The Protective Effect of Moringa Tea Against Cypermethrin-Induced Hepatorenal Dysfunction, Oxidative Stress, and Histopathological Alterations in Female Rats

Abstract

Objectives: Exposure to α-cypermethrin (α-CP) may yield reactive oxygen species (ROS) that is responsible for oxidative stress in mammals. A variety of antioxidants were used to alleviate α-CP-induced toxicity in experimental animals. To the best of our knowledge, there are no attempts of using Moringa oleifera L. (MO) plant extracts against α-CP-induced toxicity. Therefore, this study was conducted.Methods: A total of 16 adult female rats were segregated into equally four groups: One group administered α-CP orally at a dose of 0.05/mg kg bw/ day; and the second group was freely allowed to drink MO leaf extract (moringa tea [MOT]) + the α-CP dose. The other two groups represented negative and positive controls. The daily consumption of the solutions was estimated. At the end of experiments (28 day), all animals were subjected to the planned manifestations.Results: MOT has proved its palatability as drinking solution more than water. Compared with control results, the relative weights of liver and brain recorded significant increases, while that of kidney, heart, spleen, ovary, and lung decreased significantly. Furthermore, alterations in the architecture of the liver, kidney, and brain were observed. α-CP treatment induced high elevation of the levels of aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, creatinine, and malondialdehyde, while caused decline of butyrylcholinesterase, urea, superoxide dismutase, and total antioxidant capacity levels. Coadministration of MOT restored biochemical and histopathological alterations caused by α-CP to a great extent.Conclusion: The present study introduces novel data on the protective effect of MO leaf extract against CP toxicity and sheds light on the palatability of “MOT” to rodents.

Imidacloprid Toxicity and Its Attenuation by Aqueous Extract of Moringa Oleifera Leaf in Zebra Fish, Danio Rerio

“…In the present investigation decreased mortality may be due to boosting up scavenging activity of free radicals by Moringa oleifera. Administration of MLE restored the activities of AST, ALT, ALP, LDH, GGT and total protein toward the normal level induced by pesticides as shown by many workers [26,51,52]. The reversal of increased transaminases by MLE supplement may be due to the healing of hepatic parenchyma and regeneration of hepatocytes.…”

“…Khalil and Korni (2017) have also been reported that Moringa oleifera leaves extract helps in boosting growth, immune system by mitigate oxidative stress in fishes [24]. Previous studies reported the attenuating effect of Moringa leaf extract against pesticides in rats and fishes [25,26].…”

Efek Teh Daun Kelor (Moringa Oleifera Tea) terhadap Kadar Leukosit Ibu Hamil

“…Dalam kondisi seperti ini, beban kerja tubuh menjadi semakin berat yang membuat sistem imun tubuh menurun dan menyebabkan peradangan. Saat terjadi peradangan tubuh akan melawan dengan mengeluarkan zat anti peradangan melalui reaksi oksidasi yang berguna namun menimbulkan dampak buruk yang berbahaya dibanding peradangan itu sendiri (Wang et al, 2017, Mansour et al, 2018.…”

Assessment of methomyl‐induced adrenal gland disruption in rat fetuses and pups: Potential protective effects of propolis supplementation

“…They include many classes of anthropogenic chemicals such as pesticides (Castellani et al, 2021). Methomyl (Lannate1), S‐methyl N‐(methylcarbamoyloxy) thioacetimidate (C5H10N2O2S), is a carbamate insecticide used frequently for controlling insect pests on a set of field crops including fruits, vegetables, grains, and cotton in different parts of the world (Mansour et al, 2018). Methomyl is one of the most commonly used insecticides which was classified as an endocrine disrupter through World Wildlife Fund International in 1997 (Shun‐long et al, 2013).…”