2015
DOI: 10.18632/aging.100855
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Abstract: The phosphatase and tensin homolog gene PTEN is one of the most frequently mutated tumor suppressor genes in human cancer. Loss of PTEN function occurs in a variety of human cancers via its mutation, deletion, transcriptional silencing, or protein instability. PTEN deficiency in cancer has been associated with advanced disease, chemotherapy resistance, and poor survival. Impaired PTEN function, which antagonizes phosphoinositide 3-kinase (PI3K) signaling, causes the accumulation of phosphatidylinositol (3,4,5)… Show more

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Cited by 46 publications
(43 citation statements)
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References 117 publications
(96 reference statements)
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“…32 Moreover, PTEN is known to play a role as a tumor suppressor in many other types of cancer including B cell lymphoma. 33,34 In summary, these studies highlight the importance of metabolic checkpoint regulators in B cell precursors and demonstrate that perturbations in metabolic homeostasis are more detrimental for pre-B cells and their malignant counterparts than other cell types. In the model that emerges from these studies, developing B cells appear to anticipate the possibility of malignant transformation and display increased sensitivity toward metabolic stress to prevent malignant outgrowth.…”
Section: Pre-b Cells Have Been Shown To Lose Viability Upon the Deletmentioning
confidence: 82%
“…32 Moreover, PTEN is known to play a role as a tumor suppressor in many other types of cancer including B cell lymphoma. 33,34 In summary, these studies highlight the importance of metabolic checkpoint regulators in B cell precursors and demonstrate that perturbations in metabolic homeostasis are more detrimental for pre-B cells and their malignant counterparts than other cell types. In the model that emerges from these studies, developing B cells appear to anticipate the possibility of malignant transformation and display increased sensitivity toward metabolic stress to prevent malignant outgrowth.…”
Section: Pre-b Cells Have Been Shown To Lose Viability Upon the Deletmentioning
confidence: 82%
“…While activating mutations in PI3K enzymes are more commonly found in solid malignancies, mutations in PIK3CA , the gene encoding p110α, are found in about 1–8% of DLBCLs [21, 22], and inactivating mutations in PTEN , which negatively regulates the PI3K pathway, are found in 3–22% of DLBCLs [23]. Furthermore, p110α gene amplification [24, 25] and PTEN loss of expression [23] are commonly seen in mantle cell lymphoma (MCL) and diffuse large B cell lymphoma (DLBCL). Preclinical and clinical studies demonstrate that inhibition of PI3K is an effective therapeutic strategy for the treatment of lymphomas.…”
Section: The Pathophysiologic Role Of Pi3k Signaling In Lymphomasmentioning
confidence: 99%
“…116 Loss-of-function of the PTEN protein, resulted from genetic mutation and deletion, abnormal epigenetic regulation, as well as dysregulated protein–protein interactions, may lead to elevated AKT and mTOR activities which promote tumor growth. 117,118 The PTEN-deficient lymphomas mainly include GCB-DLBCL (~11%) and MCL, suggesting the exclusive role of the functional deficiency of PTEN in oncogenesis of these lymphomas. 38,66 …”
Section: Therapeutic Biomarkers Related To Oncogenic Pathways Inmentioning
confidence: 99%