Jukka Puoliväli, Antti Nurmi, Taina-Kaisa Miettinen, Antonio Soleti, Francesca Riccardino, Giedrius Kalesnykas, Taneli Heikkinen, Nina Vartiainen, Raimo Pussinen, Leena Tähtivaara, Kimmo Lehtimäki, Juha Yrjänheikki, Donatella Canistro, Andrea Sapone et al.
Abstract:The purpose of this study was to evaluate the efficacy of the radical scavenger IAC (bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decantionate) in alleviating behavioral deficits and reducing amyloid-β (Aβ) accumulation in an Alzheimer's disease (AD) transgenic Tg2576 mouse model. Daily treatment with IAC (3-30 mg/kg, i.p.) was started at the age of 6 months and continued until the mice were 13 months old. At the age of 9 months and again at 12 months, the mice were tested in open field and water maze test…
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