2021
DOI: 10.3233/jad-210280
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Abstract: Background: Modifiable vascular risk factors have been associated with late-life cognitive impairment. The Life Simple 7 (LS7) score comprises seven cardiovascular health metrics: smoking, diet, physical activity, body mass index, plasma glucose, total serum cholesterol, and blood pressure. Objective: To investigate the association between individual and composite LS7 metrics and rate of cognitive decline, and potential differences in these associations between young-old and old-old individuals. Methods: This … Show more

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Cited by 17 publications
(25 citation statements)
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References 56 publications
(74 reference statements)
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“…In addition, one of the therapeutic approaches under study is the administration of intranasal insulin [ 118 ]. In addition to diabetes, some cardiovascular events such as stroke, hypertension, hypercholesterolemia, heart failure or atrial fibrillation and other risk factors such as high homocysteine or smoking have been associated with the development of AD [ 119 , 120 , 121 , 122 , 123 , 124 ]. Thus, the design of preventive strategies that allow early diagnosis and treatment of cardiovascular risk factors could contribute significantly to the prevention of AD in the elderly.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, one of the therapeutic approaches under study is the administration of intranasal insulin [ 118 ]. In addition to diabetes, some cardiovascular events such as stroke, hypertension, hypercholesterolemia, heart failure or atrial fibrillation and other risk factors such as high homocysteine or smoking have been associated with the development of AD [ 119 , 120 , 121 , 122 , 123 , 124 ]. Thus, the design of preventive strategies that allow early diagnosis and treatment of cardiovascular risk factors could contribute significantly to the prevention of AD in the elderly.…”
Section: Resultsmentioning
confidence: 99%
“…Prediabetes was defined as having the level of HbA1c between 5.7%–6.5% among participants without diabetes. 7 eTable 1, links.lww.com/WNL/C361 , presents detailed descriptions on the definitions and scores of 7 CVH metrics.…”
Section: Methodsmentioning
confidence: 99%
“…Then, according to tertiles of respective composite CVH metric score among baseline participants in the SNAC-K total sample, we categorized them into unfavorable (lower tertile), intermediate (medium tertile), and favorable (upper tertile) profiles. 7 …”
Section: Methodsmentioning
confidence: 99%
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