The regulation of PBXs and their emerging role in cancer

Liu, Ying; Ao, Xiang; Zhou, Xuehao; Du, Chengcheng; Kuang, Shouxiang

doi:10.1111/jcmm.17196

Cited by 34 publications

(26 citation statements)

References 132 publications

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“…PBX4 belongs to the PBX family and acts as a transcriptional cofactor of HOX proteins [ 41 , 42 ], playing critical roles in multiple pathophysiological processes, such as organogenesis [ 8 , 9 ], cell differentiation [ 11 , 43 ], embryonic development [ 10 ], and spermatogenesis [ 13 ]. Recent studies have revealed that PBX4 involved cancer pathogenesis and progression [ 44 ]. However, previous research has mainly studied certain types of cancers.…”

Section: Discussionmentioning

confidence: 99%

Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis

Song

2022

Biomolecules

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PBX4 belongs to the pre-B-cell leukemia homeobox (PBX) transcription factors family and acts as a transcriptional cofactor of HOX proteins participating in several pathophysiological processes. Recent studies have revealed that the dysregulation of PBX4 is closely related to multiple diseases, especially cancers. However, the research on PBX4’s potential roles in 33 cancers from the Cancer Genome Atlas (TCGA) is still insufficient. Therefore, we performed a comprehensive pan-cancer analysis to explore the roles of PBX4with multiple public databases. Our results showed that PBX4 was differentially expressed in 17 types of human cancer and significantly correlated to the pathological stage, tumor grade, and immune and molecular subtypes. We used the Kaplan–Meier plotter and PrognoScan databases to find the significant associations between PBX4 expression and prognostic values of multiple cancers. It was also found that PBX4 expression was statistically related to mutation status, DNA methylation, immune infiltration, drug sensitivity, and immune checkpoint blockade (ICB) therapy. Additionally, we found that PBX4 was involved in different functional states of multiple cancers from the single-cell resolution perspective. Enrichment analysis results showed that PBX4-related genes were enriched in the cell cycle process, MAPK cascade, ncRNA metabolic process, positive regulation of GTPase activity, and regulation of lipase activity and mainly participated in the pathways of cholesterol metabolism, base excision repair, herpes simplex virus 1 infection, transcriptional misregulation in cancer, and Epstein–Barr virus infection. Altogether, our integrative analysis could help in better understanding the potential roles of PBX4 in different human cancers.

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Section: Discussionmentioning

confidence: 99%

Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis

Song

2022

Biomolecules

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“…[41,42] They regulate gene expression by directly binding to the 2-8 nucleotides-seed region in 3′UTR of target mRNAs and inhibit their expression or degradation. [43,44] One single miRNA can target hundreds of mRNAs to regulate different pathways. [45] MiRNAs have been shown to be involved in pathological processes of a number of diseases, including cancers, cardiovascular diseases, autoimmune diseases, and KD.…”

Section: Mirnas With Promoting and Inhibiting Roles In Kdmentioning

confidence: 99%

Non‐coding RNAs in Kawasaki disease: Molecular mechanisms and clinical implications

Yang

Ding

et al. 2022

BioEssays

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Kawasaki disease (KD) is an acute self-limiting vasculitis with coronary complications, usually occurring in children. The incidence of KD in children is increasing year by year, mainly in East Asian countries, but relatively stably in Europe and America. Although studies on KD have been reported, the pathogenesis of KD is unknown. With the development of high-throughput sequencing technology, growing number of regulatory noncoding RNAs (ncRNAs) including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) have been identified to involved in KD. However, the role of ncRNAs in KD has not been comprehensively elucidated. Therefore, it is significative to study the regulatory role of ncRNA in KD, which might help to uncover new and effective therapeutic strategies for KD. In this review, we summarize recent studies on ncRNA in KD from the perspectives of immune disorders, inflammatory disorders, and endothelial dysfunction, and highlight the potential of ncRNAs as therapeutic targets for KD.

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“…MiRNAs are a large class of short RNA molecules with 19–24 nucleotides in length, modulating the post-transcriptional silencing of the target gene [ 87 , 88 ]. It has been reported that miRNAs can regulate the expression of many genes involved in functional interaction pathways by targeting their mRNAs [ 89 ].…”

Section: Implications Of Ncrnas In Ad Progressionmentioning

confidence: 99%

Emerging Role of Non-Coding RNAs in Aortic Dissection

Ding

Liu

et al. 2022

Biomolecules

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Aortic dissection (AD) is a fatal cardiovascular acute disease with high incidence and mortality, and it seriously threatens patients’ lives and health. The pathogenesis of AD mainly includes vascular inflammation, extracellular matrix degradation, and phenotypic conversion as well as apoptosis of vascular smooth muscle cells (VSMCs); however, its detailed mechanisms are still not fully elucidated. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are an emerging class of RNA molecules without protein-coding ability, and they play crucial roles in the progression of many diseases, including AD. A growing number of studies have shown that the dysregulation of ncRNAs contributes to the occurrence and development of AD by modulating the expression of specific target genes or the activity of related proteins. In addition, some ncRNAs exhibit great potential as promising biomarkers and therapeutic targets in AD treatment. In this review, we systematically summarize the recent findings on the underlying mechanism of ncRNA involved in AD regulation and highlight their clinical application as biomarkers and therapeutic targets in AD treatment. The information reviewed here will be of great benefit to the development of ncRNA-based therapeutic strategies for AD patients.

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The regulation of PBXs and their emerging role in cancer

Cited by 34 publications

References 132 publications

Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis

Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis

Non‐coding RNAs in Kawasaki disease: Molecular mechanisms and clinical implications

Emerging Role of Non-Coding RNAs in Aortic Dissection

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