The Protective Effects of l-Carnitine and Zinc Oxide Nanoparticles Against Diabetic Injury on Sex Steroid Hormones Levels, Oxidative Stress, and Ovarian Histopathological Changes in Rat

Majidi, F. Z.; Rezaei, Nourollah; Zare, Zohreh; Dashti, Ayat; Shafaroudi, Majid Malekzadeh; Abediankenari, Saeed

doi:10.1007/s43032-020-00317-0

Cited by 7 publications

(8 citation statements)

References 38 publications

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“…It also increased serum levels of FSH, LH, estradiol, and progesterone. In women with PCOs, zinc supplementation was able to show a positive effect by increasing the total antioxidant capacity, with a simultaneous decrease in protein carboxyl and malondialdehyde concentrations [ 171 ].…”

Section: A Brief Overview Of the Physiological Roles Of Ros In The Female Reproductive Tractmentioning

confidence: 99%

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

et al. 2021

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Nowadays, infertility is classified as a disease of the reproductive system. Although it does not compromise the life of the individual, it can have detrimental effects on the physiological and psychological health of the couple. Male fertility evaluation is mainly focused on the analysis of sperm parameters. However, the ejaculated fluid is also composed of seminal plasma, and the study of this fluid can provide crucial information to help in the assessment of male fertility status. Total antioxidant capacity of the seminal plasma has been positively correlated with the fertility of men. Moreover, evidence highlights to a similar importance as that of female reproductive tract fluid antioxidant capabilities and female fertility. Herein, we describe the functions of seminal plasma and female reproductive tract fluids, as well as their main antioxidant components and their relationships with fertility outcomes. Additionally, this review contains the most up to date information regarding the mechanisms of the interaction between the male and the female reproductive fluids and the importance of proper antioxidant capacity for fertilization.

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Section: A Brief Overview Of the Physiological Roles Of Ros In The Female Reproductive Tractmentioning

confidence: 99%

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

et al. 2021

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“…Various studies have indicated a wide range of biological effects, including neuroprotective, anti-inflammatory, cardioprotective, and gastroprotective properties (22). It also reported the genoprotective effect of LC via enhancement of the immune response in elderly rats (18,23,24). The therapeutic effect of LC on Alzheimer's, AIDS disease, and ischemic injury has been demonstrated.…”

Section: Introductionmentioning

confidence: 98%

“…As a consequence, it will accumulate fatty acid and results in obesity. Moreover, the LC improves lipid metabolism, increases insulin-like growth factor (IGF), and reduces obesity in rats with a high-fat diet (14,18).…”

Section: Introductionmentioning

confidence: 99%

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Kanani

Etebari

2022

Int J Cancer Manag

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Background: Diabetes is a metabolic disorder characterized by high plasma glucose levels. In this disease, increased production of reactive oxygen species (ROS) results in DNA damage and multiple complications. L-carnitine (LC) has shown a potent antioxidant activity that may reduce oxidative stress. Objectives: This study aims at assaying the effect of LC on DNA damage in streptozotocin-induced diabetic rats and evaluating the changes in antioxidant markers and liver function enzymes after the administration of LC . Methods: In the present study, for induction of diabetes, we injected a single dose of streptozotocin (65 mg/kg) by the intraperitoneal route, and diabetic rats were treated with LC 200, 300, and 400 mg/kg daily for 3 weeks. We detected the DNA damage at 7, 14, and 21 days after induction diabetes by the comet assay method. The blood glucose level, plasma alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were tested. Also, we measured the activity levels of superoxide dismutase (SOD) and intracellular glutathione (GSH). Results: The results of this study demonstrated the increasing amount of DNA damage with the amount and duration of hyperglycemia. L-carnitine treatment significantly decreased the parameters of genotoxicity such as % DNA in the tail, tail length, and tail moment over time. Moreover, the treatment of diabetic rats with LC 300 and 400 mg/kg/day after 21 days led to a remarkable decrease in blood glucose than diabetic rats. Also, we observed that LC can ameliorate enzyme liver function and reduce oxidative stress via enhancement of GSH and SOD levels. Conclusions: The results of this study indicated the protective effect of LC against DNA damage and oxidative stress in diabetic rats.

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“…Several studies have demonstrated that antioxidants can protect tissues against side effects of cyclophosphamide 15–17 . Moreover, some studies have shown that antioxidants such as l‐carnitine and apigenin can protect or improve damaged ovaries after chemotherapy with cyclophosphamide 5,10,18 . Therefore, it seems that other antioxidants may also protect the ovaries against the side effects of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] Moreover, some studies have shown that antioxidants such as l-carnitine and apigenin can protect or improve damaged ovaries after chemotherapy with cyclophosphamide. 5,10,18 Therefore, it seems that other antioxidants may also protect the ovaries against the side effects of chemotherapy. Sesamol (3, 4-methylenedioxyphenol), an effective antioxidant with potential therapeutic benefits, is a ligand of polyphenol isolated from sesame seeds.…”

Section: Introductionmentioning

confidence: 99%

Sesamol protects the function and structure of rat ovaries against side effects of cyclophosphamide by decreasing oxidative stress and apoptosis

Talebi

Hayat

Ghanbari

et al. 2022

J of Obstet and Gynaecol

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Aim: Chemotherapy with cyclophosphamide can damage ovaries and cause infertility in girls and women. Sesamol is a phenolic antioxidant that can protect various organs from damage. The purpose of this study was to evaluate the effects of sesamol on protecting the function and structure of rat ovaries against the side effects of a chemotherapy model with cyclophosphamide. Methods: Twenty-four adult female Wistar rats were randomly divided into three groups: (1) normal group, without any treatment, (2) control group, immediately after receiving cyclophosphamide, 0.5% dimethyl sulfoxide (DMSO) as the solvent of sesamol was intraperitoneally injected for 14 consecutive days, (3) sesamol group, immediately after receiving cyclophosphamide, 50 mg/kg sesamol was intraperitoneally injected for 14 consecutive days. Four weeks after the last injection, superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels in the ovary, anti-Mullerian hormone (AMH) levels in the serum, number of ovarian follicles in different stages, and expression of proteins growth differentiation factor-9 (GDF-9), Bcl-2, and Bax in the ovary were evaluated. Results: The results of SOD activity and MDA levels in the ovary, AMH levels in the serum, number of ovarian follicles in different stages, and expression of proteins GDF9, Bcl-2, and Bax in the ovary were significantly more favorable in the sesamol group than the control group. Conclusions: The results suggest that sesamol may protect function and structure in the rat ovaries against side effects of the chemotherapy model with cyclophosphamide by decreasing oxidative stress and apoptosis in the ovary.

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The Protective Effects of l-Carnitine and Zinc Oxide Nanoparticles Against Diabetic Injury on Sex Steroid Hormones Levels, Oxidative Stress, and Ovarian Histopathological Changes in Rat

Cited by 7 publications

References 38 publications

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

Antioxidants Present in Reproductive Tract Fluids and Their Relevance for Fertility

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Sesamol protects the function and structure of rat ovaries against side effects of cyclophosphamide by decreasing oxidative stress and apoptosis

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