The registry of the international society for heart and lung transplantation: sixteenth official report—1999

Hosenpud, Jeffrey D.; Bennett, Leah E.; Keck, Berkeley M.; Fiol, Bennie; Boucek, Mark M.; Novick, Richard J.

doi:10.1016/s1053-2498(99)00037-6

Cited by 440 publications

(281 citation statements)

References 0 publications

Supporting

Mentioning

237

Contrasting

Unclassified

Order By: Relevance

“…The great majority have been children with CF. The results from the two procedures are similar, and are markedly poorer than for other solid organ transplants, with the International Registry reporting survival of 60±80% at 1 yr and 30±45% at 5 yrs for both procedures [9]. The majority of the early deaths are related to acute rejection or overwhelming infection.…”

Section: Discussionmentioning

confidence: 80%

A model for predicting life expectancy of children with cystic fibrosis

Aurora

Wade²,

Whitmore

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

In this study the authors aimed to produce a model for predicting the life expectancy of children with severe cystic fibrosis (CF) lung disease.The survival of 181 children with severe CF lung disease referred for transplantation assessment 1988±1998 (mean age 11.5 yrs, median survival without transplant 1.9 yrs from date of assessment) were studied. Proportional hazards modelling was used to identify assessment measurements that are of value in predicting longevity.The resultant model included low height predicted forced expiratory volume in one second (FEV1), low minimum oxygen saturation (Sa,O 2 min) during a 12-min walk, high age adjusted resting heart rate, young age, female sex, low plasma albumin, and low blood haemoglobin as predictors for poor prognosis. Extrapolation from the model suggests that a 12-yr old male child with an FEV1 of 30% pred and a Sa,O 2 min of 85% has a 44% risk of death within 2 yrs (95% confidence interval (CI) 35±54%), whilst a female child with the same measurements has a 63% risk of death (95% CI 52±73%) within the same period.The model produced may be of value in predicting the life expectancy of children with severe cystic fibrosis lung disease and in optimizing the timing of lung transplantation.

show abstract

Section: Discussionmentioning

confidence: 80%

A model for predicting life expectancy of children with cystic fibrosis

Aurora

Wade²,

Whitmore

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…Survival following lung or heart-lung transplantation is inferior to that reported for most other solid organ transplant procedures, with the International Society for Heart and Lung Transplantation Registry reporting survival of 70±80% at 1 yr and 30±40% at 5 yrs [16]. The authors centre has previously reported 1 yr survival of 74% and 5 yr survival of 33% for children with CF undergoing lung or heart lung transplantation 1988±1998 [3].…”

Section: Discussionmentioning

confidence: 87%

“…The authors centre has previously reported 1 yr survival of 74% and 5 yr survival of 33% for children with CF undergoing lung or heart lung transplantation 1988±1998 [3]. The majority of early deaths are due to primary graft failure or overwhelming infection, whilst the majority of late deaths are related to bronchiolitis obliterans syndrome (BOS) [16]. Furthermore, there is an increasing awareness of the discrepancy between the number of organs available and the number of potential recipients, with a consequently high attrition rate amongst patients awaiting transplants.…”

Section: Discussionmentioning

confidence: 99%

The effect of prelung transplant clinical status on post-transplant survival of children with cystic fibrosis

Aurora¹,

Gassas²,

Ehtisham³

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

The aim of this study was to determine whether transplanting paediatric cystic fibrosis (CF) patients later in the course of their disease was detrimental to their post‐transplant survival. Data was collected from 51 children with CF undergoing lung or heart‐lung transplantation May 1988–March 1999. The following risk factors were tested by Cox proportional hazards modelling: age at transplant; sex; donor/recipient sex mismatch; donor/recipient cytomegalovirus (CMV) mismatch; cold and warm graft ischaemic times; and donor age. Pretran‐splant forced expiratory volume in one second (FEV1), minimum oxygen saturation obtained during 12 min walk (Sa,O2min), and a survival probability score (SP) calculated from FEV1, age adjusted resting heart rate, age, sex, blood haemoglobin (Hb), and serum albumin were then added to the model. None of the risk factors were significantly correlated with death during the study period. No evidence that clinical status prior to transplant has any effect upon the post‐transplant survival of children with cystic fibrosis was found.

show abstract

“…Although reduced by current immunosuppressive strategies, early graft loss to acute rejection and the subsequent development of chronic rejection remain significant problems in clinical transplantation (1). Transplantation of allogeneic grafts presents several challenges not only to the adaptive but also to the innate immune systems.…”

Section: Introductionmentioning

confidence: 99%

Differential Chemokine and Chemokine Receptor Gene Induction by Ischemia, Alloantigen, and Gene Transfer in Cardiac Grafts

Chen

Ding

Schröppel

et al. 2003

American Journal of Transplantation

View full text Add to dashboard Cite

Transplantation of allogeneic grafts presents several challenges to the innate and adaptive immune systems including chemokine leukocyte recruitment, activation, and effector function. We defined the chemokines and receptors induced by the transplant procedure/ischemia injury, alloantigen and gene transfer vector administration in murine cardiac grafts. E1, E3 deleted AdRSVbgal was transferred into grafts at the time of transplantation, grafts were harvested after 1-14 days, and a pathway-specific cDNA array was used to evaluate the levels of 67 chemokine and chemokine receptor genes. Transplantation resulted in ischemic injury and induction of a number of similar genes in both the syngeneic and allogeneic grafts, such as CXCL1 and CXCL5, which increased dramatically on day 1 and returned rapidly to baseline in the syngeneic grafts. Alloantigen stimulated the adaptive immune response and induced the presence of more inflammatory genes within the grafts, particularly at later time points. The adenovirus vector induced a broader panel of genes, among them potent inflammatory chemokines CXCL9 and CXCL10, that are induced earlier or more strongly compared with alloantigen stimulation alone. As alloantigen and adenovirus vectors both induce similar sets of genes, targeting these molecules may not only inhibit alloimmunity, but also enhance the utility of the gene transfer vector.

show abstract

The registry of the international society for heart and lung transplantation: sixteenth official report—1999

Cited by 440 publications

References 0 publications

A model for predicting life expectancy of children with cystic fibrosis

A model for predicting life expectancy of children with cystic fibrosis

The effect of prelung transplant clinical status on post-transplant survival of children with cystic fibrosis

Differential Chemokine and Chemokine Receptor Gene Induction by Ischemia, Alloantigen, and Gene Transfer in Cardiac Grafts

Contact Info

Product

Resources

About