2022
DOI: 10.1111/obr.13487
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Abstract: Obesity is associated with changes in the resolution of acute inflammation that contribute to the clinical complications. The exact mechanisms underlying unresolved inflammation in obesity are not fully understood. Adipocyte death leads to pro-inflammatory adipose tissue macrophages, stimulating additional adipocyte apoptosis. Thus, a complex and tightly regulated process to inhibit inflammation and maintain homeostasis after adipocyte apoptosis is needed to maintain health. In normal condition, a specialized … Show more

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Cited by 7 publications
(3 citation statements)
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“…The downregulated genes were involved in the complement cascade, neutrophil degranulation, apoptosis-related network, and IL-18 signaling pathway. The delayed resolution of acute inflammation in obesity due to the deficiency of an effective apoptotic adipocyte removal process can contribute to the underlying inflammatory process, immune system dysfunction, and IR [ 28 ]. M2 macrophages can help efficiently clear these apoptotic cells to reduce the burden of inflammation and long-term complications.…”
Section: Discussionmentioning
confidence: 99%
“…The downregulated genes were involved in the complement cascade, neutrophil degranulation, apoptosis-related network, and IL-18 signaling pathway. The delayed resolution of acute inflammation in obesity due to the deficiency of an effective apoptotic adipocyte removal process can contribute to the underlying inflammatory process, immune system dysfunction, and IR [ 28 ]. M2 macrophages can help efficiently clear these apoptotic cells to reduce the burden of inflammation and long-term complications.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, Salina et al revealed that the engulfment of SARS-CoV-2 infected pro-apoptotic cells by macrophages resulted in the production of inflammatory cytokines and impaired efferocytosis, namely, the failure in phenotype conversion to anti-inflammatory macrophages [33]. Impaired efferocytosis was considered as a major mechanism of metabolic disorders induced by obesity [34] and was observed in ob/ob mice [35]. In this study, we showed that SARS-CoV-2 transcripts were abundant systemically, and expressions of M2 macrophage markers were impaired in ob/ob mice.…”
Section: Discussionmentioning
confidence: 99%
“…Obesity can trigger various defects in organ systems, including in ammatory responses and an imbalance of gut microbial homeostasis, which can also result in cardiovascular disease [3], diabetes [4], stroke [5], and some types of cancer [6]. Maintaining the homeostasis of adipose tissues by regulating the adipocyte number and lipid contents are considered an effective treatment strategy for obesity [7]. In recent years, regulating gut microbiota in obesity has emerged as a potentially effective target for its treatment [8,9].…”
Section: Introductionmentioning
confidence: 99%