The relation of testosterone levels with fatigue and apathy in Parkinson's disease

Kenangil, Gülay; Örken, Dilek Neci̇oğlu; Ur, Emel; Forta, Hulki; Çelik, Muhittin

doi:10.1016/j.clineuro.2008.11.019

Cited by 34 publications

(30 citation statements)

References 29 publications

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“…This was an unexpected finding given that there were no gender differences in significant depressive symptoms among apathetic patients. Although low testosterone levels in elderly men with PD have been associated with symptoms of apathy [31], the role of testosterone in the pathophysiology of apathy in male PD patients is still controversial [18]. Perhaps a better explanation could be that female caregivers are more prone to report negative symptoms, such as apathy, than male caregivers are.…”

Section: Discussionmentioning

confidence: 99%

Apathy in drug-naïve patients with incident Parkinson’s disease: the Norwegian ParkWest study

et al. 2009

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Apathy is a common behavioural problem in Parkinson's disease (PD), with important clinical consequences for patients and their families. However, little is known about apathy in early PD. We examined the frequency and clinical characteristics of apathy in 175 nondemented, drug-naïve patients with newly diagnosed PD and 165 control subjects matched for age, sex and education level in Western and Southern Norway. All participants underwent a comprehensive neurological, psychiatric and neuropsychological evaluation. Apathy was diagnosed based on Neuropsychiatric Inventory assessment and recently proposed consensus criteria. Apathy was found in 22.9% of the PD patients, of whom 37.5% had significant depressive symptoms, whereas none of the control subjects were apathetic. Apathy was significantly associated with male gender, higher depression scores and more severe motor symptoms, but was not associated with greater cognitive impairment. When excluding patients with significant depressive symptoms, apathy remained significantly associated with motor severity. Approximately 50% of the caregivers of patients with apathy reported the apathetic behaviour to be at least moderately distressing. The association between apathy and motor severity in our PD cohort suggests a common underlying pathophysiological mechanism. Future studies should explore the longitudinal effect of dopamine replacement therapy on apathetic behaviour in early PD. The relationship between apathy and male gender needs further study to be fully evaluated.

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Section: Discussionmentioning

confidence: 99%

Apathy in drug-naïve patients with incident Parkinson’s disease: the Norwegian ParkWest study

et al. 2009

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“…It has been shown that testosterone deficiency is common in the older male population and has an increased prevalence in parkinsonian patients (23,24). In another study, testosterone therapy led to significant improvement in the resting tremor and fine motor control in parkinsonian patients with testosterone deficiency (25).…”

Section: Discussionmentioning

confidence: 99%

Castration Induces Parkinson Disease Pathologies in Young Male Mice via Inducible Nitric-oxide Synthase

Khasnavis

Ghosh

Roy

et al. 2013

Journal of Biological Chemistry

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“…Also, concentrations of estradiol and testosterone in the control group were higher than those found in patients. In addition, the level of sex hormones was positively correlated with better mood and quality of life in patients affected with PD; prolactin levels correlated negatively with sex steroid concentrations [78,79]. Therefore, it is extremely necessary to determine the level of hormones that may influence patients' cognition, mood, and quality of life of PD patients.…”

Section: Clinical Aspects In Parkinson Diseasementioning

confidence: 99%

Sex Hormones: Role in Neurodegenerative Diseases and Addiction

Pinto¹,

Castillo²,

RamónSotomayor-Zárate³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

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The brain is a complex organ in charge of regulating the homeostasis of our body and behaviors such as motivation, reward, memory, and movement control, between others. These behaviors are regulated by dopaminergic neurons, which can be modulated by several stimuli throughout the life of an individual. For example, early exposure to sex hormones or endocrine disruptors during critical period of neuronal development affects dopaminergic pathways permanently, producing some disorders such as drug addiction. On the other hand, current knowledge regarding neurodegeneration in Parkinson and Alzheimer diseases pointed out the neuroprotection that estradiol can exert, but contradictory information can also be found in the literature. To know the underlying mechanisms that are related to the above mentioned diseases will help to improve health policies and treatments development.

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The relation of testosterone levels with fatigue and apathy in Parkinson's disease

Cited by 34 publications

References 29 publications

Apathy in drug-naïve patients with incident Parkinson’s disease: the Norwegian ParkWest study

Apathy in drug-naïve patients with incident Parkinson’s disease: the Norwegian ParkWest study

Castration Induces Parkinson Disease Pathologies in Young Male Mice via Inducible Nitric-oxide Synthase

Sex Hormones: Role in Neurodegenerative Diseases and Addiction

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