The relationship between carotid intima–media thickness and global atherosclerosis

Lundberg, Christer; Hansen, Tomas; Åhlström, Håkan; Lind, Lars; Wikström, Johan; Johansson, Lars

doi:10.1111/cpf.12116

Cited by 14 publications

(10 citation statements)

References 27 publications

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“…The research by Veller et al 22 reported that, among individuals whose CIMT was greater than 0.8 mm, 95.5% had plaque in their aorta. The research by Lundberg et al 29 suggested that CIMT was related to overall stenoses in the body, even after adjustment for traditional risk factors, confirming CIMT as an indicator of general atherosclerosis. Taken together, the independent correlation between CIMT and PTT in the thickened CIMT hypertensive group may suggest that rcPTT and acPTT could be useful adjunctive markers in reflecting the degree of atherosclerosis.…”

Section: Discussionmentioning

confidence: 93%

The relationship between heart-carotid pulse transit time and carotid intima-media thickness in hypertensive patients

Xiong

et al. 2015

J Hum Hypertens

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The study aimed to investigate the relationship between heart-carotid pulse transit time and carotid intima-media thickness (CIMT) in hypertensive patients, and whether including the pre-ejection period (PEP) in heart-carotid pulse transit time would affect this correlation. A total of 62 hypertensive patients were included in this study. They were divided into the normal CIMT group (n=33, CIMT⩽0.8 mm) and the thickened CIMT group (n=29, CIMT>0.8 mm). The noninvasive ultrasound method was used to measure CIMT, electrocardiogram R-wave-based heart-carotid pulse transit time (rcPTT) and PEP. Aortic valve-carotid artery pulse transit time (acPTT) was calculated by subtracting PEP from rcPTT. Simple linear analysis showed that CIMT was negatively associated with rcPTT and acPTT (r=-0.57, P<0.0001; r=-0.41, P=0.016) in the normal CIMT group as well as in the thickened CIMT group (r=-0.50, P=0.0053; r=-0.59, P=0.001). These relationships were eliminated in the normal CIMT group after adjusting for age, gender, smoking behaviour, systolic blood pressure, diastolic blood pressure and cholesterol levels. However, rcPTT and acPTT still showed significant correlations with CIMT in the thickened CIMT group. In conclusion, rcPTT and acPTT were associated with CIMT, independent of well-known clinical confounders in thickened CIMT hypertensive patients. Therefore, rcPTT and acPTT might be useful markers for atherosclerosis evaluation.

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Section: Discussionmentioning

confidence: 93%

The relationship between heart-carotid pulse transit time and carotid intima-media thickness in hypertensive patients

Xiong

et al. 2015

J Hum Hypertens

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“…Our results match with data from the medical literature. [6][7][8] From our data, we can state that the most severely affected coronaries were found in the diabetes group. The same result was found in similar studies.…”

Section: Discussionmentioning

confidence: 96%

Plurivascular Lesions in Patients with Peripheral Arterial Disease

Kelemen

Kolbert

Szabó

et al. 2016

Journal of Interdisciplinary Medicine

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Introduction: Occlusive arterial disease, regardless of etiology, is a progressive chronic disease with multiple vessel involvement. The importance of obstructive arterial disease is that it leads to an increased mortality and morbidity of other cardiovascular disorders. Therefore, the presence of a lesion on a certain artery should lead to the identification of other lesions on the carotid and coronary arteries. The aim of the study was to assess the frequency and severity of lesions in peripheral arterial disease of different etiologies, and also to study its association with multivessel lesions at the level of the coronary tree and the carotid arteries. Material and methods:We performed a retrospective study on 177 patients with previously diagnosed peripheral artery disease that were admitted to the 2 nd Medical Clinic of the County Emergency Clinical Hospital of Tîrgu Mureș. The patients underwent evaluation of the peripheral artery disease (clinical, arterial Doppler), as well as of the coronary artery disease (clinical, ECG) and the carotid arteries (auscultation, Doppler Duplex ultrasound). The study population was divided into three groups: group 1 -diabetic arteriopathy (n = 79); group 2 -atherosclerotic obstructive arteriopathy (n = 77); group 3 -thromboangiitis obliterans (n = 21). Results: The patients' age ranged between 61 and 70 years. Arterial occlusions were found in 87% of cases in group 1. Suboclussions were more frequent in diabetics (11.4%). The artery, in which we found lesions in the highest percentage was the left femoral artery (group 1 -68.3%, group 2 -66.23%, group 3 -42.85%). The second most often affected artery was the right femoral artery, with a 64.45% rate of involvement. In patients with thromboangiitis obliterans, the right anterior tibial artery was the most frequently affected (15.81%). The most frequent coronary lesion was a stenosis of 30-69%, in 35.02% of cases. Three-vessel coronary disease had an incidence of 44.2% in the atherosclerotic group, 34.2% in diabetics, and 23.8% in the thromboangiitis group. From the total rate of previously diagnosed myocardial infarction (MI) -29.37% (n = 52), 50% were atherosclerotic, 44.23% diabetic, and 5.76% with thromboangiitis. At the level of the carotid system, 68.9% of patients were found to have stenoses under 70%. From these, 48.4% were patients with diabetic arteriopathy, 44.3% with atherosclerotic disease. In 73.4% of cases, we found lesions at all three levels -in case of diabetic and nondiabetic arteriopathy and thromboangiitis, only 14.3% of patients had associated lesions. Conclusions: Atherosclerosis (diabetic and nondiabetic) and thromboangiitis obliterans are diseases with plurivascular involvement. It is important to diagnose concomitant coronary and carotid lesions in patients with chronic occlusive arterial illness, because they are often associated.

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“…TAS is related to IMT in the PIVUS population, with a significant relationship ( P = 0·0001) even after adjusting for traditional cardiovascular risk factors (Lundberg et al ., ). It has been claimed that increased IMT is more likely to be caused by hypertension, rather than being part of the atherosclerotic plaque process.…”

Section: Discussionmentioning

confidence: 97%

Total atherosclerotic burden measured by magnetic resonance imaging is related to five‐year decline in cognitive function

Hansen

Kilander

Åhlström

et al. 2017

Clin Physio Funct Imaging

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The relationship between carotid intima–media thickness and global atherosclerosis

Cited by 14 publications

References 27 publications

The relationship between heart-carotid pulse transit time and carotid intima-media thickness in hypertensive patients

The relationship between heart-carotid pulse transit time and carotid intima-media thickness in hypertensive patients

Plurivascular Lesions in Patients with Peripheral Arterial Disease

Total atherosclerotic burden measured by magnetic resonance imaging is related to five‐year decline in cognitive function

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