The relationship between allergy and chronic rhinosinusitis

Marcus, Sonya; Roland, Lauren T.; DelGaudio, John M.; Wise, Sarah K.

doi:10.1002/lio2.236

Cited by 50 publications

(57 citation statements)

References 39 publications

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“…20,21 Yet, a major limitation in the literature is that all CRSwNP variants were often included within a single "CRSwNP cohort," despite evidence of a greater association of allergy with specific subtypes, including AFRS and CCAD. 9,10 In our analysis, overall allergy prevalence was high (78.7%), as determined by clinical history of AR in CRSwNP patients. However, when separated by subtype, allergy prevalence varied significantly across groups.…”

Section: Discussionmentioning

confidence: 55%

“…However, recent systematic reviews have demonstrated an equivocal relationship between allergy and CRSwNP (aggregate level of evidence D) . Yet, a major limitation in the literature is that all CRSwNP variants were often included within a single “CRSwNP cohort,” despite evidence of a greater association of allergy with specific subtypes, including AFRS and CCAD . In our analysis, overall allergy prevalence was high (78.7%), as determined by clinical history of AR in CRSwNP patients.…”

Section: Discussionmentioning

confidence: 81%

“…Studies have evaluated allergy and asthma prevalence in CRSwNP patients. However, most of those studies included all CRSwNP subtypes within a single “RSwNP cohort,” thus limiting conclusions . This has been particularly true when attempting to elucidate allergy prevalence, which has been estimated to range from 50% to 84% .…”

mentioning

confidence: 99%

“…However, most of those studies included all CRSwNP subtypes within a single "RSwNP cohort," thus limiting conclusions. 9,10 This has been particularly true when attempting to elucidate allergy prevalence, which has been estimated to range from 50% to 84%. [11][12][13] A recent prospective, cohort study reported on asthma prevalence within specific CRSwNP subtypes, but CCAD was not included in the analysis.…”

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confidence: 99%

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Central compartment atopic disease: prevalence of allergy and asthma compared with other subtypes of chronic rhinosinusitis with nasal polyps

Marcus

Schertzer

Roland

et al. 2019

Int Forum Allergy Rhinol

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102

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Background Central compartment atopic disease (CCAD) is a recently described variant of chronic rhinosinusitis with nasal polyp (CRSwNP) associated with inhalant allergy. An association with asthma was noted to be uncommon within our clinical practice. The purpose of this study was to determine allergy and asthma prevalence in CCAD and other CRSwNP subtypes. Methods A retrospective analysis at a tertiary care institution was performed over the period from 2015 to 2019. CRSwNP was grouped into the following subtypes: allergic fungal rhinosinusitis (AFRS); aspirin‐exacerbated respiratory disease (AERD); CCAD; and CRSwNP not otherwise specified (CRSwNP NOS). Patients with sinonasal polyps and concomitant polypoid disease in the central compartment (CRSwNP/CC) were analyzed as a separate cohort for the purpose of this study. Prevalence of allergy and asthma was compared between groups. Results Three hundred fifty‐six patients were included. CRSwNP NOS was the most common subtype (37.1%) and CRSwNP/CC was the least common (3.7%), with other CRS subtypes ranging between 11.5% and 24.2%. Asthma prevalence was highest in AERD (100%) and CRSwNP NOS (37.1%), but substantially lower in AFRS (19.0%) and CCAD (17.1%). Asthma was significantly more common in AERD and CRSwNP NOS when compared with CCAD (p < 0.001 and p = 0.039, respectively). Prevalence of allergy was significantly higher in AFRS (100%), CCAD (97.6%), CRSwNP/CC (84.6%), and AERD (82.6%) when compared with CRSwNP NOS (56.1%) (p < 0.001). Conclusion CCAD represents a clinically distinct phenotype of CRSwNP with a high prevalence of allergy and low prevalence of asthma. Patients with both CCAD and diffuse sinonasal polyps had an allergy prevalence approaching that of CCAD and an asthma prevalence approaching CRSwNP NOS.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Central compartment atopic disease: prevalence of allergy and asthma compared with other subtypes of chronic rhinosinusitis with nasal polyps

Marcus

Schertzer

Roland

et al. 2019

Int Forum Allergy Rhinol

Self Cite

102

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“…The number of rhinosinusogenic orbital and intracranial complications, often leading to disability or death of the patient, has at least not decreased recently [16,17].…”

Section: Resultsmentioning

confidence: 99%

Some Features of Clinical Laboratory and Instrumental Research in Chronic Inflammatory Diseases of the Nose and Paranasal Sinuses in Patients with Myocarditis

2019

IJITEE

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The issues of diagnosis and adequate treatment of rhinosinusitis (RS) remain very relevant today, since this disease is one of the most widespread in the whole world. So, up to 15% of the adult population suffers from various forms of RS; in childrenthis disease is even more common. Otorhinolaryngologists and primary care physicians face RS in their practice on a daily basis. It should be noted that in most European countries and in America, it is the general practitioner who plays the main role in the treatment of uncomplicated forms of the disease. It is important to note that both acute and chronic RS lead to a significant decrease in the quality of life index, comparable with data on cardiological diseases and obstructive pulmonary disease.

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Differential perception and tolerance of chronic rhinosinusitis symptoms as a confounder of gender‐disparate disease burden

Phillips

Bergmark

Hoehle

et al. 2019

Int Forum Allergy Rhinol

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BackgroundPrevious studies have consistently shown that females with chronic rhinosinusitis (CRS) have a greater CRS symptom burden than males with CRS. Our objective was to determine whether differential disease perception could explain this phenomenon.MethodsA total of 500 participants (239 males, 261 females) with CRS were recruited. CRS symptom burden was assessed with the 22‐item Sino‐Nasal Outcome Test (SNOT‐22). General health‐related quality of life was assessed with the visual analog scale of the 5‐dimensional EuroQol questionnaire (EQ‐5D VAS). Participants were asked to rate their CRS symptom control as “Not at all,” “A little,” “Somewhat,” “Very,” and “Completely.” “Not at all,” “A little,” and “Somewhat” controlled symptoms were considered to reflect poorly controlled symptoms.ResultsSNOT‐22 score was significantly more severe (p < 0.001) among females (mean, 44.0; standard deviation [SD], 22.5) than males (mean, 36.3; SD, 20.2). However, there was no significant difference in male‐ vs female‐reported CRS symptom control (p = 0.154). In addition, there was no significant difference (p = 0.109) in EQ‐5D VAS score between males (mean, 70.9; SD, 19.0) and females (mean, 68.4; SD, 19.5). Although a SNOT‐22 score of ≥25 was predictive of poorly controlled symptoms in males (sensitivity, 82.6%; specificity, 62.5%), a SNOT‐22 score of ≥30 was predictive of poorly controlled symptoms in women (sensitivity, 82.4%; specificity, 64.5%).ConclusionFemales with CRS reported more severe SNOT‐22 scores, despite reporting a similar level of symptom control and general health‐related quality of life as men. Women had a higher SNOT‐22 threshold for poorly controlled symptoms. Female CRS patients may have greater perception and tolerance of CRS symptoms without a corresponding significant, disparate downstream impairment.

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The relationship between allergy and chronic rhinosinusitis

Cited by 50 publications

References 39 publications

Central compartment atopic disease: prevalence of allergy and asthma compared with other subtypes of chronic rhinosinusitis with nasal polyps

Central compartment atopic disease: prevalence of allergy and asthma compared with other subtypes of chronic rhinosinusitis with nasal polyps

Some Features of Clinical Laboratory and Instrumental Research in Chronic Inflammatory Diseases of the Nose and Paranasal Sinuses in Patients with Myocarditis

Differential perception and tolerance of chronic rhinosinusitis symptoms as a confounder of gender‐disparate disease burden

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