The Relation of the Structure of Dialkyl Barbituric Acids to the Length of their Action<sup>1</sup>

Shonle, H. A.; Waldo, John H.; Keltch, A. K.; Coles, Harold W.

doi:10.1021/ja01295a013

Cited by 14 publications

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“…C8H1602 requires C, 66.6; , 11.2.) Reduction with lithium aluminum hydride gave 2.2.3trimethylbutan-1 -ol, bp 157 °C (lit.51 bp [55][56][57][58][59][60] °C/15 mm): 0.82 (6 H, s), 0.86 (6 H, d, J = 7 Hz), 1.47 (1 H, s, exchanges with D20), 1.55 (lH,s,; = 7 Hz), 3.47 (2 H, s); bc 17.41 (q), 21.0 (q), 32.6 (d), 37.4 (s), 71.2 (t). 2.2.3.3-Tetramethylbutan-l-ol.…”

Section: Resultsmentioning

confidence: 99%

Conformational analysis and stereodynamics of primary acyclic alkyl radicals by EPR spectroscopy

Ingold¹,

Nonhebel²,

Walton³

1986

J. Phys. Chem.

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Trogler and Manning28 have compiled band positions and molar extinction coefficients for the lowest energy -»• * electronic absorption band of quadruply bonded complexes. These authors point out the deficiencies of an exclusively molecular orbital approach to bonding in these systems. In a weak coupling (small orbital overlap) limit a valence bond description can account for the low intensity of the fully allowed -* * transitions, while configuration interaction can rationalize the "anomalous" redshifting of those -* processes showing increased extinction coefficients for certain classes of dimers. The reader is referred to the original article28 for details. We note in this context that for the functionalized transition-metal dimers it is probably correct to assume that the fourth bond is not a covalent bond between the two atoms, but rather is composed of two "resonating" valence bond structures (antiferromagnetically coupled) with a spin-up electron on one center and a spin-down electron on the other. This situation is similar to H2 when the intemuclear separation is large.

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Section: Resultsmentioning

confidence: 99%

Conformational analysis and stereodynamics of primary acyclic alkyl radicals by EPR spectroscopy

Ingold¹,

Nonhebel²,

Walton³

1986

J. Phys. Chem.

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Antidepressive Action of 5-(1,3-Dimethylbutyl)-5-Ethylbarbituric Acid

Gottlieb¹

1951

Arch NeurPsych

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The Alkylation of Esters and Nitriles

2011

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This chapter is concerned with the reactions of metal salts (enolates) of active methylene compounds with alkylating agents such as alkyl halides to produce allyl derivatives. The first example of this reaction is found in the literature when Geuther prepared ethyl alpha‐ethyl acetoacetate by the reaction of the sodium enolate of ethyl acetoacetate with ethyl iodide. The active methylene compounds considered in the chapter include malonic esters, cyanoacetic esters, malonitriles, monocarboxylic esters and mononitriles. These classes of compounds are characterized by the presence of one or more acidic hydrogen atoms attached to carbon. Only C‐alkylation has been observed with active methylene compounds and are discussed here. Several alternative methods for the preparation of alkyl and aryl derivatives of carboxylic esters and nitriles have been included.

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The Relation of the Structure of Dialkyl Barbituric Acids to the Length of their Action¹

Abstract: Preparation of Some Alkyl Éthyl Éarbíturíc Acids 585 p. p. m.; hence, we have as the difference of density between water made from the hydrogen of benzene and normal water only 0.5 p. p. m. This difference is so small

Cited by 14 publications

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Conformational analysis and stereodynamics of primary acyclic alkyl radicals by EPR spectroscopy

Conformational analysis and stereodynamics of primary acyclic alkyl radicals by EPR spectroscopy

Antidepressive Action of 5-(1,3-Dimethylbutyl)-5-Ethylbarbituric Acid

The Alkylation of Esters and Nitriles

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The Relation of the Structure of Dialkyl Barbituric Acids to the Length of their Action1

Abstract: Preparation of Some Alkyl Éthyl Éarbíturíc Acids 585 p. p. m.; hence, we have as the difference of density between water made from the hydrogen of benzene and normal water only 0.5 p. p. m. This difference is so small

Cited by 14 publications

References 0 publications

Conformational analysis and stereodynamics of primary acyclic alkyl radicals by EPR spectroscopy

Conformational analysis and stereodynamics of primary acyclic alkyl radicals by EPR spectroscopy

Antidepressive Action of 5-(1,3-Dimethylbutyl)-5-Ethylbarbituric Acid

The Alkylation of Esters and Nitriles

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Resources

About

The Relation of the Structure of Dialkyl Barbituric Acids to the Length of their Action¹