The relation between splanchnic ischaemia and intestinal damage in necrotising enterocolitis

Schat, Trijntje E.; Heida, Fardou H.; Schurink, Maarten; Laan, Michelle E. van der; Hulzebos, Christian V.; Bos, Arend F.; Kooi, Elisabeth M. W.; Hulscher, Jan B F

doi:10.1136/archdischild-2015-309838

Cited by 29 publications

(37 citation statements)

References 25 publications

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“…In a further study, although NIRS could not distinguish between definite NEC and absence of NEC, it could differentiate between complicated from uncomplicated NEC [21]. Encouragingly, these differences in NIRS readings also correlated well with I-FABP levels, thus validating the use of NIRS to examine intestinal impairment [22].…”

Section: Early Diagnosismentioning

confidence: 94%

Necrotizing enterocolitis symposium: Epidemiology and early diagnosis

Eaton

2017

Journal of Pediatric Surgery

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Section: Early Diagnosismentioning

confidence: 94%

Necrotizing enterocolitis symposium: Epidemiology and early diagnosis

Eaton

2017

Journal of Pediatric Surgery

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“…Transfusion‐associated NEC (‘TA‐NEC’) as a disease entity has been extensively debated, and has recently been implicated in up to 25–30% of all NEC cases (Christensen & Ilstrup, ). The potential pathophysiology of TA‐NEC probably involves multiple mechanisms, including occlusion of the mesenteric capillary bed by adult RBCs (with reduced ability to generate nitric oxide in response to hypoxia), and alteration of mesenteric blood flow, resulting in gut ischaemia/reperfusion injury (Salhany, ; Pitzele et al , ; Schat et al , ). Additionally, significant immunomodulation occurs in infants after transfusion of allogeneic RBCs, leading to increased expression of proinflammatory cytokines [e.g.…”

Section: When Do We Give Rbc Transfusions For Anaemia Of Prematurity?mentioning

confidence: 99%

Management of anaemia in pre‐term infants

Saito-Benz

Flanagan²,

Berry

2019

Br J Haematol

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Pre-term infants have one of the highest transfusion requirements within the hospital-setting. The vast majority of blood transfusions performed in Neonatal Intensive Care Units (NICUs) are for medically stable pre-term infants with anaemia of prematurity, with the aim of improving oxygen delivery to the vital organs during the crucial phase of growth and development. However, despite the frequency of transfusion in this population, the potential benefits and harms of 'top up' transfusion are not fully understood, leading to practice variation between clinicians, institutions and countries. Significant advances have been made in the prevention of anaemia of prematurity, with recent emphasis on optimising infants' circulatory volume at birth via placental transfusion and preserving infants' own blood volume through innovative minimal sampling techniques. More research is urgently needed to establish optimal transfusion thresholds for these high-risk pre-term infants, for whom benefits as well as adverse outcomes may have consequences that extend for decades throughout the recipients' life-course. In this review, we will discuss some of the consensus and controversies regarding optimal management of anaemia in pre-term infants and highlight potential areas for future research.

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“…In a further study, although NIRS could not distinguish between definite NEC and the absence of NEC, it could differentiate between complicated and uncomplicated NEC [31]. Encouragingly, these differences in NIRS readings also correlated well with I-FABP levels, thus validating the use of NIRS to examine intestinal impairment [32]. …”

Section: Improved Diagnostic Methodsmentioning

confidence: 99%

Current Research on the Epidemiology, Pathogenesis, and Management of Necrotizing Enterocolitis

2017

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Despite decades of research on necrotizing enterocolitis, we still do not fully understand the pathogenesis of the disease, or how to prevent or how to treat it. However, as a result of recent significant advances in the microbiology, molecular biology, and cell biology of the intestine of preterm infants and infants with necrotizing enterocolitis, there is some hope that research into this devastating disease will yield some important translation into effective prevention, more rapid diagnosis, and novel therapies.

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The relation between splanchnic ischaemia and intestinal damage in necrotising enterocolitis

Abstract: NTR3239.

Cited by 29 publications

References 25 publications

Necrotizing enterocolitis symposium: Epidemiology and early diagnosis

Necrotizing enterocolitis symposium: Epidemiology and early diagnosis

Management of anaemia in pre‐term infants

Current Research on the Epidemiology, Pathogenesis, and Management of Necrotizing Enterocolitis

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