The Recessive Lu(a‐b‐) Phenotype

Brown, Frances; Simpson, Shirley V.; Cornwall, Sheila; Moore, B. P. L.; Øyen, Ragnhild; Marsh, W. L.

doi:10.1111/j.1423-0410.1974.tb02694.x

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Frequency Of the Lu:l 4 Phenotype1

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1977

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Cited by 22 publications

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“…The phenotypic relationship of Lu8 to the Lutheran system has been established by the finding that Lu(a-b-) red cells are Lu:-8. The re cessive Lu(a-b-) phenotype almost cer tainly arises by homozygous inheritance of a silent Lu allele [2]. Such cells are not known to have any phenotypic aberration outside of the Lutheran blood group and the finding that they are Lu:-8 is strong evidence that Lu8 is a product of the Luther an gene complex.…”

Section: Frequency Of the Lu:l 4 Phenotypementioning

confidence: 71%

Anti-Lul4: A Lutheran Antibody Defining the Product of an Allele at the Lu8 Blood Group Locus

et al. 1977

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A ‘new’ Lutheran-related antibody, named anti-Lu14, reacts with approximately 2.4% of random bloods. Red cells of the rare Lu:-8 phenotype are Lu: 14. The data indicate, with a high probability, that the Lu 14 antigen is a product of an allele of Lu^8 and that Lu^14 and Lus comprise a third pair of alleles at the Lutheran locus. Red cells of the original Sw (a+) propositus are Lu: 14. By coincidence, he has inherited two low-incidence genes. This observation may explain the discrepancy in different families concerning a possible relationship between Sw^a and Lutheran. Pedigree information now suggests that Sw^a is not a Lutheran gene.

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Section: Frequency Of the Lu:l 4 Phenotypementioning

confidence: 71%