Abstract:The Pre-mRNA processing factor 4B Kinase is a serine/threonine kinase responsible for the phosphorylation of essentials proteins of the tri-snRNP complex in the B Complex of the spliceosome in mammals¹, being that the overexpression of PRP4K has being associated with certain ovary cancer forms ², Paclitaxel and Carboplatin resistance³. The understanding of the kinase domain is crucial for the ligand-based rational drug design, and our research group have being working with the obtainment of high resolution cry… Show more
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