The pseudogene-derived long non-coding RNA SFTA1P suppresses cell proliferation, migration, and invasion in gastric cancer

Abstract

Pseudogenes were once regarded as transcriptionally inactive and without specific molecular function. However, current evidence shows that pseudogene-derived long non-coding RNAs (lncRNAs) may be crucial regulators of human cancer development, including gastric cancer (GC). In the present study, we report that a pseudogene-derived lncRNA named surfactant associated 1, pseudogene (SFTA1P), which is 693-nt long, was significantly down-regulated in GC tissues compared with that in the adjacent normal tissues. In addition, decreased SFTA1P expression was strongly correlated with advanced tumor lymph node metastasis (TNM) stage, larger tumor size, lymphatic metastasis, and poor prognosis of patients with GC. Moreover, gain-of-function experiments revealed that the overexpression of SFTA1P inhibits cell proliferation, migration, and invasion, thus verifying the tumor inhibitory role of SFTA1P in GC. Furthermore, we investigated the potential action mechanism of SFTA1P. Our results showed that down-regulation of SFTA1P may be associated with decreased TP53 expression. In summary, our work suggests that the pseudogene-derived lncRNA SFTA1P functions as a tumor suppressor in GC and thus may act as a potential diagnostic and therapeutic target of GC.

A Six-LncRNA Expression Signature Associated with Prognosis of Colorectal Cancer Patients

“…In lung cancer, SFTA1P was down-regulated, which could induce upregulation of hnRNP-U-GADD45A followed by promotion of apoptosis and increasing of cisplatin chemosensitivity [34]. Besides, Zhang et al also found that SFTA1P could suppress lung adenocarcinoma cell migration and invasion [35] and similar functions were identified in gastric cancer [36]. That our study provide contradictory results may be due to the types of cancer in study, which warrants further studies to validate the rrole of SFTA1P in CRC.…”

Pseudogene-Derived lncRNAs and Their miRNA Sponging Mechanism in Human Cancer

“…Apart from PTENP1, some pseudogene-derived lncRNAs were also demonstrated to be downregulated in gastric cancer and play tumor suppressive roles in gastric cancer progression. SFTA1P, which is 693 nt long, was obviously decreased in gastric cancer tissues compared with the adjacent normal tissues (Ma H. et al, 2018). Increased expression of SFTA1P suppressed proliferation, migration and invasion of gastric cancer by partially inhibiting p53 signaling.…”

Transcriptomic and functional network features of lung squamous cell carcinoma through integrative analysis of GEO and TCGA data

“…SFTA1P were regarded as a tumor suppressor. Down-regulation of SFTA1P may be associated with decreased TP53 expression 47 . LncRNA SNHG1 promoted non-small cell lung cancer progression 48 .…”