2014
DOI: 10.1038/ncomms3914
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Abstract: Various non-coding regions of the genome, once presumed to be ‘junk’ DNA, have recently been found to be transcriptionally active. In particular, pseudogenes are now known to have important biological roles. Here we report that transcripts of the two tumour suppressor candidate-2 pseudogenes (TUSC2P), found on chromosomes X and Y, are homologous to the 3′-UTR of their corresponding protein coding transcript, TUSC2. TUSC2P and the TUSC2 3′-UTR share many common miRNA-binding sites, including miR-17, miR-93, miR… Show more

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Cited by 91 publications
(76 citation statements)
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“…[31][32][33] Researchers have ascribed this pattern to their high homology to the parental genes. However, other potential mechanisms by which pseudogenes regulate their underlying targets remain unclear.…”
Section: Discussionmentioning
confidence: 99%
“…[31][32][33] Researchers have ascribed this pattern to their high homology to the parental genes. However, other potential mechanisms by which pseudogenes regulate their underlying targets remain unclear.…”
Section: Discussionmentioning
confidence: 99%
“…A luciferase reporter vector (pMir-Report; Ambion) was used to generate the luciferase constructs (Rutnam et al, 2014). A fragment of the 39UTR of mouse Par4 was cloned by RT-PCR, using two primersmusPar4-SacI (59-CCCGAGCTCTAGAAGCTGCACGGGCGGCTTC-39) and musPar4-MluI (59-CCACGCGTTAAATATACAGTCCTCTCA-ACAA-39).…”
Section: Constructsmentioning
confidence: 99%
“…Protein analysis on western blotting was performed as described. 25 RT-PCR and real-time PCR. In total, 2 × 10 6 cells were harvested, and total RNAs were isolated with Qiagen RNeasy mini kit.…”
mentioning
confidence: 99%
“…Tumorigenesis was performed as described previously. 25,27 All animal experiments were conducted according to the guideline approved by the Animal Care Committee at Sunnybrook Research Institute (Protocol Number, AUP 15-076). Animals were kept in the Animal Core Facility of Sunnybrook Research Institute for one week before use.…”
mentioning
confidence: 99%