2016
DOI: 10.1128/microbiolspec.mchd-0020-2015
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Abstract: Eosinophils are a minority circulating granulocyte classically viewed as being involved in host defense against parasites and promoting allergic reactions. However, a series of new regulatory functions for these cells have been identified in the past decade. During homeostasis, eosinophils develop in the bone marrow and migrate from the blood into target tissues following an eotaxin gradient, with IL-5 being a key cytokine for eosinophil proliferation, survival and priming. In multiple target tissues, eosinoph… Show more

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Cited by 144 publications
(70 citation statements)
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References 116 publications
(139 reference statements)
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“…Eosinophils have long been considered as destructive cells associated with type 2 immune responses, including allergic inflammation and helminth infections (Rothenberg and Hogan, 2006). However, accumulating evidence has indicated the multifunctional role of eosinophils as modulators of immune responses (Jung and Rothenberg, 2014;Wen and Rothenberg, 2016). Eosinophils serve as a source of a variety of cytokines, growth factors, and lipid mediators, and express several pattern recognition receptors, including TLRs, nucleotidebinding oligomerization domains, and receptors for advanced glycation end products (Kvarnhammar and Cardell, 2012;Weller and Spencer, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Eosinophils have long been considered as destructive cells associated with type 2 immune responses, including allergic inflammation and helminth infections (Rothenberg and Hogan, 2006). However, accumulating evidence has indicated the multifunctional role of eosinophils as modulators of immune responses (Jung and Rothenberg, 2014;Wen and Rothenberg, 2016). Eosinophils serve as a source of a variety of cytokines, growth factors, and lipid mediators, and express several pattern recognition receptors, including TLRs, nucleotidebinding oligomerization domains, and receptors for advanced glycation end products (Kvarnhammar and Cardell, 2012;Weller and Spencer, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…40 Moreover, human eosinophils play a major role in the modulation of a wide spectrum of innate and adaptive immune cells, including several subsets of lymphocytes, macrophages, mast cells, basophils, neutrophils, dendritic and plasma cells, epithelial and fat cells. 23,41,42 Interleukin-5 (IL-5) is the most important growth, differentiation, and activating factor for human eosinophils. 3,43 This cytokine acts on target cells by binding to the specific IL-5 receptor (IL-5R), which consists of an IL-5 Receptor a (IL-5Ra) subunit and common receptor b subunit (bc).…”
Section: Introductionmentioning
confidence: 99%
“…Eosinophils are bilobed granulocytes originating from the bone marrow from myeloid cells, being released into the bloodstream in a mature manner and at low concentrations (3% of the total of granulocytes). An important characteristic of eosinophils is their high quantity of granules, which have different components, among which are high concentrations of leukotrienes, ROS, IL-4, IL-5, neurotoxins (EDN), main basic protein (MBP), eosinophilic cationic protein (ECP) and eosinophilic peroxidase (EPO) [25,26]. Eosinophils play an important role in hypersensitivity since they are stimulated by IL-5 produced by mast cells and Th2 cells.…”
Section: Eosinophilsmentioning
confidence: 99%