The Relationship Between Carotid Intima-Media Thickness and the Activity of Rheumatoid Arthritis

Targońska-Stępniak, Bożena; Drelich-Zbroja, Anna; Majdan, Maria

doi:10.1097/rhu.0b013e3182290dbf

Cited by 32 publications

(26 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and stated that age, systolic blood pressure, tender joint count, and swollen joint count had significant correlations with patient's CIMT. Also the results reported by Targon´ska-Stepniak (22) are consistent with us who stated that in RA patients, CIMT correlated positively with a number of immunological and inflammatory parameters and also with amino-terminal pro-brain natriuretic peptide (NT-proBNP), age, and metabolic variables (serum cholesterol, creatinine, cystatin C). In multiple linear regression analysis, significant association was found between CIMT and NT-proBNP and age.…”

Section: Discussionsupporting

confidence: 87%

Brachial artery flow mediated dilatation and carotid intima media thickness measured by high resolution B-mode ultrasound in patients with rheumatoid arthritis

Amin

Salama

Elaggan

et al. 2015

The Egyptian Journal of Radiology and Nuclear Medicine

View full text Add to dashboard Cite

Objectives: Firstly to assess the prevalence of subclinical atherosclerosis and endothelial dysfunction by high resolution ultrasound measurements of carotid intima media thickness (CIMT) and brachial artery flow mediated dilatation percentage (FMD%) in patients with rheumatoid arthritis (RA), secondly to analyze the correlation of CIMT and FMD% with different clinical and laboratory parameters, third aim was to analyze the relationship between CIMT and FMD%. Patients and methods: The prospective case-control study included 50 patients with RA and 50 healthy age and sex matched controls. All participants were subjected to carotid and brachial arteries ultrasound for measuring CIMT and FMD%, in addition to detailed history and physical examination.Results: Patients with RA had significantly higher CIMT and significantly lower FMD% than the controls (P < 0.001). In RA patients a significant correlation was found between CIMT and the patient's age, disease duration, systolic blood pressure, HAQ, DAS, CRP and HDL-c, however no detectable correlation between the brachial artery FMD% and the clinical and laboratory parameters in RA patients. There was no significant correlation between CIMT and FMD%. Conclusion: FMD% and CIMT are important non-invasive independent imaging methods for early prediction of subclinical atherosclerosis in RA patients.

show abstract

Section: Discussionsupporting

confidence: 87%

Brachial artery flow mediated dilatation and carotid intima media thickness measured by high resolution B-mode ultrasound in patients with rheumatoid arthritis

Amin

Salama

Elaggan

et al. 2015

The Egyptian Journal of Radiology and Nuclear Medicine

View full text Add to dashboard Cite

show abstract

“…long disease duration, degenerations, high inflammatory parameters, and extra-articular manifestations). 28 However, in this study, carotid IMT values were not associated with disease severity in FM patients.…”

Section: Discussioncontrasting

confidence: 67%

Increased Carotid Intima-Media Thickness in Female Patients With Fibromyalgia: A Preliminary Study

Bölük

2015

Arch Rheumatol

View full text Add to dashboard Cite

Objectives: This study aims to measure the carotid artery intima-media thickness (IMT) of patients with fibromyalgia (FM) by using ultrasound imaging and to investigate whether carotid IMT measurements were associated with the severity of FM. Patients and methods: Nineteen female patients (mean age 42.9±8.1 years; range 24 to 57 years) and 17 healthy female subjects (mean age 41.5±6.3 years; range 33 to 57 years) were included in this study. The Fibromyalgia Impact Questionnaire was used to determine the severity of FM. After clinical evaluation of the subjects, ultrasound imaging examinations of the carotid IMT were performed. Results: Right and left carotid IMT values were thicker in the patient group in comparison to the control group (p1=0.05, p2=0.03, respectively). Carotid IMT values were correlated with age and body mass index. Carotid IMT values did not have any correlation with blood glucose levels, creatinine levels, serum lipid profile and Fibromyalgia Impact Questionnaire scores in FM patients. Conclusion: Carotid IMT of FM patients seems to be affected. Our finding may have stemmed from endothelial dysfunction possibly due to increased sympathetic activity.

show abstract

“…CIMT is a strong indicator of early atherosclerosis and cardiovascular disease and is commonly used in rheumatological diseases to assess the risk of cardiovascular disease (23,24). In addition, CIMT values are associated with certain clinical parameters (such as lengthy disease duration, degenerations, high inflammatory parameters, and extra-articular symptoms) in diseases, such as rheumatoid arthritis (25). In the literature, studies have shown the presence of early atherosclerosis with increased CIMT values in ankylosing spondylitis, rheumatoid arthritis and Behçet's disease compared to a healthy population (26,27).…”

Section: Discussionmentioning

confidence: 99%

Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Bağcıer¹,

Tufanoğlu²,

Kadıçeşme³

2019

Tod

View full text Add to dashboard Cite

Amaç: Fibromiyaljinin patofizyolojisi henüz tam olarak aydınlatılmamış olmakla birlikte, fibromiyaljili hastalarda enflamasyon ve endotel disfonksiyonunun ortaya çıktığı ileri sürülmüştür. Son yıllarda, endokan enflamasyon ve endotel disfonksiyonu için önemli bir biyobelirteç olarak bildirilmiştir. Erken aterosklerotik vasküler hastalıkları değerlendirmede karotis intima media-kalınlığının (KİMK) değerlendirilmesi önemlidir. Bu çalışmada, fibromiyalji hastalarında serum endokan düzeylerini ve KİMK'yi ölçerek bu mekanizmayı araştırdık, aralarında bir korelasyon olup olmadığını değerlendirdik. Gereç ve Yöntem: İlk kez fibromiyalji tanısı alan 40 kadın hastadan toplanan serum örnekleri ve 40 sağlıklı kadın endokan düzeyleri ve KİMK ultrasonografi ile incelendi ve iki grubun değerleri karşılaştırıldı. Bulgular: Hasta grubunda serum endokan seviyeleri ve KİMK sonuçları kontrol grubuna göre anlamlı olarak yüksek olarak bulunmuştur (p<0,001). Ayrıca FMS'li hastalarda KİMK ile endokan seviyesi arasında çok zayıf bir korelasyon görüldü. Sonuç: Fibromiyaljinin patofizyolojisinde artmış subklinik enflamasyon, endotelyal disfonksiyon ve erken ateroskleroz önemlidir. Artan endokan düzeyi, KİMK ve aralarında korelasyon görülmesi bu mekanizmayı aydınlatmaya katkı sağlar.Objective: Although the pathophysiology of Fibromyalgia syndrome (FMS) has not yet been completely elucidated, it has been suggested that inflammation and endothelial dysfunction occur in patients with FMS. In recent years, endocan has been reported as an important biomarker for inflammation and endothelial dysfunction. It is important to assess carotid intima-media thickness (CIMT) in the evaluation of early atherosclerotic vascular diseases. In this study, we investigated this mechanism by measuring serum endocan levels and CIMT in patients with FMS and evaluated whether there is a correlation between them. Materials and Methods: Serum samples collected from 40 female patients diagnosed with FMS (the patient group) for the first time and 40 healthy female participants' (the control group) endocan levels and CIMT ultrasonography were investigated, and the values of the two groups were compared. Results: Serum endocan levels and CIMT results were significantly higher in the patient group than in the control group (p<0.001). In addition, a very weak correlation was found between CIMT and endocan levels in patients with FMS. Conclusion: Increased subclinical inflammation, endothelial dysfunction, and early atherosclerosis play an important role in the pathophysiology of FMS. Increased endocan levels, CIMT, and the correlation between them will contribute to elucidating this mechanism. Turk J Osteoporos 2019;25:49-52 Abstract

show abstract

The Relationship Between Carotid Intima-Media Thickness and the Activity of Rheumatoid Arthritis

Cited by 32 publications

References 39 publications

Brachial artery flow mediated dilatation and carotid intima media thickness measured by high resolution B-mode ultrasound in patients with rheumatoid arthritis

Brachial artery flow mediated dilatation and carotid intima media thickness measured by high resolution B-mode ultrasound in patients with rheumatoid arthritis

Increased Carotid Intima-Media Thickness in Female Patients With Fibromyalgia: A Preliminary Study

Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Contact Info

Product

Resources

About