The Radiopharmaceutical Chemistry of Technetium and Rhenium

Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia

“…The aqueous radiochemistry of Group 13 metals has become a matter of paramount importance in the design of new imaging agents anchored onto unusual metallic radioisotopes for PET (gallium-68) or SPECT (indium-111). 1 – 3 To date however, there have been relatively few gallium labelling reactions that do not consist of the well-established NOTA or DOTA core. 4 …”

p-Block metal complexes with bis(pyrazol-1-yl)acetato ligands

“…Isotopes of gallium are a promising alternative to 99m Tc in single photon emission computed tomography (SPECT; 67 Ga) or positron emission tomography (PET; 68 Ga) applications. 29 However, to test the properties, especially in terms of solubility, in vivo stability and bio-distribution, complexes with the stable gallium isotopes 69 Ga/ 71 Ga are usually prepared first. 30 So far, only one gallium complex bearing a μ-O,O-coordinated bdmpza moiety was reported by Uhl et al 18…”

The crystal structure of fac-tricarbonyl(1,10-phenanthroline-κ2 N,N′)-(pyrazole-κN)rhenium(I)nitrate, C18H12O3N4Re

“…The reasons for these are due to the ideal nuclear properties (t 1/2 = 6.02 h; Ec = 140 keV), widespread availability, and low cost for the former and (t 1/2 = 90 h; Emax = 1.07 MeV) and (t 1/2 = 17 h; Emax = 2.12 MeV) for the latter ( 186 Re and 188 Re), respectively. These two radionuclides are working hand in glove with each other for imaging (technetium-99m) and therapy ( 186/188 Re) [10][11][12][13][14].…”