereas TL and mtCN did not have any significant association with clinical characteristics. However, a notable association was identified in GC tissues; in accordance with previous studies on healthy individuals (15)(16)(17)25), mtCN and TL were identified to be correlated with each other in normal and cancerous tissues obtained from patients with GC. A positive association was also identified in intestinal type GC, but not in the diffuse type.…”

Section: Discussionsupporting

confidence: 89%

“…A correlation between TL and mtCN was initially identified in a study of 129 healthy elderly females (15); in a further study, it was also demonstrated in healthy adults and pregnant females (16,17). Furthermore, certain neuropsychiatric conditions were also associated with TL shortening and mtCN increase, although detailed data concerning their association were not presented (25).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have indicated that TL and mtCN are positively correlated in healthy individuals and in pregnant females (15)(16)(17). Genetic changes in the telomeres and mtDNA independently serve important roles in cellular senescence (18).…”

Section: Introductionmentioning

confidence: 99%

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Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer

et al. 2017

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Abstract.A positive correlation between telomere length and mitochondrial DNA (mtDNA) copy number has previously been observed in healthy individuals, and in patients with psychiatric disorders. In the present study, telomere length and mtDNA copy number were evaluated in gastric cancer (GC) tissue samples. DNA was extracted from 109 GC samples (including 82 intestinal, and 27 diffuse cases), and the telomere length and mtDNA copy number were analyzed using a quantitative-polymerase chain reaction assay. The relative telomere length and mtDNA copy number in tumor tissue, as compared with in normal tissue, (mean ± standard deviation) in all GC samples were 11.48±1.14 and 14.86±1.35, respectively. Telomere length and mtDNA copy number were not identified as exhibiting clinical or prognostic value for GC. However, positive correlations between telomere length and mitochondrial DNA copy number were identified in GC (r=0.408, P<0.001) and in the adjacent normal mucosa (r=0.363; P<0.001). When stratified by Lauren classification, the correlation was identified in intestinal type GC samples (r=0.461; P<0.001), but not in diffuse type GC samples (r= 0.225; P= 0.260). This result indicated that loss of the correlation of telomeres and mitochondrial function may induce the initiation or progression of GC pathogenesis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer

et al. 2017

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“…Reduced mtDNAcn has been reported in post-traumatic stress disorder 47 and in relation to depressive symptoms among elderly communitydwelling women without MDD. 48,49 Higher leukocyte mtDNA-cn has been reported in autism 50 and lifetime psychopathology in healthy people. 51 MtDNA-cn has been found to be lower 52 and unchanged 53 in bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Stress: A deadly weapon

Peñagarikano

2016

Sci. Transl. Med.

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Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the bloodstream. Major depressive disorder has been associated with an increased amount of mtDNA in leukocytes from saliva samples and blood; however, no previous studies have measured plasma levels of free-circulating mtDNA in a clinical psychiatric sample. In this study, free circulating mtDNA was quantified in plasma samples from 37 suicide attempters, who had undergone a dexamethasone suppression test (DST), and 37 healthy controls. We hypothesized that free circulating mtDNA would be elevated in the suicide attempters and would be associated with hypothalamic-pituitaryadrenal (HPA)-axis hyperactivity. Suicide attempters had significantly higher plasma levels of free-circulating mtDNA compared with healthy controls at different time points (pre-and post-DST; all P-values o2.98E − 12, Cohen's d ranging from 2.55 to 4.01). Pre-DST plasma levels of mtDNA were positively correlated with post-DST cortisol levels (rho = 0.49, P o 0.003). Suicide attempters may have elevated plasma levels of free-circulating mtDNA, which are related to impaired HPA-axis negative feedback. This peripheral index is consistent with an increased cellular or mitochondrial damage. The specific cells and tissues contributing to plasma levels of free-circulating mtDNA are not known, as is the specificity of this finding for suicide attempters. Future studies are needed in order to better understand the relevance of increased free-circulating mtDNA in relation to the pathophysiology underlying suicidal behavior and depression.

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