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Cited by 63 publications
(74 citation statements)
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References 41 publications
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“…A favorable microenvironment promotes the biological properties of PDLSCs, which leads to better outcomes of periodontal regeneration (Liu et al, 2018;Zhou et al, 2021). Our results first found that ERM enhance the osteogenic capacity of PDLSCs from inflammatory and aging microenvironments, providing a novel role of ERM and a new thought for optimizing periodontal regeneration.…”
Section: Discussionmentioning
confidence: 52%
“…A favorable microenvironment promotes the biological properties of PDLSCs, which leads to better outcomes of periodontal regeneration (Liu et al, 2018;Zhou et al, 2021). Our results first found that ERM enhance the osteogenic capacity of PDLSCs from inflammatory and aging microenvironments, providing a novel role of ERM and a new thought for optimizing periodontal regeneration.…”
Section: Discussionmentioning
confidence: 52%
“…Besides, FK506 (Tacrolimus) conditionally damages the host immune response, as it displays an excellent effect in blocking the IL‐2 signaling pathway 28 . Unlike those traditional immune suppressors mentioned above, TFNA illustrates a minor influence in metabolism, circulatory system, enzyme catalytic activities and other risks of severe diseases 29‐31 . More importantly, by only eliminating cytokine secretion of T cells, TFNA failed to regulate T cell subsets, such as naïve and memory precursor T cells, which diminished the potential effect for host immunity.…”
Section: Discussionmentioning
confidence: 99%
“… 28 Unlike those traditional immune suppressors mentioned above, TFNA illustrates a minor influence in metabolism, circulatory system, enzyme catalytic activities and other risks of severe diseases. 29 , 30 , 31 More importantly, by only eliminating cytokine secretion of T cells, TFNA failed to regulate T cell subsets, such as naïve and memory precursor T cells, which diminished the potential effect for host immunity. On account of this selective manner in modulating T‐cell immunity, we speculated that the alternative strengths of TFNA in blocking the MAPK signaling pathway at T cells with different statuses may contribute to this phenomenon.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, Zhou. et al applied tFNA to human periodontal ligament stem cells and the data demonstrated its positive effect on proliferation and osteogenic differentiation (Zhou et al, 2021). Ma.…”
Section: Biological Regulatory Ability To Various Cell Typesmentioning
confidence: 99%