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Cited by 800 publications
(473 citation statements)
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References 177 publications
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“…The 5-phosphatase and 3-phosphatase activities of PTPRQ may play complementary roles in inhibiting signaling via PI(3,4,5)P 3 produced by activated PI3-kinase. PI(3,4)P 2 (the product of 5-phosphatase activity) and PI(4,5)P 2 (the product of 3-phosphatase activity) are both less active in activating Akt͞PKB phosphorylation than is PI(3,4,5)P 3 (17). Thus, the 5-phosphatase p150Ship inhibits proliferation stimulated by macrophage colony-stimulating factor (29) and the related inositol 5-phosphatase SHIP2 is a negative regulator of signaling downstream of the insulin receptor (30).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The 5-phosphatase and 3-phosphatase activities of PTPRQ may play complementary roles in inhibiting signaling via PI(3,4,5)P 3 produced by activated PI3-kinase. PI(3,4)P 2 (the product of 5-phosphatase activity) and PI(4,5)P 2 (the product of 3-phosphatase activity) are both less active in activating Akt͞PKB phosphorylation than is PI(3,4,5)P 3 (17). Thus, the 5-phosphatase p150Ship inhibits proliferation stimulated by macrophage colony-stimulating factor (29) and the related inositol 5-phosphatase SHIP2 is a negative regulator of signaling downstream of the insulin receptor (30).…”
Section: Discussionmentioning
confidence: 99%
“…The results above suggested that the sequence of WT PTPRQ adapts it to function as a PIPase rather than as a PTPase. To evaluate the ability of cytoPTPRQ to affect PIP levels in cultured cells, we evaluated the phosphorylation status of the serine͞threonine kinase Akt͞PKB, which is regulated by intracellular levels of PI(3,4,5)P 3 (17). The human glioblastoma cell lines U87MG and U373MG do not express the phosphatidylinositol 3-phosphatase PTEN (18,19), and we did not detect PTPRQ transcripts by RT-PCR (data not shown), or PTPRQ protein, by Western blot analysis with PTPRQ-specific antibody A429 (Fig.…”
Section: Expression Of Cytoptprq In Cultured Cells Reduces Phosphorylmentioning
confidence: 99%
“…Mice deficient in Akt display impeded PPAR␥ expression and adipogenesis (53). Akt and protein kinase A may also phosphorylate CREB (62)(63)(64), whereas ERK contributes to CREB-directed transcription, probably through recruitment of coactivators (54). Dominantnegative CREB inhibits hormone-induced adipocyte differentiation when expressed in preadipocytes, and ectopic expression of constitutively active CREB promotes adipogenesis (65).…”
Section: Galectin-12 In Adipogenesis3bmentioning
confidence: 99%
“…Previous work suggested that rather than inhibit PI3K, the 3-deoxy-PI compounds inhibit the serine/ threonine protein kinase Akt by binding tightly to its PH domain, which normally binds PI(3,4) P 2 or PI (3,4,5), and trapping it in the cytoplasm, thereby preventing phosphorylation by effector kinases. 7 The spectrum of changes in cells caused by these 3-deoxy-PI molecules differs from other widely studied cell growth inhibitors.…”
Section: Introductionmentioning
confidence: 99%