The Relation Between Class-Specific Serum Rheumatoid Factors and Age in the General Population

Schaardenburg, D. van; Lagaay, A. M.; Otten, Henny G.; Breedveld, Ferdinand C.

doi:10.1093/rheumatology/32.7.546

Cited by 72 publications

(46 citation statements)

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“…In the general (healthy) population, the frequency of RF-positive individuals ranges from 1.3-4% in Caucasians (27,28) to 30% in some tribes of North American Indians (29,30). The frequency of IgM RFs increases with age, whereas IgG RF frequency declines in the elderly (28).…”

Section: Role and Consequence Of Rfs In Infectious Diseasesmentioning

confidence: 99%

Rheumatoid Factors: Host Resistance or Autoimmunity?

Newkirk

2002

Clinical Immunology

116

103

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Section: Role and Consequence Of Rfs In Infectious Diseasesmentioning

confidence: 99%

Rheumatoid Factors: Host Resistance or Autoimmunity?

Newkirk

2002

Clinical Immunology

116

103

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“…They can be detected in 1.3-4.0% of the Caucasian general population and 15-20% of elderly subjects with chronic disease. 12 Immunoassays, irrespective of its nature are susceptible to error from such circulating RFs. 13,14 More care is therefore warranted in the interpretation of all immunoassay results in patients with circulating RF.…”

Section: Rheumatoid Factormentioning

confidence: 99%

Erroneous laboratory results: what clinicians need to know

Ismail

2007

Clinical Medicine

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-Laboratory tests such as 'conventional biochemistry' are analytically robust and trusted, however, some common tests performed by immunoassays, eg thyroid function tests, are inherently more prone to analytical interference, giving rise to incorrect results. Interfering antibodies capable of causing potentially misleading results in immunoassay varied from about 0.4% to 4%. Furthermore, this form of interference cannot be predicted a priori and cannot be detected even by most stringent laboratory quality control assurance schemes because it is unique to an individual sample. Since more than 10 million immunoassay tests are carried out yearly in the UK alone, the impact of this problem on delivering appropriate patient care can no longer be ignored. Clinicians tend to perceive all laboratory data in the same light. Because of this, increased awareness of the inherent limitations of these laboratory tests should trigger a more measured and thoughtful approach, thus ensuring patients receive appropriate investigations and treatment.KEY WORDS: erroneous analytical results, immunoassay, interference, laboratory tests, wrong laboratory results

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“…At the ages of 75 or above approximately 25% of normal individuals are found to be positive for RF [111. This increase is reported to occur mainly in IgM and IgA RF whilst IgG RF levels may decline [16]. Thus, all results need to be suitably cor rected.…”

mentioning

confidence: 99%

“…Hyperimmunisation of experi mental animals, for instance, is often accompanied by the generation of RF [12, 131 and in secondary immune re sponses RF is a frequent occurrence [13,14]. In normal se rum low levels of RF are also demonstrable [15] which arc observed to increase with age [11,16]. It is currently thought that such autoimmune responses are important in development of the normal immune repertoire [17.…”

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confidence: 99%

Rheumatoid Factor: Primary or Secondary Event in the Pathogenesis of RA?

Kalsi

Isenberg²

1993

Int Arch Allergy Immunol

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Rheumatoid factors have been recognised and studied for over fifty years. They are anti-IgG immunoglobulins which occur in most patients with rheumatoid arthritis. Their precise contribution to the pathology of this disease however remains an enigma, since they are also demonstrable in other autoimmune and infectious diseases, as well as in normal healthy controls. Thus the importance of RF in RA may not pertain merely to their presence, but to the nature of the autoantibodies themselves. RF in RA are found to differ from those in control subjects and in other diseases such Waldenstrom’s macroglobulinaemia in terms of their binding affinities for IgG, subclass specificity and V gene usage. The role of RF as either the initiating factor or its occurrence as a secondary event in RA is discussed.

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The Relation Between Class-Specific Serum Rheumatoid Factors and Age in the General Population

Cited by 72 publications

References 0 publications

Rheumatoid Factors: Host Resistance or Autoimmunity?

Rheumatoid Factors: Host Resistance or Autoimmunity?

Erroneous laboratory results: what clinicians need to know

Rheumatoid Factor: Primary or Secondary Event in the Pathogenesis of RA?

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