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Cited by 8 publications
(7 citation statements)
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References 8 publications
(14 reference statements)
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“…Transcription factor Sp1 belongs to the family of Sp/KLF (Kruppel-Like Factor) nuclear proteins [ 20 , 21 ]. Sp1 is responsible for basal transcription of genes, and can also modulate its target gene transcription in response to physiological and pathological stimuli [ 22 ]. It binds with high affinity to GC-rich motifs (such as 5’-GGGGCGGGG-3’ or 5’-G/T-GGGCGG-G/A-C/T-3’ or 5’-G/T-G/A-GGCG-G/T-G/A-G/A-C/T-3’) and regulates the expression of TATA- containing or TATA-less genes via protein-protein, protein-DNA interaction or interplay with other transcription factors, and also through a large number of genes involved in a variety of cellular physiological processes such as growth, apoptosis, differentiation and senescence [ 23 ].…”
Section: Introductionmentioning
confidence: 99%
“…Transcription factor Sp1 belongs to the family of Sp/KLF (Kruppel-Like Factor) nuclear proteins [ 20 , 21 ]. Sp1 is responsible for basal transcription of genes, and can also modulate its target gene transcription in response to physiological and pathological stimuli [ 22 ]. It binds with high affinity to GC-rich motifs (such as 5’-GGGGCGGGG-3’ or 5’-G/T-GGGCGG-G/A-C/T-3’ or 5’-G/T-G/A-GGCG-G/T-G/A-G/A-C/T-3’) and regulates the expression of TATA- containing or TATA-less genes via protein-protein, protein-DNA interaction or interplay with other transcription factors, and also through a large number of genes involved in a variety of cellular physiological processes such as growth, apoptosis, differentiation and senescence [ 23 ].…”
Section: Introductionmentioning
confidence: 99%
“…The complex crosstalk between p53 and Sp1 warrants further study. Intriguingly, p53 and Sp1 share similar consensus sequences at GC-boxes along the human genome, suggesting that they might interplay in transcription regulation and may even compete in binding to specific promoters or function in opposite directions (Oppenheim and Lahav, 2017). It has also been suggested that some of the inhibitory activity of p53 is exerted through downregulation of Sp1 (Jun et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, DOXO treatment reduces KCASH2 protein levels also in MEF p53 −/− (Figure 6B), indicating a p53independent route of action. Indeed, other groups have shown that exposure to DOXO leads to reduced protein levels of Sp1 levels in time-and dose-dependent manners (Oppenheim and Lahav, 2017), which could explain the observed decrease in KCASH2 levels through a decrease in Sp1 levels. Interestingly, we have observed a decrease in Sp1, and consequentially of KCASH2 protein, following DOXO exposition in HEK293T cells (Supplementary Figure 6).…”
Section: Sp1 Negatively Regulates Kcash2 Promoter In P53-deficient Cellsmentioning
confidence: 91%
See 1 more Smart Citation
“…Moreover, Sp1 itself binds ATP7A promoter in human intestinal epithelial cells being fundamental for the HIF2α-mediated induction of gene transcription during iron deficiency/hypoxia to regulate iron balance [86]. Interplay between TAp73 and HIF family proteins [65], Sp1 transcription factor [87,88] or a hierarchical genetic regulation mediated by copper could be therefore involved in this regulatory mechanism. Downstream pathways altered by TAp73 need to be elucidated in the specific context of ATP7A regulation to fully clarify all the participants of this signalling.…”
Section: Discussionmentioning
confidence: 99%