The protective effect of small amounts of selenite in sublimate intoxication

Parízek, J; Ošťádalová, I

doi:10.1007/bf02135970

Cited by 435 publications

(131 citation statements)

References 6 publications

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“…4). The first report of the protective effect of selenite against mercury toxicity appeared in 1967 (Parizek & Ostadalova 1967). Since then, numerous studies have shown that selenium supplementation counteracts the toxicity of exposure to mercury.…”

Section: Resultsmentioning

confidence: 99%

Methylmercury, total mercury and total selenium in four common freshwater fish species from Ya-Er Lake, China

Jin

Liang

Jiang

et al. 2006

Environ Geochem Health

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Snakehead fish (Ophiocephalus argus cantor), silver carp (Hypophthalmichthys molitrtix), crucian carp (Carassius carassius), and common carp (Cyprinus carpio) are four common freshwater fish species in China. In this study, the level of methylmercury (MeHg), total mercury (T-Hg), and total selenium (T-Se) in muscle samples of these four fish species from Ya-Er Lake, China, were analyzed using atomic fluorescence spectrometry coupled with high-performance liquid chromatography, and inductively coupled plasma mass spectrometry. The concentrations of MeHg in all the fish species were significantly correlated with those of T-Hg. Higher T-Hg and MeHg concentrations had accumulated in the snakehead fish, which is a strongly predatory fish, than in the other three species. The concentration ratios of MeHg and T-Hg in the muscles of these four fish species were almost equal. Conversely, there was negative correlation between the concentrations of T-Hg and T-Se, which implies that there is a competition between these two elements with respect to bioaccumulation. It is noteworthy that of all the muscle samples tested, the level of T-Hg exceeded the maximum allowable limit in fish [0.4 mg kg )1 (w/w) recommended by the World Health Organization] in 38.46% of those of the silver carp, 18.18% of those of the crucian carp, and 100% of those of snakehead fish. These results show that the consumption of contaminated fish is a potential threat to human health and that necessary preventive measures to safeguard public health should be emphasized.

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Section: Resultsmentioning

confidence: 99%

Methylmercury, total mercury and total selenium in four common freshwater fish species from Ya-Er Lake, China

Jin

Liang

Jiang

et al. 2006

Environ Geochem Health

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“…In contrast, numerous animal studies have reported that Se may decrease MeHg toxicity (Beyrouty and Chan, 2006;Ganther et al, 1972;Parizek and Ostadalova, 1967;Whanger, 1992). These experimental studies provide an understanding in how Se and MeHg may interact under different exposure regimens.…”

Section: Discussionmentioning

confidence: 99%

“…In one of the earliest experiments, Parizek and Ostadalova (1967) showed that Se reduced the acute toxicity of Hg injected into rats, suggesting that Se might complex with Hg in the blood to decrease the availability of each element (Ganther et al, 1972). In another model, quails given MeHg in diet containing tuna survived longer than quails given the same concentration of MeHg in a corn-soya diet, implying Se that was present in the tuna was responsible for this effect (Ganther et al, 1972).…”

Section: Introductionmentioning

confidence: 99%

Selenium as a Potential Protective Factor Against Mercury Developmental Neurotoxicity

Choi¹,

Budtz‐Jørgensen²,

Jorgensen³

et al. 2006

Epidemiology

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Experimental studies suggest that selenium (Se) may decrease methylmercury (MeHg) toxicity under certain exposure regimens. In epidemiological studies, the exposure to MeHg occurs from fish and seafood, which are also a source of beneficial nutrients such as selenium. However, little is known about the potential protective effects of dietary Se against MeHg neurotoxicity in humans. The possible interaction was assessed in two birth cohorts in the Faroe Islands, consisting of singleton term births from 1986 to 1987 (N = 1,022), and 1994 to 1995 (N = 182), respectively. Dietary habits in this fishing population included frequent consumption of seafood, including whale meat high in mercury. Both Hg and Se were measured in cord whole blood. Neurodevelopmental outcomes were evaluated at age 7 years in both cohorts, and the smaller cohort also included neurological assessment on several prior occasions. Each outcome was modeled as a function of Hg and Se interactions (with adjustments for potential risk factors) by expressing the effects of log 10 (Hg) within the lowest 25%, the middle 50%, and the highest 25% of the Se distribution. Surplus Se was present in cord blood, the average being a 10-fold molar excess above MeHg. Regression analyses failed to show consistent effects of Se, or statistically significant interaction terms between Se and MeHg. Overall, no evidence was found that Se was an important protective factor against MeHg neurotoxicity. Prevention, therefore, needs to address MeHg exposures rather than Se intakes. Because of the benefits associated with fish intake during pregnancy, consumers should be advised to maintain a high fish and seafood intake that is low in Hg contamination. Additional research is needed to determine the identity of the nutrients responsible for the beneficial effects.

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“…Several authors showed that selenium (Se) offers protection against Hg toxicity (Parízek and Ostádalová, 1967;Satoh et al, 1985;Ralston, 2009;Lémire et al, 2010) that suggests to take in account Se contents in fishes to assess a real risk associated to Hg intake. Positive relationships has been found between Hg and Se contents in different seawater fishes (Burger and Gochfeld, 2011;Dang and Wang, 2011;Calatayud et al, 2012).…”

Section: Sources Of Hgt and Fish Contamination In Augusta Baymentioning

confidence: 99%

Mercury in fishes from Augusta Bay (southern Italy): Risk assessment and health implication

Manta

Oliveri

et al. 2013

Food and Chemical Toxicology

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a b s t r a c tOur study reports on the total mercury (HgT) concentrations measured in the muscles and livers of several benthic, demersal and pelagic fish species caught inside and outside of Augusta Bay (southern Italy), a semi-enclosed marine area, highly contaminated by the uncontrolled (since the 1950s to 1978s) discharge of the largest European petrochemical plant. Mercury levels in fish tissues are discussed with regard to specific habitat, size and/or age of the specimens and HgT distribution in the bottom sediments. Results suggest a still active Hg release mechanism from the polluted sediments to the marine environment. Also, the high HgT concentrations measured in fishes caught in the external area of the bay imply a potential role of Augusta Bay as a pollutant source for the Mediterranean ecosystem. Finally, values of hazard target quotient (THQ) and estimated weekly intake (EWI) demonstrate that consumption of fishes caught inside the bay represents a serious risk for human health. Also, data indicate that intake of fishes caught from the external area of the bay, especially for that concern demersal and benthic species, could be represent a significant component of risk for the local population.

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The protective effect of small amounts of selenite in sublimate intoxication

Cited by 435 publications

References 6 publications

Methylmercury, total mercury and total selenium in four common freshwater fish species from Ya-Er Lake, China

Methylmercury, total mercury and total selenium in four common freshwater fish species from Ya-Er Lake, China

Selenium as a Potential Protective Factor Against Mercury Developmental Neurotoxicity

Mercury in fishes from Augusta Bay (southern Italy): Risk assessment and health implication

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