The reaction of di-n-butyltin oxide with hexafluoro-2,2-bis(4-carboxyphenyl)propane

Dibutyltin(IV) complexes containing arylazobenzoate ligands: chemistry, in vitro cytotoxic effects on human tumor cell lines and mode of interaction with some enzymes

“…Among the organotin(IV) compounds of formulations (a-c) described above, the triphenyltin compounds 7 and 8 (formulation (c)) possess highest cytotoxicity and are tetrahedral in solution [26]. It is also reported that the four coordinated tin species have a stronger tendency to increase the coordination numbers by O, S or N donor groups, while five-coordinated species do not undergo further coordination and play no long term role in vivo chemistry of organotin(IV) ester [67][68][69][70]. Further, the higher activity of 7 and 8 is attributed to the greater partition coefficient value for triorganotins compared to diorganotins [67,68].…”

Synthesis, crystal structure and in vitro antitumor activity of a novel organotin(IV) complex with 9-hexyl-9H-carbazole-3-carboxylic acid

“…For both the cell lines, the activity of complex I was actually greater than that for 5 fluorouracil as well as the organotin(IV) precursor Ph 3 Sn(OH). It is reasonable that a weak Sn-O bond in complex I is the key factor because the further ligand replacement with biological ligands is possible [17]. The bond Sn(1)-O(2) with the length of 2.563 Å in complex I is much longer than other Sn-O bonds, indicating that the interaction between Sn(1)-O(2) is very weak.…”

Biological aspects of new organotin(IV) compounds of 3-maleimidopropionic acid

“…But this time round diorganotins remarkably proved to be more potent than the triorganotins; which may be to due the complexation of bioactive 3-maleimidopropionic acid [11]. Toxicity also increases due to the attached R group, in the R nÀ1 SnL unit; the L (RCOO) plays an important role after hydrolysis for the transportation of the organotin(IV) moiety to an action site [1][2][3][4]7,27,28].…”