The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan

Shih, Yu-Lin; Shih, Chin-Chuan; Huang, Tzu-Cheng; Chen, Jau-Yuan

doi:10.3390/biomedicines11020378

Cited by 5 publications

(4 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A meta-analysis has shown that both active and passive smoking can negatively impact HDL [ 4 ]. This is due to several factors, including higher homocysteine levels in smokers, which hurts HDL [ 29 ]. Additionally, smoking may reduce estrogen levels, leading to a decrease in HDL [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Association between lipid profiles and cigarette smoke among adults in the Persian cohort (Shahedieh) study

Momayyezi,

Jambarsang,

Fallahzadeh

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

Objectives Exposure to cigarette smoke introduces a large amount of nicotine into the bloodstream through the lungs. So, smoking can be a risk factor for many diseases. The present study was conducted to investigate the effect of active and passive cigarette smoke on the blood lipid profile and dyslipidemia. Methods This cross-sectional study was performed on 5052 individuals who participated in the recruitment phase of the Shahedieh cohort study. A logistic regression model was used to investigate the relationship between smoking exposure status and lipid profiles. Results The prevalence of abnormal low-density lipoprotein-cholesterol (LDL-C), abnormal HDL-C, abnormal total cholesterol (TC), abnormal triglyceride (TG), and dyslipidemia were 254 (5.00%), 562 (11.10%), 470 (9.30%), 1008 (20.00%), and 1527 (30.20%), respectively. Adjusting for confounders, it was observed that current smokers had higher odds of having abnormal HDL-C [OR (95% CI), 2.90 (2.28–3.69)], abnormal TG [OR (95% CI), 1.71 (1.38–2.13)] and dyslipidemia [OR (95% CI), 1.86 (1.53–2.25)]. Ex-smokers also had greater odds of abnormal HDL-C [OR (95% CI), 1.51 (1.06–2.16)] compared to non-smokers who were not exposed to cigarette smoke. Conclusions The findings indicated that current smokers had higher TG and lower HDL. So, necessary measures should be taken to reduce smoking. The findings also showed that the prevalence of abnormal TG and HDL in ex-smokers was lower than in current smokers. Therefore, the existence of incentive policies to quit smoking seems necessary.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between lipid profiles and cigarette smoke among adults in the Persian cohort (Shahedieh) study

Momayyezi,

Jambarsang,

Fallahzadeh

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

show abstract

“…Homocysteine emerges as a promising biomarker for cardiovascular disease, potentially pivotal in linking metabolic syndrome with cardiovascular conditions. Elevated homocysteine levels are thought to inflict damage upon endothelial cells [ 4 ]. A recent investigation found that increased levels of insulin can disrupt the processing of homocysteine, resulting in higher concentrations of this compound.…”

Section: Introductionmentioning

confidence: 99%

“…A recent investigation found that increased levels of insulin can disrupt the processing of homocysteine, resulting in higher concentrations of this compound. In metabolic syndrome, insulin resistance manifests as elevated insulin levels [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

Tarcau,

Negru,

Ghitea

et al. 2024

Biomedicines

View full text Add to dashboard Cite

This study investigates the distribution of hyperhomocysteinemia and cardiovascular metabolic syndrome (SM) among participants, shedding light on their prevalence and co-occurrence within the study cohort. Through an analysis of demographic characteristics and health parameters, including age, gender, and body mass index (BMI), alongside nutritional data, correlations between these factors and health risks are explored. Results reveal a notable prevalence of hyperhomocysteinemia, with 45.3% of participants exhibiting this condition. Furthermore, 31.4% of the cohort does not present hyperhomocysteinemia or SM, while 23.3% shows SM without hyperhomocysteinemia. The study underscores gender-specific dietary recommendations due to significant variations in nutrient intake patterns. Additionally, inverse correlations between health risks like obesity, hypertension, and hypercholesterolemia and nutrient requirements highlight the need for tailored dietary interventions. Age-related changes in nutrient needs and the positive correlation between physical activity levels and certain nutrient demands further emphasize the importance of personalized dietary strategies. Variations in nutrient intake by gender, inverse correlations with health risks, and age-related changes underscore the need for tailored dietary strategies. These findings provide valuable insights for healthcare professionals in developing targeted nutritional interventions to mitigate disease risk and promote overall health and well-being.

show abstract

“…This study is expected to contribute significantly to the disease management and prevention of middle-aged and elderly adults receiving primary health care. Several publications have already been published based on this database, and this paper is no exception [22][23][24][25][26][27]. This study aimed to investigate differences in the relationship of vitamin D levels with sitting time between middle-aged and older adult populations in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Self-Reported Sitting Time and Vitamin D Levels in Middle-Aged and Elderly Taiwanese Population: A Community-Based Cross-Sectional Study

Chang,

Lin,

Shih

et al. 2023

Nutrients

Self Cite

View full text Add to dashboard Cite

(1) Background: Many studies have revealed a relationship between serum 25-hydroxy vitamin D and physical activity. This study aimed to investigate the relationship between self-reported sitting time and serum 25-hydroxy vitamin D levels in middle-aged and elderly adults in Taiwan. (2) Methods: A total of 396 people were enrolled in our study during a community health examination in Taiwan in 2019. We grouped participants from low to high according to their tertile of serum 25-hydroxy vitamin D levels, using the following categories: deficiency, insufficiency, and sufficiency. Parameters including self-reported sitting time were analyzed between each group. Pearson correlation coefficients were calculated to explore the relationships of serum 25-hydroxy vitamin D levels with age-adjusted risk factors. A scatter plot demonstrated the relationship between serum 25-hydroxy vitamin D levels and self-reported sitting time. The association between serum 25-hydroxy vitamin D levels and self-reported sitting time was assessed by multivariate linear regression with adjustment for age, sex, waist circumference, low-density lipoprotein, triglycerides, and smoking and drinking status. (3) Results: We analyzed the data from 396 participants. A total of 41.4% of participants were male, and the average age of all participants was 64.91 (±8.80) years. The participants in the high serum 25-hydroxy vitamin D group were more likely to have shorter self-reported sitting time. Serum 25-hydroxy vitamin D was negatively correlated (Pearson’s r) with self-reported sitting time, even after adjustment for age. According to the results of multivariate linear regression, vitamin D levels showed a negative association with self-reported sitting time (β = −0.131, p = 0.006) after adjustment for age, sex, waist circumference, low-density lipoprotein, triglycerides, and smoking and drinking status. (4) Conclusions: According to our research, self-reported sitting time was inversely correlated with serum 25-hydroxy vitamin D in middle-aged and elderly people in Taiwan. Meanwhile, longer self-reported sitting time can be an independent risk factor for lower serum 25-hydroxy vitamin D levels.

show abstract

The Relationship between Elevated Homocysteine and Metabolic Syndrome in a Community-Dwelling Middle-Aged and Elderly Population in Taiwan

Cited by 5 publications

References 47 publications

Association between lipid profiles and cigarette smoke among adults in the Persian cohort (Shahedieh) study

Association between lipid profiles and cigarette smoke among adults in the Persian cohort (Shahedieh) study

Is There a Connection between Hyperhomocysteinemia and the Cardiometabolic Syndrome?

The Relationship between Self-Reported Sitting Time and Vitamin D Levels in Middle-Aged and Elderly Taiwanese Population: A Community-Based Cross-Sectional Study

Contact Info

Product

Resources

About