The Protective Role of Testosterone in the Development of Temporomandibular Joint Pain

Fischer, Luana; Clemente, Juliana T.; Tambeli, Cláudia Herrera

doi:10.1016/j.jpain.2006.12.007

Cited by 88 publications

(86 citation statements)

References 31 publications

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“…Reproductive hormones may be the cause for the higher prevalence of pain in females [10]. Conversely, there are indications that male reproductive hormones may have a protective function in association with pain: animal studies have demonstrated that testosterone reduces formalin-induced temporomandibular joint nociception in rats [12]. This antinociceptive effect is probably mediated by the endogenous opioid system [5,11,12].…”

Section: Impact Of Pubertal Development On Tmd Symptomsmentioning

confidence: 99%

“…Es gibt Hinweise dafür, dass die männlichen Sexualhormone eine Schutzfunktion in Bezug auf Schmerzen haben. In Tierversuchen konnte nachgewiesen werden, dass Testosteron formalininduzierten Kiefergelenkschmerz bei Ratten reduzieren kann [12]. Dieser antinozizeptive Effekt wird wahrscheinlich indirekt durch das endogene Opioidsystem bewirkt [5,11,12].…”

Section: Limitationsunclassified

“…In Tierversuchen konnte nachgewiesen werden, dass Testosteron formalininduzierten Kiefergelenkschmerz bei Ratten reduzieren kann [12]. Dieser antinozizeptive Effekt wird wahrscheinlich indirekt durch das endogene Opioidsystem bewirkt [5,11,12]. Dies mag erklären, warum in unserer Studie die Prävalenz selbstberichteter Variablen bei Mädchen zunahm, während sie bei Jungen mit fortschreitender Pubertäts-entwicklung abnahm.…”

Section: Limitationsunclassified

See 2 more Smart Citations

Are temporomandibular disorder symptoms and diagnoses associated with pubertal development in adolescents? An epidemiological study

Hirsch

Hoffmann²,

Türp

2012

J Orofac Orthop

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Section: Impact Of Pubertal Development On Tmd Symptomsmentioning

confidence: 99%

Section: Limitationsunclassified

See 1 more Smart Citation

Are temporomandibular disorder symptoms and diagnoses associated with pubertal development in adolescents? An epidemiological study

Hirsch

Hoffmann²,

Türp

2012

J Orofac Orthop

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“…So far, little is known about the nociceptive effects of the male reproductive hormone testosterone during the menstrual cycle in females, although testosterone has been shown to reduce clinical pain in both men [13] and women [14] . Using the formalin test as a temporomandibular pain disorder model in the rat, Fischer et al [15] demonstrated a significant attenuation of nociception by testosterone at supraphysiological serum levels.…”

mentioning

confidence: 99%

Menstrual Variation in Experimental Pain: Correlation with Gonadal Hormones

et al. 2010

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Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal hormones over the menstrual cycle. Therefore, we assessed the responses to multiple experimental pain stimuli during the menstrual cycle and computed their correlations with the salivary concentrations of the gonadal hormones estrogen and testosterone. Methods: Twenty-four healthy and regularly menstruating women between 20 and 41 years old took part in the study. Detection thresholds (warmth, cold and electrical current) and pain thresholds (cold, heat, pressure and electrical current) were assessed on days 1, 4, 14 and 22 of the menstrual cycle. In each session, salivary samples were collected for the determination of the physiological estrogen 17β-estradiol, progesterone and testosterone. Progesterone was used exclusively to verify regular menstrual cycling. Results: Significant variations in pain thresholds for cold, pressure and electrical stimuli were observed over the menstrual cycle with the highest thresholds on day 22, except for the cold pain thresholds, which peaked on day 14. There were no such changes regarding heat pain and all the detection thresholds. The correlations separately computed for each of the 4 days between salivary estrogen as well as testosterone on the one hand and the detection or pain thresholds on the other hand failed to show significant levels, except for the coupling of testosterone and electrical pain thresholds on day 1. Conclusions: The pain thresholds for all the physical stressors increased after menstruation. The acrophases were located in the follicular (cold pain threshold) or in the luteal phase (pressure and electrical pain thresholds). The results of our correlation analyses indicate only minimal influences of the physiological levels of gonadal hormones on pain sensitivity in women.

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“…r e v i e w s i n p a i n conditions such as TMJ pain 8 . Rheumatoid arthritis patients (both male and female) have been shown to have lower androgen levels than sex-matched controls, and androgen administration improves their symptoms, whilst female workers with lower testosterone levels have more work-related neck and shoulder injuries 9 .…”

Section: Figure 1: Schematic Illustrating How Estradiol and Progestermentioning

confidence: 99%

Hormones and Their Interaction with the Pain Experience

Vincent¹,

Tracey

2008

Reviews in Pain

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The Protective Role of Testosterone in the Development of Temporomandibular Joint Pain

Cited by 88 publications

References 31 publications

Are temporomandibular disorder symptoms and diagnoses associated with pubertal development in adolescents? An epidemiological study

Are temporomandibular disorder symptoms and diagnoses associated with pubertal development in adolescents? An epidemiological study

Menstrual Variation in Experimental Pain: Correlation with Gonadal Hormones

Hormones and Their Interaction with the Pain Experience

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